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1.
Nicholas B. Abt Lauren E. Miller Tara E. Mokhtari Derrick T. Lin Jeremy D. Richmon Daniel G. Deschler Mark A. Varvares Sidharth V. Puram 《American journal of otolaryngology》2021,42(6):103070
ObjectiveTo determine prognostic factors and survival patterns for different treatment modalities for nasal cavity (NC) and paranasal sinus (PS) mucosal melanoma (MM).MethodsPatients from 1973 to 2013 were analyzed using the Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier method and multivariable cox proportional hazard modeling were used for survival analyses.ResultsOf 928 cases of mucosal melanoma (NC = 632, PS = 302), increasing age (Hazard Ratio [HR]:1.05/year, p < 0.001), T4 tumors (HR: 1.81, p = 0.02), N1 status (HR: 6.61, p < 0.001), and PS disease (HR: 1.50, p < 0.001) were associated with worse survival. Median survival length was lower for PS versus NC (16 versus 26 months, p < 0.001). Surgery and surgery + radiation therapy (RT) improved survival over non-treatment or RT alone (p < 0.001). Adding RT to surgery did not yield a survival difference compared with surgery alone (p = 0.43). Five-year survival rates for surgery and surgery + RT were similar, at 27.7% and 25.1% (p = 0.43).ConclusionSurgery increased survival significantly over RT alone. RT following surgical resection did not improve survival. 相似文献
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Kara S. Tanaka MD Veronica R. Andaya BA Steven W. Thorpe MD Kenneth R. Gundle MD James B. Hayden MD Yee-Cheen Duong MD Raffi S. Avedian MD David G. Mohler MD Lee J. Morse MD Melissa N. Zimel MD Richard J. O'Donnell MD Andrew Fang MD Robert Lor Randall MD Tina H. Tran BS Christin New BA Rosanna L. Wustrack MD other members of Study Group FORCE 《Journal of surgical oncology》2023,127(1):148-158
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Post-induction hypotension is common and associated with postoperative complications. We hypothesised that pneumatic leg compression reduces post-induction hypotension in elderly patients undergoing robot-assisted laparoscopic prostatectomy. In this double-blind randomised study, patients were allocated randomly to the pneumatic leg compression group (n = 50) or control (n = 50). In the intervention group, pneumatic leg compression was initiated before induction of anaesthesia. In the control group, pneumatic leg compression was initiated 20 min after anaesthesia induction. The primary outcome was the incidence of post-induction hypotension in these groups. Post-induction hypotension was defined as systolic blood pressure < 90 mmHg during the first 20 min after induction. Haemodynamic variables and area under the curve of post-induction systolic blood pressure over time were assessed. Complications associated with pneumatic leg compression were recorded, including: peripheral neuropathy; compartment syndrome; extensive bullae beneath the leg sleeves; and pulmonary thromboembolism. The incidence of post-induction hypotension decreased in the pneumatic leg compression group compared with that in the control group; 5 (10%) vs. 29 (58%), respectively, p < 0.001. In the pneumatic leg compression group, the lowest systolic, diastolic and mean blood pressures 20 min after induction of anaesthesia were significantly greater than the control group. Pneumatic leg compression resulted in an increased area under the curve of systolic blood pressure in the first 20 min after induction, p = 0.001. There were no pneumatic leg compression-related complications. Pneumatic leg compression reduced post-induction hypotension in elderly patients undergoing robot-assisted laparoscopic prostatectomy, suggesting that it is an effective and safe intervention to prevent post-induction hypotension among elderly patients undergoing general anaesthesia. 相似文献
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Sahin Serdar Gundogdu Aycan Nalbantoglu Ufuk Kadioglu Pinar Karaca Zuleyha Hacioglu Aysa Urhan Muhammed Emre Unluhizarci Kursad Demir Ahmet Numan Hora Mehmet Durcan Emre Elbüken Gülsah Dokmetas Hatice Sebile Zuhur Sayid Shafi Kelestimur Fahrettin 《Pituitary》2022,25(3):520-530
Pituitary - Our aim was to investigate the changes in the composition of oral and gut microbiota in patients with newly diagnosed acromegaly and their relationship with IGF-1 levels. Oral and fecal... 相似文献
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<正>克兰费尔特综合征(Klinefelter’s syndrome,KS)简称克氏综合征,属于先天性疾病。由于额外增加至少1条X染色体导致睾丸曲细精管发育异常,KS表现为青春发育不完全和精子生成障碍。迄今为止,对于KS合并中枢性性早熟(central precocious puberty,CPP)或青春早发育快进展,国内外鲜有报道。本文报道1例47,XXY KS合并青春早发育快进展患者,并通过文献复习探讨其可能的发病机制和治疗措施,以提高对该病的认识。 相似文献
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目的 开展养老机构志愿者预立医疗照护计划培训并评价其效果。方法 应用基于Bloom目标教学理论构建的养老机构志愿者预立医疗照护计划培训内容,结合《预立医疗照护计划》知识教育手册、《我的五个愿望》手册、案例视频等教具,通过角色扮演、案例讨论等方式对53名养老机构志愿者进行培训。培训前后使用养老机构志愿者预立医疗照护计划知信行及自我效能问卷对志愿者进行调查,根据志愿者角色扮演表现评价其预立医疗照护计划沟通技能。结果 培训前后志愿者预立医疗照护计划认知、态度、行为意愿及自我效能差异有统计学意义(P<0.05,P<0.01),培训后75.47%志愿者预立医疗照护计划沟通技能达合格及以上水平。结论 预立医疗照护计划培训能改善养老机构志愿者的预立医疗照护计划知信行及自我效能感,培养其预立医疗照护计划沟通能力。 相似文献