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1.
Population-based sibships with essential hypertension diagnosed before the age of 60 years are being screened in Utah to find two or more hypertensive siblings with the same biochemical abnormality as a clue to an inherited cause for their specific type of hypertension. Among 131 hypertensive subjects in 58 sibships, concordant abnormalities in fasting serum lipid concentrations were observed in two or more siblings in 48% of the sibships. After adjusting for effects of antihypertensive medications, abnormal values reported in only 10% of the Lipid Research Clinics data were observed in 30% of patients for serum triglycerides, 19% for serum low-density lipoprotein cholesterol, and 39% for high-density lipoprotein cholesterol. More than one lipid level was abnormal in almost all concordant sibships, suggesting an association between hypertension and a syndrome of mixed lipid abnormalities, probably familial combined hyperlipidemia (renamed "familial combined dyslipidemia" because of common low high-density lipoprotein cholesterol levels). We conclude that familial dyslipidemic hypertension may be a specific syndrome with lipid abnormalities more severe than blood pressure elevations.  相似文献
2.
硬脑膜动静脉瘘的分型及临床意义   总被引:16,自引:1,他引:15  
Ling F  Wu J  Zhang H 《Zhonghua yi xue za zhi》2001,81(23):1439-1442
目的:探讨硬脑膜动静脉瘘(DAVF)的影像学分类及临床意义。方法:对110例DAVF患者,121个病变按部位进行分区,分别为硬膜窦区,海绵窦区,天幕区,颅底静脉丛区,大脑镰区。按引流静脉分类,Ⅰ型瘘口直接向脑膜静脉或硬脑膜窦引流;Ⅱ型向硬脑膜窦回流后反流入脑或脊髓静脉。Ⅲ型直接向脑或脊髓静脉回流。结果:结合部位和引流静脉对本组病例分类结果为:海绵窦区Ⅰ型38例(69.1%),Ⅱ型17型30.9%,硬膜窦区Ⅰ型11例(33.3%),Ⅱ型16例(56.4%),Ⅲ型2例(10.3%);而天幕区20例,颅底静脉丛6例,大脑镰区1例均为Ⅲ型。结论:相同部位不同引流静脉类型治疗不同,相同引流静脉类型不同部位治疗各异,部位和引流静脉类型联合分类有助分析临床风险和制定治疗方案。  相似文献
3.
Vaginal reconstruction using perineal-thigh flaps with subcutaneous pedicle.   总被引:13,自引:0,他引:13  
A technique of vaginal reconstruction using bilateral, perineal-thigh flaps with subcutaneous pedicle is described. In this procedure, the flaps were raised bilaterally and introduced into an artificial space between the urinary bladder and rectum. The blood supply for the flaps flows from the perineal artery through anastomotic branches to the external pudendal artery. The authors used the technique on four patients, and all the flaps survived entirely. There was no complication. According to a more than two-year follow-up survey, the reconstructed vaginas are expansible and contract little. No stent is needed. There is good sensitivity in the wall of the artificial vagina because sensory nerves run through the flaps.  相似文献
4.
肝癌肝动脉化疗栓塞前后门脉供血的变化   总被引:12,自引:0,他引:12  
用双螺旋CT血管成像技术研究巨块型肝癌肝动脉化疗栓塞前后门脉对肿瘤血供的变化及门脉供血对化疗栓塞(TACE)治疗的影响。结果显示,门脉对巨块型肝癌的供血主要位于肿块周边部,经TACE治疗后肿块周边部门脉血供增加(P〈0.05),且与肿块缩小程度呈负相关(r=0.79,P〈0.01)。提示门脉对肿块供血明显者有必要行门脉途径介入治疗。  相似文献
5.
螺旋CT三维成像对颌面部骨折的诊断价值   总被引:6,自引:0,他引:6  
目的 探讨螺旋CT三维成像对于颌央部骨折的诊断价值。方法不对25例颌面部外伤患者进行螺旋CT薄层扫描和三维重建成像。结果 螺旋CT三维成像能够立体地显示骨折的位置、形态、范围和类型。结论 螺旋CT三维成像对于显示颌面部骨折的空间关系。具有重要的诊断价值。  相似文献
6.
活动期与静止期牙周炎患牙龈沟液中IL—6的含量   总被引:6,自引:0,他引:6  
OBJECTIVE: To reveal the relationship between IL-6 and the activity of periodontitis. METHODS: The concentration of IL-6 in gingival crevicular fluid (GCF) was measure by ELISA. Sixty teeth from 39 patients with adult periodontitis were sampled, among which there were 29 teeth in active phase, while the rest were in non-active phase. RESULTS: Significant difference was found in the level of IL-6 in GCF between the active group (10.65 +/- 22.05 ng/ml) and the non-active group (1.73 +/- 0.53 ng/ml, P < 0.05). CONCLUSION: The level of IL-6 in GCF may be a useful indicator of the activity of periodontitis.  相似文献
7.
目的 探索戊型肝炎病毒(HEV)敏感细胞及体外培养条件。为HEV体外研究提供基础。方法 用戊肝患者急性期阳性粪便悬液感染恒河猴进行毒种的扩增与活化。超速离心处理猴阳性粪便标本获取培养用毒种,将其接种于各种人源性细胞(包括人胚肺二倍体细胞KMB17、人肺癌细胞A549、人肝癌细胞BEL7402、人宫颈癌细胞Hela)和非人灵长类细胞(非洲绿猴肾细胞Vero)。通过细胞病变观察,RT-PCR检测及免疫荧光实验来判定细胞是否对HEV敏感。结果 KMB17、A549、BEL7402细胞中第一代传代7-9d出现细胞病变,11-13d脱落,传至10代仍可经正链和负链RT-PCR检测到HEV基因组正链RNA和复制的负链RNA的存在,而Hela,Vero细胞未见细胞病变,分别于2-4代后经RT-PCR不能扩增到特异片段。在KMB17细胞培养体系中经免疫荧光实验表明实验组有明显荧光着色,病毒捕获RT-PCR扩增到特异片段。结论 在采用的培养条件下,KMB17、A549、BEL7402细胞对HEV敏感,而Hela、Vero细胞不敏感。本研究建立了一定代次内HEV组织培养体系。  相似文献
8.
To quantitatively assess risk for lung cancer of metal miners,a historical cohort study was conducted.The cohort consisted of 1113 miners who were employed to underground work for at least 12 months between January 1,1960and December,12,1974,According to the records or dust concentration,a cumulative dust dose of each miner in the cohort was estimated.There wer 162 deaths in total and 45 deaths from lung cancer with a SMR of 2184,The SMR for lung cancer increased from 1019 for those with cumulative dust of less than 500mg-year to 2469 for those with the dose of greater than 4500mg-year.Furthermore,the risk in the highest category of combined cumulative dust dose and cigarette smoking was 46-fold greater than the lowest category of dust dose and smoking.This study showed that there was an exposure-response relationship between metal ore dust and lung cancer,and an interaction of lung cancer between smoking and metal ore dust exposure.  相似文献
9.
X Zhang  Y Li  D Wu  J Wu  Q Cheng  X Zeng  X Liu 《华西医科大学学报》2001,32(4):569-571
OBJECTIVE: To investigate the post-traumatic changes in the serum level of tumor specific growth factor (TSGF) and their relationship with Injury Severity Score and to inquire into the possible mechanism and clinical significance. METHODS: Fifty patients with mechanical trauma were eligible and included. According to the standard of Injury Severity Score (ISS), the patients were divided into there groups: mild degree group, (ISS < or = 16, n = 31) severe degree group (16 < ISS < 25, n = 13) extreme severe degree group (ISS > or = 25, n = 6). The blood samples of all patients were obtained within 24 hours, and those of 25 dynamically observed patients were obtained on days 3, 5, 7, 9 and 12. RESULTS: The serum level of TSGF was significantly higher in patients with trauma in different groups (P < 0.05). The dynamical observation showed that the index demonstrated curve changes with increase in early stage and decrease later. the climax of TSGF appeared on 7 day in all 3 groups. The TSGF serum levels in extremely severe degree and severe degree groups > mild degree group on days 5, 7, 9 and 12 day (P < 0.05). CONCLUSION: TSGF has relationship with the inflammatory response and recovery of trauma.  相似文献
10.
人类巨细胞病地人胚肺细胞HOX基因表达的影响   总被引:3,自引:1,他引:2  
应用半定量RT-PCR技术研究人胚肺(HEL)细胞HOX基因的表达状态及人类巨细胞病毒(HCMV)对HEL细胞HOX基因表达的影响。结果发现:HEL细胞表达HOXB7基因;HCMV感染后,其表达上调;用全反式维甲酸(ATRA)处理HEL细胞,HCMV对HOXB7基因表达的上调作用更强。提示HCMV可能通过影响HOXB7基因的表达导致胚胎发育畸形。  相似文献
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