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1.
Renata Albuquerque COSTA Rayza Lima ARAúJO Regine Helena Silva dos Fernandes VIEIRA 《Revista do Instituto de Medicina Tropical de S?o Paulo》2015,57(3):193-196
The following study aimed to determine the antimicrobial susceptibility profile of
Vibrio parahaemolyticus strains from fresh and frozen oysters
Crassostrea rhizophorae sold in Fortaleza-Brazil. An antibiogram
was performed on 87 isolates using nine antibiotics: gentamicin (Gen 10 µg),
ampicillin (Amp 10 µg), penicillin G (Pen 10U), ciprofloxacin (Cip 5 µg),
chloramphenicol (Chl 30 µg), nalidixic acid (Nal 30 µg), tetracycline (Tet 30 µg),
vancomycin (Van 30 µg) and erythromycin (Ery 15 µg). All strains were resistant to at
least one antibiotic, and 85 (97.7%) were multi-resistant, with predominance of the
Van+ Pen+Amp resistance profile (n = 46). Plasmid resistance to Pen, Amp and Ery was
detected. Thus, the risk that raw oyster consumption poses to the health of consumers
is highlighted, due to the fact that these bivalves may host antibacterial-resistant
microorganisms. 相似文献
2.
3.
NATÁLIA ANTÓNIO M.D. ANA SOARES M.D. TIAGO CARVALHEIRO M.D. ROSA FERNANDES Ph.D. ARTUR PAIVA Ph.D. MIGUEL VENTURA M.D. JOÃO CRISTÓVÃO M.D. LUÍS ELVAS M.D. LINO GONÇALVES Ph.D. LUÍS A. PROVIDÊNCIA Ph.D. CARLOS FONTES RIBEIRO Ph.D. GUILHERME MARIANO PEGO M.D. 《Pacing and clinical electrophysiology : PACE》2014,37(6):731-739
4.
5.
Stephanie H. Guseh J. Alejandro Rauh-HainRosemary H. Tambouret Michelle DavisRachel M. Clark David M. BorutaAnnekathryn Goodman Whitfield B. GrowdonJohn O. Schorge Marcela G. del Carmen 《Gynecologic oncology》2014
Objectives
The aim of this study is to compare response to chemotherapy and survival between patients with transitional call carcinoma of the ovary (TCCO) and papillary serous ovarian cancer (PSOC).Methods
We identified women with both pure and mixed TCCO who were treated between 2000 and 2010. Each case was matched to two women with PSOC by age, grade, stage, and year of diagnosis. Correlation between categorical variables was assessed with chi square test. The Kaplan–Meier survival analysis was used to generate overall survival data (OS). Factors predictive of outcome were compared using the log-rank test and Cox proportional hazards model.Results
Eighty-one women diagnosed with TCCO were selected as cases and compared to 162 controls. Women with TCCO had a lower rate of platinum resistance compared to controls (9% vs. 25%; p = 0.01). When multivariate logistic regression was used to control for other factors independently associated with platinum resistance, patients with TCCO had a significantly lower risk of platinum resistance compared to PSOC. Median progression-free survival was not significantly different (27 months vs. 22 months; p = 0.15) for women with TCCO and PSOC, respectively. Median OS, however, was significantly different at 83 months vs. 52 months for the TCCO and PSOC groups, respectively (p = 0.01). A Cox proportional hazards model identified optimal cytoreduction, transitional cell histology, age, stage, and platinum and paclitaxel chemotherapy as independent predictors of OS.Conclusions
Patients with TCCO are less likely to demonstrate resistance to platinum chemotherapy and have improved overall survival when compared to patients with PSOC. 相似文献6.
Fabricio Ferreira COELHO Marcos Vinícius PERINI Jaime Arthur Pirola KRUGER Gilton Marques FONSECA Raphael Leonardo Cunha de ARAúJO Fábio Ferrari MAKDISSI Renato Micelli LUPINACCI Paulo HERMAN 《Brazilian archives of digestive surgery》2014,27(2):138-144
Introduction
The treatment of portal hypertension is complex and the the best strategy depends on the underlying disease (cirrhosis vs. schistosomiasis), patient''s clinical condition and time on it is performed (during an acute episode of variceal bleeding or electively, as pre-primary, primary or secondary prophylaxis). With the advent of new pharmacological options and technical development of endoscopy and interventional radiology treatment of portal hypertension has changed in recent decades.Aim
To review the strategies employed in elective and emergency treatment of variceal bleeding in cirrhotic and schistosomotic patients.Methods
Survey of publications in PubMed, Embase, Lilacs, SciELO and Cochrane databases through June 2013, using the headings: portal hypertension, esophageal and gastric varices, variceal bleeding, liver cirrhosis, schistosomiasis mansoni, surgical treatment, pharmacological treatment, secondary prophylaxis, primary prophylaxis, pre-primary prophylaxis.Conclusion
Pre-primary prophylaxis doesn''t have specific treatment strategies; the best recommendation is treatment of the underlying disease. Primary prophylaxis should be performed in cirrhotic patients with beta-blockers or endoscopic variceal ligation. There is controversy regarding the effectiveness of primary prophylaxis in patients with schistosomiasis; when indicated, it is done with beta-blockers or endoscopic therapy in high-risk varices. Treatment of acute variceal bleeding is systematized in the literature, combination of vasoconstrictor drugs and endoscopic therapy, provided significant decline in mortality over the last decades. TIPS and surgical treatment are options as rescue therapy. Secondary prophylaxis plays a fundamental role in the reduction of recurrent bleeding, the best option in cirrhotic patients is the combination of pharmacological therapy with beta-blockers and endoscopic band ligation. TIPS or surgical treatment, are options for controlling rebleeding on failure of secondary prophylaxis. Despite the increasing evidence of the effectiveness of pharmacological and endoscopic treatment in schistosomotic patients, surgical therapy still plays an important role in secondary prophylaxis. 相似文献7.
J. Alejandro Rauh-Hain Elisabeth J. DiverJoel T. Clemmer Leslie S. BradfordRachel M. Clark Whitfield B. GrowdonA.K. Goodman David M. Boruta IIJohn O. Schorge Marcela G. del Carmen 《Gynecologic oncology》2013
Objective
The aims of this study are to determine if outcomes of patients with ovarian carcinosarcoma (OCS) differ from women with high grade papillary serous ovarian carcinoma when compared by stage as well as to identify any associated clinico-pathologic factors.Methods
The Surveillance, Epidemiology, and End Results (SEER) Program data for all 18 registries from 1998 to 2009 was reviewed to identify women with OCS and high grade papillary serous carcinoma of the ovary. Demographic and clinical data were compared, and the impact of tumor histology on survival was analyzed using the Kaplan–Meier method. Factors predictive of outcome were compared using the Cox proportional hazard model.Results
The final study group consisted of 14,753 women. 1334 (9.04%) had OCS and 13,419 (90.96%) had high grade papillary serous carcinoma of the ovary. Overall, women with OCS had a worse five-year, disease specific survival rate, 28.2% vs. 38.4% (P < 0.001). This difference persisted for each FIGO disease stages I–IV, with five year survival consistently worse for women with OCS compared with papillary serous carcinoma. Over the entire study period, after adjusting for histology, age, period of diagnosis, SEER registry, marital status, stage, surgery, radiotherapy, lymph node dissection, and history of secondary malignancy after the diagnosis of ovarian cancer, carcinosarcoma histology was associated with decreased cancer-specific survival.Conclusions
OCS is associated with a poor prognosis compared to high grade papillary serous carcinoma of the ovary. This difference was noted across all FIGO stages. 相似文献8.
9.
Eline Schreuders Jerome Sint Nicolaas Vincent de Jonge Harmke van Kooten Isaac Soo Daniel Sadowski Clarence Wong Monique E van Leerdam Ernst J Kuipers Sander JO Veldhuyzen van Zanten 《Journal canadien de gastroenterologie》2013,27(1):33-38
BACKGROUND:
Adherence to surveillance colonoscopy guidelines is important to prevent colorectal cancer (CRC) and unnecessary workload.OBJECTIVE:
To evaluate how well Canadian gastroenterologists adhere to colonoscopy surveillance guidelines after adenoma removal or treatment for CRC.METHODS:
Patients with a history of adenomas or CRC who had surveillance performed between October 2008 and October 2010 were retrospectively included. Time intervals between index colonoscopy and surveillance were compared with the 2008 guideline recommendations of the American Gastroenterological Association and regarded as appropriate when the surveillance interval was within six months of the recommended time interval.RESULTS:
A total of 265 patients were included (52% men; mean age 58 years). Among patients with a normal index colonoscopy (n=110), 42% received surveillance on time, 38% too early (median difference = 1.2 years too early) and 20% too late (median difference = 1.0 year too late). Among patients with nonadvanced adenomas at index (n=96), 25% underwent surveillance on time, 61% too early (median difference = 1.85) and 14% too late (median difference = 1.1). Among patients with advanced neoplasia at index (n=59), 29% underwent surveillance on time, 34% too early (median difference = 1.86) and 37% later than recommended (median difference = 1.61). No significant difference in adenoma detection rates was observed when too early surveillance versus appropriate surveillance (34% versus 33%; P=0.92) and too late surveillance versus appropriate surveillance (21% versus 33%; P=0.11) were compared.CONCLUSION:
Only a minority of surveillance colonoscopies were performed according to guideline recommendations. Deviation from the guidelines did not improve the adenoma detection rate. Interventions aimed at improving adherence to surveillance guidelines are needed. 相似文献10.
Joseph J Eron David A Cooper Roy T Steigbigel Bonaventura Clotet Jose M Gatell Princy N Kumar Jurgen K Rockstroh Mauro Schechter Martin Markowitz Patrick Yeni Mona R Loutfy Adriano Lazzarin Jeffrey L Lennox Kim M Strohmaier Hong Wan Richard JO Barnard Bach-Yen T Nguyen Hedy Teppler 《The Lancet infectious diseases》2013,13(7):587-596