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1.
During the period of 1958-1989, 356 patients with pathologically proven primary liver cancer (PLC) were determined by laparotomy to be unresectable. Of the 356 patients, 51 (14.3%) were of subclinical stage, 287 (80.6%) of moderate stage and 18 (5.1%) of late stage. The association of liver cirrhosis was present in 310 patients (87.1%). Treatment modalities in 356 patients were divided into 4 groups: hepatic artery ligation (HAL) (51), hepatic artery infusion (HAI) of chemotherapeutic agents (114), HAL + HAI (117), and HAL + HAI + radiotherapy (74). The 5-year survival rate was zero in the 4 groups in the period of 1958-1977. During 1978-1989, however, the 5-year survival rate was zero in HAL, 7.9% in HAI, 24.4% in HAL + HAI (with second look resection in 10 patients), and 36.5% in HAL + HAI + radiotherapy (with second look resection in 19). The marked improvement in survival in later period was attributable to the accurate site of hepatic artery catheter, longer infusion chemotherapy, and combination treatment, particularly second look resection in some of the patients. These results indicate that HAL + HAI + combination treatment might provide a possible prolongation of survival or even resection in some patients with original unresectable PLC.
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2.
In the study reported here the authors examined the relationships among 40 measures of undergraduate college and medical school performance and competence in 18 medical care tasks during the first year of residency. A rating form was developed for the study to assess residents' competency in the medical care tasks and was sent to the directors of the residency programs entered by the graduates of a medical school. Stepwise multiple regression procedures were used to analyze the relationship between these ratings of residency performance and the residents' premedical and medical school performance and to identify the best predictors of residency performance for the 1982 and 1984 classes. A Rasch model analysis of the residency performance ratings indicated the ease or difficulty of each of the 18 tasks. The results provide information that would allow medical educators to use premedical and medical school performance to predict residents' competencies. The task of "clinically evaluates research and clinical data" was the most difficult for the graduates; that is, they were rated lower on it than on any other task. Two groups of measures of undergraduate and medical school performance were significantly related to performance in the residency: the Part II examination of the National Board of Medical Examiners (particularly the scores on the obstetrics-gynecology, medicine, surgery, and pediatrics subtests and the overall score) and the clerkships (particularly the third-year medicine clerkship, the fourth-year medicine clerkship, and the surgery clerkship).  相似文献
3.
上皮性肿瘤标记物桥粒的提取   总被引:2,自引:1,他引:1  
A simple method is reported for the isolation of desmosomes. The fresh noncornified layers of cow nose epidermis were immersed in 0.1 mol/L citric acid-sodium citrate buffer (pH 2.3, containing 0.5 mmol/L PMSF), and then treated with homogenization and discontinuous sucrose density gradient centrifugation. Desmosomes were located at the 50-56% sucrose interface. Electron microscopy revealed that the characteristic desmosome structure was well preserved, and that a few intermediate filament bundles attached to desmosome plaque were removed by the solubilizing action of the buffer. Approximate 100 mg desmosomes (dry weight) were got from 20g wet noncornified layers of epidermic tissue.  相似文献
4.
为探讨一氧化氮及抗氧化酶在石棉致病中的作用,用改良Myrvik法收集兔肺泡巨噬细胞(AM)进行体外培养,采用硝酸还原酶法测定UICC温石棉处理后兔AM培养液中亚硝酸根(NO^-2)的含量(NO的静态氧化形式),同时利用黄嘌呤及黄嘌呤氧化酶反应系统测定AM的细胞裂解液中SOD的活性,和酶-底物反应形成有色物质来测定AM的细胞裂解液中NOS和GSH-Px的酶活性。  相似文献
5.
31例急性非淋巴细胞白血病细胞DICKE法体外培养的观察   总被引:1,自引:1,他引:0  
Thirty-one patients with acute non-lymphocytic leukemia (ANLL) were studied with Dicke's soft agar marrow culture to identify leukemic colony forming units. Eighteen of them had leukemic colony formation, in those patients, the average survival period was shorter (65d), and none of them achieved remission after chemotherapy. The remaining thirteen patients had no colony formation and had a longer survival period of 119.8 d. In the latter group four out of six who had undergone more than two courses of chemotherapy went into complete remission. Our study showed that patients who had leukemic colony formation had a worse prognosis than those who had no leukemic colony formation.  相似文献
6.
Beta-sitosterol-beta-D-glucoside and its aglycone (the major constituent of the seed oil of Hippophae rhamnoides L.) were investigated for their antigastroulcerative activity in rats. Two experimental gastric ulcer models were selected: chronic acetic acid-induced ulcers and cold stress-induced ulcers. Both the glucoside and its aglycone showed antiulcerative activity in chronic acetic acid-induced gastric ulcer models, and their effects were at least comparable to the effects of wishupin in combination with cimetidine. The effect of aglycone appears better than the glucoside's. Glucoside also showed visibly antiulcerative effects on cold stress-induced ulcers, but wishupin combined with cimetidine did not have such effects.  相似文献
7.
ObjectiveTostudythegenesrelatedtotinminers’lungcancertissueMethodDiferentialdisplaymRNAResultsThirtycDNAfragmentswhichdifer...  相似文献
8.
Three saponins have been isolated from the leaves of Panax japonicus ssp. elegantior var. major (Burkill) Wu et Feng collected in Sichuan, China. They were identified as ginsenoside-Rd (0.5%), ginsenoside-Rg2 (0.025%) and ginsenoside-Rg1 (0.016%), respectively, based on the chemical and spectral analytical data obtained.  相似文献
9.
10.
To study the mechanism of symptomatic postural hypotension in the elderly, we collected 11 such patients to further divide them into group 1 with central nervous system (CNS) involvement and group 2 without CNS involvement. Group 1 was the so-called Shy-Drager syndrome, and group 2 was the elderly postural hypotension not secondary to the medications or other systemic diseases. All patients had various degree of autonomic dysfunction and heterogenous defects in the reflex arc of autonomic nervous system (ANS). Both groups also had normal plasma volume but reduced blood volume. Patients in group 1 had normal level of plasma norepinephrine in recumbent posture, but failed to increase normally after standing (p less than 0.05, as compared the percentage rising with that of the controls). Patients in group 2 had near normal level of plasma norepinephrine in recumbent posture and could rise normally after standing. They also had normal level of plasma epinephrine in recumbent posture, but failed to rise normally after standing (p less than 0.05 as compared with the controls). These findings suggested that impaired responsiveness of end organs as blood vessels and adrenal medulla is one of the major causes responsible for the symptomatic postural hypotension in the elderly without CNS involvement.  相似文献
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