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排序方式: 共有86条查询结果,搜索用时 46 毫秒
1.
Xing-Mei Xie Jian-Ying Zhou Jian Li Ru Li Can Liao Dong-Zhi Li 《Indian journal of hematology & blood transfusion》2015,31(2):242-246
Hemoglobin H disease is the most severe non-fatal form of α-thalassemia syndrome characterized by pronounced microcytic hypochromic hemolytic anemia. It is predominantly seen in Southeast Asia, the Middle East and the Mediterranean. Studies suggest that hemoglobin H disease is not as benign a disorder as previously thought. Newborn screening for hemoglobin H disease is especially appealing because the screening test is based on the detection of hemoglobin Bart’s (γ4) that is only possible within the newborn period. In this study, we reported on a 4-year period of newborn screening program at a mainland Chinese hospital, which detected 35 babies with hemoglobin H disease in a total of 26 152 newborns. The overall prevalence for hemoglobin H disease among all newborns in southern China is ~1 in 1,000. These children need appropriate follow-up and potential comprehensive care during their growth and development. 相似文献
2.
Gu LF Zhang WG Wang FX Cao XM Chen YX He AL Liu J Ma XR 《Journal of cancer research and clinical oncology》2011,137(6):997-1003
Background
To explore the effect of low dose of homoharringtonine (HHT) and cytarabine (Ara-c) combined with granulocyte colony-stimulating factor (G-CSF) priming (HAG regimen) on relapsed or refractory acute myeloid leukemia (AML). 相似文献3.
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Prenatal diagnosis of severe α-thalassemia (α-thal) diseases is usually performed by DNA analysis. To establish a simple and rapid method, we evaluated the reliability of cord blood hemoglobin (Hb) analysis using an automated capillary electrophoresis (CE) system. Our results demonstrated that analysis of fetal Hb using the Sebia CapillaryS 2 is an effective, accurate and simple alternative for prenatal diagnosis of Hb Bart's (γ4) disease. 相似文献
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本研究探讨特发性血小板减少性紫癜(ITP)治疗前后患者外周血中CD4^+CD25^highT细胞(CD25-PE染色阳性〉10^2为CD4^+CD25^highT细胞)的表达情况及其可能的作用机制。应用免疫荧光标记和流式细胞术检测20例治疗前ITP患者、20例治疗后患者及14名正常人外周血中CD4^+CD25^highT细胞的表达。结果表明:ITP患者治疗前外周血T细胞表面CD4^+CD25^highT细胞表达水平明显低于治疗后组及正常对照组(P均〈0.01);ITP治疗后患者组与正常对照组相比无显著性差异(P〉0.05)。结论:ITP治疗前患者外周血中CD4^+CD25^highT细胞水平较正常对照组明显降低,而在治疗有效后有所升高。外周血CD4^+CD25^highT细胞表达率与血小板数量呈正相关。CD4^+CD25^highT细胞水平的检测可作为对ITP患者预后判断的一个有效指标,并可以作为免疫治疗的靶点进行进一步研究。 相似文献
6.
Zhang XM Mao XJ Zhang HL Zheng XY Pham T Adem A Winblad B Mix E Zhu J 《Experimental neurology》2012,233(1):323-332
Apolipoprotein E (apoE) has an intricate biological function in modulating immune responses and apoE isoforms exhibit diverse effects on neurodegenerative and neuroinflammatory disorders. In the present study, we investigated the individual roles of apoE isoforms in the kainic acid (KA)-induced hippocampal neurodegeneration with focus on immune response and microglia functions. ApoE2, 3 and 4 transgenic mice as well as wild-type (WT) mice were treated with KA by intranasal route. ApoE4 overexpressing mice revealed several peculiarities as compared with other transgenic mice and WT mice, i.e. (1) they had more severe KA-induced seizures than apoE2 and 3 mice, (2) they exhibited neuron loss in hippocampus that was higher than in apoE2, 3 and WT mice, (3) KA administration resulted in higher counts of their head drops in the cross-area of elevated plus-maze, (4) they showed lower KA-induced rearing activity than apoE2 mice in the open-field test, (5) their KA-induced microglial expression of MHC-II and CD86 was elevated compared to apoE3 mice, (6) the KA-induced increase of microglial iNOS was higher than that in the other groups of mice, and (7) the TNF-α and IL-6 expression was decreased 7 days after KA application compared to untreated mice and mice treated 1 day with KA. However, the signaling pathway of NFκB or Akt seemed not to be involved in apoE-isoform dependent susceptibility to KA-induced neurotoxicity. In conclusion, over-expression of apoE4 deteriorated KA-induced hippocampal neurodegeneration in C57BL/6 mice, which might result from a higher up-regulation of microglia activation compared to apoE2 and 3 transgenic mice and WT mice. 相似文献
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用抗恶性疟原虫单克隆抗体13A2,制备兔抗血清,经BALB/c-IgG-Sepharose4B和13A2McAb-Sepharose4B柱提纯,得到抗独特型抗体(Ab2)。免疫双扩散试验和ELISA试验表明:抗独特型抗体仅与13A2McAb反应。4i试验显示:当恶性疟原虫抗原浓度为80μg/ml,对13A2Id-Antil3A2Id系统产生81%的抗体结合抑制率,而伯氏疟原虫和诺氏疟原虫抗原检测,抗体结合抑制率分别为27%和2.5%。兔抗血清中抗Ab2抗体(Ab3)滴度为1:640,提示此抗独特型抗体可替代原始抗原诱生抗恶性疟抗体。 相似文献
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