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COGNITIVE AND EMOTIONAL IMPAIRMENT IN OBSTRUCTIVE SLEEP APNEA SYNDROME   总被引:9,自引:0,他引:9  
Objective To evaluate the emotional and cognitive status in patients with obstructive sleep apnea syndrome (OSAS),using neuropsychological tests and evoked-related potential (P3).Methods Sixteen patients diagnosed of OSAS were tested by Hamilton rating scale for anxiety (HRSA) and Hamilton rating scale for depression (HRSD). Other three groups, OSAS patient group (n = 21), snoring group (n = 21), and control group (n = 21), were administered polysomnography (PSG), auditory evoked event-related potential (P3), and clinic memory test. The results were analyzed using general linear model (GLM) analysis and Post Hoc test.Results Twelve OSAS patients' scores of HRSA and HRSD were beyond the normal range, 26.42 ± 4.48 and 22.08 ±3.97 respectively. The auditory P3 latency in OSAS group was 363.1 ± 22.9 ms (Fz), 368.57 ± 28.03 ms (Cz), in snoring group 336.57 ± 31.08 ms (Fz), 339.81 ± 31.76 ms (Cz), in control group 340.8 ± 28.7 ms (Fz), 338.29 ± 29.21 ms (Cz).There were significant differences between OSAS group and snoring group, as well as control group (P < 0.05). No significant difference was seen between snoring group and control group. No significant difference was noted in P3 amplitude among three groups. Memory quotient (MQ) reduced in snoring group compared with control group.Conclusions Emotional disturbances are common clinical features in OSAS patients. Abnormal auditory P3 latency indicates the cognitive dysfunction in OSAS patients. Nocturnal hypoxaemia may play an important role on it. Snorers should be monitored because of the tendency to develop cognitive impairment.  相似文献
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[目的]探讨肿瘤坏死因子-α(TNF-α)诱导大鼠近端肾小管上皮细胞株NRK-52E上调表达趋化因子fractalkine的时间和剂量效应,并观察肾小管上皮细胞fractalkine表达是否介导了对巨噬细胞的趋化作用.[方法]应用免疫荧光细胞化学技术、逆转录-聚合酶链反应(RT-PCR)及Western印迹法检测TNF-α诱导的NRK-52E fractalkine表达,应用Transwell装置观察NRK-52E对大鼠巨噬细胞株RAW 264.7的趋化效应,以及fractalkine中和抗体对趋化效应的影响.[结果]正常培养的NRK-52E可表达少量的fractalkine,TNF-α(40 ng/mL)刺激后1 h,fractalkine的mRNA和蛋白表达增加尚不明显,在刺激后6 h表达即明显增加,持续至24~48 h.10 ng/mL TNF-α即可诱导fractalkine mRNA和蛋白表达增加,20 ng/mL及40 ng/mL TNF-α诱导fractalkine表达增加的效应更加明显.NRK-52E fractalkine表达上调可明显增强其趋化巨噬细胞的效应,而fractalkine中和抗体可明显抑制此种趋化效应.[结论]TNF-α能够以时间和剂量依赖方式上调肾小管上皮细胞fractalkine的mRNA和蛋白表达,且fractalkine在介导肾小管上皮细胞对巨噬细胞的趋化作用中起重要作用.  相似文献
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MHYAoitwhSTe GvHerarEv,Ne oIs Anldy igs9reaavpsieast i(eoGnrtDs m)wy iiosthp na iotnhtty ruanc acrsaosnmoicamilao tanerd.-ery occlusive lesions(IAOLs)associated with GD werereported in the previous literatures.1-6We presumed thatthere are some relationships between them,and at the sametime these vascular stenoses must be treated promptly,oth-erwise irreversible stroke will happen.So in current study,we investigated the clinical manifestations and the distribu-tion characteristics of IA…  相似文献
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OBJECTIVE: To investigate the distribution and clinical manifestations of intracranial arterial occlusive lesions (IAOLs), and their correlation with thyroid function. METHODS: We enrolled 7 patients who had Graves' disease (GD) with IAOLs screened and evidenced by transcranial Doppler, then further confirmed with digital substract angiography in 2 patients and magnetic resonance angiography in 5 patients. Brain magnetic resonance imaging (MRI) was performed in all 7 patients. Three patients were followed up. RESULTS: Among 7 patients, 1 was male and 6 were females. The mean age was 32.0 +/- 5.5 (range from 11 to 49) years old. Six of them had symptoms of GD but one was asymptomatic with abnormality of T3, T4, and thyroid stimulating hormone. The lesions of intracranial arteries were symmetrical bilaterally in the internal carotid artery system in 6 patients, as well as asymmetrical in 1 patient Terminal internal carotid artery (TICA) were involved in all 7 patients. Middle cerebral artery (MCA) were involved in 3, anterior cerebral artery in 2, and basilar artery in 1 patient. Net-like collateral vessels and mimic moyamoya disease were observed in the vicinity of the occlusive arteries in 2 patients. All patients presented symptoms of ischemic stroke including transient ischemic attack and/or infarction while IAOLs were found. Three patients had obvious involuntary movements. Brain MRI revealed infarctions located in the cortex, basal ganglion, or hemiovular center in 5 patients. The remaining 2 patients had normal brain MRI. The neurological symptoms were improved concomitant with relief of the thyroid function in 2 patients, while IAOLs were aggravated with deterioration of the thyroid function in 1 patient. CONCLUSION: IAOLs in patients with GD mainly involve intracranial arteries, especially the TICA and MCA, which is similar to moyamoya disease. The neurological symptoms and severity of involved arteries may relieve while the hyperthyroidism is gradually under control.  相似文献
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目的:寻找新的人Flt3配体(hFL)的差异剪接体.方法:从健康志愿者外周血中分离单个核细胞,一步法提取总RNA,逆转录成cDNA,应用胞外区特异性引物PCR扩增hFL的胞外区并克隆至真核表达质粒,进行序列测定分析.结果:序列分析发现了两个新的hFL的差异剪接体,均发生在重要的第5外显子功能域,分别在434 bp处有一个胞嘧啶的插入和在426~478 bp之间缺失了53个bp.结论:hFL存在两个新的差异剪接体,此项发现为进一步的功能研究提供了基础.  相似文献
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