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1.
Marco N. Iannone Stefano Stucchi Elia A. Turolla Chiara Beretta Samuele Ciceri Clizia Chinello Lisa Pagani Sergio Todde Patrizia Ferraboschi 《Journal of labelled compounds & radiopharmaceuticals》2022,65(3):48-62
In the last decade, the development of new radiopharmaceuticals for the imaging and therapy of prostate cancer has been a highly active and important area of research, especially focusing on the prostate-specific membrane antigen (PSMA), an antigen which is upregulated in prostate, as well as in other tumor cells. A large variety of PSMA ligands have been radiolabeled, to date. Among the various derivatives, PSMA-617 resulted to be one of the most interesting in terms of interaction with the antigen and clinical properties, and its lutetium-177 labeled version has recently been approved by regulatory agencies for therapeutic purposes. For this reasons, the radiolabeling with fluorine-18 of a PSMA-617 derivative might be of interest. Beside other methodologies to radiolabel macromolecules with fluorine-18, the “click-chemistry” approach resulted to be very useful, and the copper-catalyzed azide-alkyne cycloaddition (CuAAC) is considered one of most efficient and reliable. This paper proposes the synthesis of a suitable precursor for the radiolabeling with fluorine-18 of a new PSMA-617 derivative. The whole radiosynthetic procedure has been fully automated, and the final product, which proved to be stable in plasma, has been obtained with radiochemical yield and purity suitable for subsequent preclinical studies. 相似文献
2.
Alex S. Aires Leici M. Reichert Rodrigo T. Müller Marco B. Andrade 《Anatomical record (Hoboken, N.J. : 2007)》2022,305(9):2079-2098
The notarium is a rigid bony structure, which resulted from the fusion of thoracic vertebrae of some pterosaurs and birds. It is high variable, ranging from two to six fused thoracic vertebrae. In this study, we reviewed and analyzed approximately 270 specimens of neornithine birds (representing 80% of the living orders) and some fossils in order to identify the number of fused vertebrae, degree and sites of vertebral fusion, occurrence of sutures, and other structures of potential phylogenetic and functional significance. These data were analyzed using a recent time-calibrated molecular phylogenetic tree and principal component analyses analysis evaluating the relationship with long bones in order to reconstruct macroevolutionary trends related to the evolution of the notarium. The occurrence of this structure shows a mosaic distribution over neornithine phylogeny, originating several times independently, especially during the Paleogene, in predominantly ground-dwelling forms. The notarium of these groups is characterized by: neural spines fused into single structure, intervertebral openings small to absent, large ventral keels forming ventral plates, and fused transverse processes. Derived neornithines, such as aquatic forms and long-legged birds, have a tendency to display a decreased degree of fusion between the vertebrae, which may indicate a reduction or disappearance of the notarium. 相似文献
3.
Slonimsky Einat Upham Kent Pepley Sarah Ouyang Tao King Tonya Fiorelli Marco Thamburaj Krishnamoorthy 《Emergency radiology》2022,29(3):427-435
Emergency Radiology - In subarachnoid hemorrhage, noncontrast CT features are used to guide the localization of ruptured aneurysms on CT angiography and DSA. Multiplanar CT may improve the... 相似文献
4.
Andrea Ronchi MD Marco Montella MD Federica Zito Marino BD PhD Giuseppe Argenziano MD PhD Elvira Moscarella MD Gabriella Brancaccio MD Giuseppe Ferraro MD Giovanni Francesco Nicoletti MD Teresa Troiani MD Renato Franco MD PhD Immacolata Cozzolino MD PhD 《Cancer cytopathology》2022,130(1):18-29
Malignant melanoma (MM) is a highly aggressive neoplasm with a growing worldwide incidence. It is not uncommon that the disease is already metastatic at the time of the first diagnosis. Regional lymph nodes and skin are the first and most common metastatic sites, followed by distant visceral sites (lungs, liver, and central nervous system) and bone. In this clinical setting, fine-needle aspiration (FNA) often represents the first diagnostic approach. FNA is a useful tool to obtain a rapid and accurate diagnosis, in conjunction with ancillary techniques and molecular analysis, as recommended by recent guidelines. The aim of this review was to describe the cytomorphology, immunocytochemical tools, and molecular tools used for the diagnosis of MM metastases on FNA. 相似文献
5.
Russo Vincenzo Bottino Roberta D’Andrea Antonello Silverio Angelo Di Maio Marco Golino Paolo Nigro Gerardo Valsecchi Orazio Attena Emilio Canonico Mario Enrico Galasso Gennaro Parodi Guido Scudiero Fernando 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2022,36(4):705-712
Cardiovascular Drugs and Therapy - The clinical course of COVID-19 may be complicated by acute respiratory distress syndrome (ARDS) and thromboembolic events, which are associated with high risk of... 相似文献
6.
Benenati Stefano Toma Matteo Canale Claudia Vergallo Rocco Bona Roberta Della Ricci Davide Canepa Marco Crimi Gabriele Santini Francesco Ameri Pietro Porto Italo 《Heart failure reviews》2022,27(3):927-934
Heart Failure Reviews - To compare the efficacy and safety of different mechanical circulatory support (MCS) devices in CS. A total of 24 studies (7 randomized controlled... 相似文献
7.
Borlandelli Elena Ciaffi Jacopo Festuccia Gianluca Facchini Giancarlo Miceli Marco Brusi Veronica Mancarella Luana Lisi Lucia Di Martino Alberto Faldini Cesare Meliconi Riccardo Ursini Francesco 《Clinical rheumatology》2022,41(2):483-490
Clinical Rheumatology - Osteitis condensans ilii (OCI) is a benign condition characterised by triangular sclerosis of the iliac bone which may mimic radiographic sacroiliitis. Prevalence is... 相似文献
8.
Tardella Marika Di Carlo Marco Carotti Marina Ceccarelli Luca Giovagnoni Andrea Salaffi Fausto 《Inflammopharmacology》2022,30(3):705-712
Inflammopharmacology - To examine the effectiveness of Janus-kinase inhibitors (JAKis) or abatacept (ABA) in patients with rheumatoid arthritis-interstitial lung disease (RA-ILD). Patients with... 相似文献
9.
Gianluca Voglino Maria Rosaria Gualano Giuseppina Lo Moro Pietro Forghieri Marco Caprioli Heba Safwat Mhmoued Abdo Elhadidy Fabrizio Bert Roberta Siliquini 《Journal of community psychology》2022,50(1):601-619
This study aimed to assess depression, anxiety, posttraumatic stress disorder (PTSD) and discrimination in African migrants and investigate determinants. A cross-sectional study was conducted in Italy (July 2019–February 2020). Inclusion criteria: being a citizen of an African country or having parents who are citizens of an African country. Questionnaires included tests for depression, anxiety, PTSD, discrimination. Multivariable regressions were performed. Participants were 293. The prevalence of depression, anxiety, and PTSD was: 12.1%, 12.1%, and 24.4%. Only 7.2% declared not to be discriminated. Among significantly associated factors, waiting for/being in possession of temporary permits and discrimination were associated with all mental outcomes. Being (or having parents from) Sub-Saharan Africa increased the likelihood of discrimination. A relevant prevalence of mental illnesses was reported. Particularly, Sub-Saharan Africans potentially offer a unique point of view. Migrants' mental health should be a priority for national and international programs of health monitoring. 相似文献
10.
Alessandra Allione Clara Viberti Ilaria Cotellessa Chiara Catalano Elisabetta Casalone Giovanni Cugliari Alessia Russo Simonetta Guarrera Dario Mirabelli Carlotta Sacerdote Marco Gentile Fabian Eichelmann Matthias B. Schulze Sophia Harlid Anne Kirstine Eriksen Anne Tjønneland Martin Andersson Martijn E.T. Dollé Heleen Van Puyvelde Elisabete Weiderpass Miguel Rodriguez-Barranco Antonio Agudo Alicia K. Heath María-Dolores Chirlaque Thérèse Truong Dzevka Dragic Gianluca Severi Sabina Sieri Torkjel M. Sandanger Eva Ardanaz Paolo Vineis Giuseppe Matullo 《International journal of cancer. Journal international du cancer》2023,152(4):725-737
Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer mainly caused by asbestos exposure. Specific and sensitive noninvasive biomarkers may facilitate and enhance screening programs for the early detection of cancer. We investigated DNA methylation (DNAm) profiles in MPM prediagnostic blood samples in a case-control study nested in the European Prospective Investigation into Cancer and nutrition (EPIC) cohort, aiming to characterise DNAm biomarkers associated with MPM. From the EPIC cohort, we included samples from 135 participants who developed MPM during 20 years of follow-up and from 135 matched, cancer-free, controls. For the discovery phase we selected EPIC participants who developed MPM within 5 years from enrolment (n = 36) with matched controls. We identified nine differentially methylated CpGs, selected by 10-fold cross-validation and correlation analyses: cg25755428 (MRI1), cg20389709 (KLF11), cg23870316, cg13862711 (LHX6), cg06417478 (HOOK2), cg00667948, cg01879420 (AMD1), cg25317025 (RPL17) and cg06205333 (RAP1A). Receiver operating characteristic (ROC) analysis showed that the model including baseline characteristics (age, sex and PC1wbc) along with the nine MPM-related CpGs has a better predictive value for MPM occurrence than the baseline model alone, maintaining some performance also at more than 5 years before diagnosis (area under the curve [AUC] < 5 years = 0.89; AUC 5-10 years = 0.80; AUC >10 years = 0.75; baseline AUC range = 0.63-0.67). DNAm changes as noninvasive biomarkers in prediagnostic blood samples of MPM cases were investigated for the first time. Their application can improve the identification of asbestos-exposed individuals at higher MPM risk to possibly adopt more intensive monitoring for early disease identification. 相似文献