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排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Hunter Theresa Grabner Michael Birt Julie Isenberg Keith Shan Mingyang Teng Chia-Chen Wu Jianmin Griffing Kirstin Lisse Jeffrey Curtis Jeffrey R. 《Clinical rheumatology》2022,41(9):2863-2874
Clinical Rheumatology - This study aimed to assess treatment patterns and frequency of inadequate response associated with advanced therapy initiation among patients with ankylosing spondylitis... 相似文献
2.
Johnson Derek Richard Glenn Chad Allan Javan Ramin Olson Jeffrey James 《Journal of neuro-oncology》2022,158(2):139-165
Journal of Neuro-Oncology - These recommendations apply to adults with glioblastoma who have been previously treated with first-line radiation or chemoradiotherapy and who are suspected of... 相似文献
3.
Jung Nathalie Namjoshi Sarika Mohammed Yousuf Grice Jeffrey E. Benson Heather A. E. Raney Sam G. Roberts Michael S. Windbergs Maike 《Pharmaceutical research》2022,39(5):935-948
Pharmaceutical Research - The quality testing and approval procedure for most pharmaceutical products is a streamlined process with standardized procedures for the determination of critical quality... 相似文献
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Fournier Jay C. Forand Nicholas R. Wang Zheng Li Zhexuan Iyengar Satish DeRubeis Robert J. Shelton Richard Amsterdam Jay Jarrett Robin B. Vittengl Jeffrey R. Segal Zindel Dimidjian Sona Shea M. Tracie Dobson Keith S. Hollon Steven D. 《Cognitive therapy and research》2022,46(3):517-531
Cognitive Therapy and Research - Baseline severity has emerged as a key predictor of acute response to treatments for depression. The goals of this individual patient data meta-analysis were to... 相似文献
6.
Lukas Rimas V. Thakkar Jigisha P. Cristofanilli Massimo Chandra Sunandana Sosman Jeffrey A. Patel Jyoti D. Kumthekar Priya Stupp Roger Lesniak Maciej S. 《Journal of neuro-oncology》2022,156(3):443-452
Journal of Neuro-Oncology - Leptomeningeal metastases (LM) constitute an involvement of cancer which is associated with marked morbidity and mortality. The contemporary diagnostic and therapeutic... 相似文献
7.
Investigating the effects of compound paralogous EPHB receptor mutations on mouse facial development
Sarah T. Mincer Terren K. Niethamer Teng Teng Jeffrey O. Bush Christopher J. Percival 《Developmental dynamics》2022,251(7):1138-1155
Background: Variation in facial shape may arise from the combinatorial or overlapping actions of paralogous genes. Given its many members, and overlapping expression and functions, the EPH receptor family is a compelling candidate source of craniofacial morphological variation. We performed a detailed morphometric analysis of an allelic series of E14.5 Ephb1-3 receptor mutants to determine the effect of each paralogous receptor gene on craniofacial morphology. Results: We found that Ephb1, Ephb2, and Ephb3 genotypes significantly influenced facial shape, but Ephb1 effects were weaker than Ephb2 and Ephb3 effects. Ephb2−/− and Ephb3−/− mutations affected similar aspects of facial morphology, but Ephb3−/− mutants had additional facial shape effects. Craniofacial differences across the allelic series were largely consistent with predicted additive genetic effects. However, we identified a potentially important nonadditive effect where Ephb1 mutants displayed different morphologies depending on the combination of other Ephb paralogs present, where Ephb1+/−, Ephb1−/−, and Ephb1−/−; Ephb3−/− mutants exhibited a consistent deviation from their predicted facial shapes. Conclusions: This study provides a detailed assessment of the effects of Ephb receptor gene paralogs on E14.5 mouse facial morphology and demonstrates how the loss of specific receptors contributes to facial dysmorphology. 相似文献
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Xinwen Zhang Delphis F. Levia Elvis Osamudiamhen Ebikade Jeffrey Chang Dionisios G. Vlachos Changqing Wu 《Journal of applied toxicology : JAT》2022,42(3):423-435
Lignin and lignin-based materials have received considerable attention in various fields due to their promise as sustainable feedstocks. Guaiacol (G) and syringol (S) are two primary monolignols that occur in different ratios for different plant species. As methoxyphenols, G and S have been targeted as atmospheric pollutants and their acute toxicity examined. However, there is a rare understanding of the toxicological properties on other endpoints and mixture effects of these monolignols. To fill this knowledge gap, our study investigated the impact of different S/G ratios (0.5, 1, and 2) and three lignin depolymerization samples from poplar, pine, and miscanthus species on mutagenicity and developmental toxicity. A multitiered method consisted of in silico simulation, in vitro Ames test, and in vivo chicken embryonic assay was employed. In the Ames test, syringol showed a sign of mutagenicity, whereas guaiacol did not, which agreed with the T.E.S.T. simulation. For three S and G mixture and lignin monomers, mutagenic activity was related to the proportion of syringol. In addition, both S and G showed developmental toxicity in the chicken embryonic assay and T.E.S.T. simulation, and guaiacol had a severe effect on lipid peroxidation. A similar trend and comparable developmental toxicity levels were detected for S and G mixtures and the three lignin depolymerized monomers. This study provides data and insights on the differential toxicity of varying S/G ratios for some important building blocks for bio-based materials. 相似文献