首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   1410篇
  免费   83篇
  国内免费   50篇
耳鼻咽喉   5篇
儿科学   42篇
妇产科学   11篇
基础医学   211篇
口腔科学   10篇
临床医学   125篇
内科学   228篇
皮肤病学   53篇
神经病学   121篇
特种医学   97篇
外科学   131篇
综合类   67篇
预防医学   94篇
眼科学   20篇
药学   162篇
中国医学   6篇
肿瘤学   160篇
  2023年   9篇
  2022年   11篇
  2021年   19篇
  2020年   21篇
  2019年   20篇
  2018年   28篇
  2017年   14篇
  2016年   25篇
  2015年   40篇
  2014年   52篇
  2013年   40篇
  2012年   69篇
  2011年   70篇
  2010年   47篇
  2009年   59篇
  2008年   71篇
  2007年   77篇
  2006年   64篇
  2005年   59篇
  2004年   64篇
  2003年   51篇
  2002年   44篇
  2001年   42篇
  2000年   31篇
  1999年   35篇
  1998年   25篇
  1997年   31篇
  1996年   12篇
  1995年   16篇
  1994年   20篇
  1993年   22篇
  1992年   25篇
  1991年   25篇
  1990年   27篇
  1989年   16篇
  1988年   13篇
  1987年   16篇
  1986年   19篇
  1985年   18篇
  1984年   16篇
  1983年   15篇
  1982年   11篇
  1978年   9篇
  1976年   18篇
  1975年   10篇
  1974年   8篇
  1973年   11篇
  1972年   11篇
  1970年   14篇
  1967年   8篇
排序方式: 共有1543条查询结果,搜索用时 15 毫秒
1.
2.
3.
The Papillon–Lefèvre syndrome (PLS) is a rare, autosomal recessive disease that manifests with palmoplantar keratoderma and destructive periodontitis resulting in early onset periodontal breakdown in deciduous and permanent dentition. Management of this condition is difficult. Here we report one 11‐year‐old consanguineous Muslim boy suffering from PLS. After failing to get any benefit from methotrexate, three cycles of acitretin, each for 2 months, were given 1 month apart. In each cycle, acitretin (25 mg) was given every other day. At the end of the third cycle, treatment was stopped for 4 months to observe the extent of relapse. Thereafter, acitretin (25 mg) was given twice weekly for 4 months and then the patient was followed up for 1 year. Treatment with acitretin resulted in excellent improvement of periodontitis, increase in the alveolar bone height, and periodontal attachment. Improvement remained stable at the end of 1‐year follow‐up. There was excellent (>75%) improvement in keratoderma at the end of active therapy. Mild worsening of palmoplantar keratoderma was noticed whenever the drug was stopped. It improved when the drug was restarted. Other areas remained stable. At the end of 1‐year follow‐up, good improvement (50%) in palmoplantar keratoderma was achieved.  相似文献   
4.

OBJECTIVE

Limited information exists about the influence of urologic complications on health-related quality of life (HRQOL) in patients with type 1 diabetes.

RESEARCH DESIGN AND METHODS

We studied 664 men and 580 women from the Diabetes Control and Complications Trial/Epidemiology of Interventions and Complications Study: mean ages were 51.6 ± 6.6 and 50.6 ± 7.2 years and duration of diabetes was 29.5 ± 4.8 and 29.8 ± 5.1 years, respectively. We assessed associations of sexual dysfunction, lower urinary tract symptoms (LUTS), and, in women, urinary incontinence (UI) with general quality of life (SF-36), perceived value of health (EuroQol-5), diabetes-related quality of life (Diabetes Quality of Life Scale [DQOL]), and psychiatric symptoms (Symptom Checklist 90-R).

RESULTS

In both men and women, urologic complications adversely affected HRQOL and psychiatric symptoms, even after accounting for history of depression leading to treatment. Multivariable analyses accounting for the presence of diabetic retinopathy, neuropathy, and nephropathy also revealed substantial independent effects. In men, for example, the odds (95% CI) of a low DQOL score (≤25th percentile) were 3.01 (1.90–4.75) times greater with erectile dysfunction and 2.65 (1.68–4.18) times greater with LUTS and in women, 2.04 (1.25–3.35) times greater with sexual dysfunction and 2.71 (1.72–4.27) times greater with UI/LUTS combined compared with men and women without such complications. Similar effects were observed for the other measures.

CONCLUSIONS

Sexual dysfunction and urinary complications with type 1 diabetes are associated with decreased quality of life and perceived value of health and with higher levels of psychiatric symptoms, even after accounting for other diabetes complications and depression treatment.  相似文献   
5.
6.
Annals of Surgical Oncology - The role of sentinel lymph node biopsy (SLNB) when ductal carcinoma in situ with microinvasion (DCISM) is identified on core biopsy is unclear. Our aim was to assess...  相似文献   
7.
8.
9.
10.
Bulletin of Environmental Contamination and Toxicology - Halogenated compounds are one of the largest groups of environmental-hazardous chemicals. The removal of the halogen atom from the substrate...  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号