全文获取类型
收费全文 | 2040篇 |
免费 | 123篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 35篇 |
儿科学 | 66篇 |
妇产科学 | 36篇 |
基础医学 | 154篇 |
口腔科学 | 82篇 |
临床医学 | 148篇 |
内科学 | 604篇 |
皮肤病学 | 21篇 |
神经病学 | 84篇 |
特种医学 | 106篇 |
外科学 | 416篇 |
综合类 | 47篇 |
一般理论 | 4篇 |
预防医学 | 111篇 |
眼科学 | 57篇 |
药学 | 92篇 |
中国医学 | 2篇 |
肿瘤学 | 113篇 |
出版年
2023年 | 17篇 |
2022年 | 18篇 |
2021年 | 92篇 |
2020年 | 49篇 |
2019年 | 46篇 |
2018年 | 63篇 |
2017年 | 51篇 |
2016年 | 68篇 |
2015年 | 66篇 |
2014年 | 91篇 |
2013年 | 116篇 |
2012年 | 147篇 |
2011年 | 165篇 |
2010年 | 107篇 |
2009年 | 92篇 |
2008年 | 125篇 |
2007年 | 126篇 |
2006年 | 79篇 |
2005年 | 103篇 |
2004年 | 74篇 |
2003年 | 71篇 |
2002年 | 74篇 |
2001年 | 17篇 |
2000年 | 14篇 |
1999年 | 15篇 |
1998年 | 39篇 |
1997年 | 27篇 |
1996年 | 26篇 |
1995年 | 23篇 |
1994年 | 17篇 |
1993年 | 16篇 |
1992年 | 4篇 |
1991年 | 5篇 |
1990年 | 7篇 |
1989年 | 15篇 |
1988年 | 9篇 |
1987年 | 8篇 |
1986年 | 7篇 |
1985年 | 9篇 |
1984年 | 11篇 |
1983年 | 6篇 |
1982年 | 11篇 |
1981年 | 13篇 |
1980年 | 11篇 |
1979年 | 2篇 |
1978年 | 8篇 |
1977年 | 9篇 |
1976年 | 4篇 |
1975年 | 2篇 |
1967年 | 1篇 |
排序方式: 共有2178条查询结果,搜索用时 187 毫秒
1.
Babiker Hani M. Milhem Mohammed Aisner Joseph Edenfield William Shepard Dale Savona Michael Iyer Swaminathan Abdelrahim Maen Beach C. L. Skikne Barry Laille Eric Tsai Kao-Tai Ho Thai 《Cancer chemotherapy and pharmacology》2020,85(3):621-626
Cancer Chemotherapy and Pharmacology - CC-486 is an oral formulation of azacitidine that allows for extended dosing schedules to prolong azacitidine exposure to malignant cells and maximize... 相似文献
2.
The impact of age on prognosis in patients with gastric cancer: experience in a tertiary care centre
Maan El Halabi Renee Horanieh Hani Tamim Deborah Mukherji Sara Jdiaa Sally Temraz Ali Shamseddine Kassem Barada 《Journal of gastrointestinal oncology.》2020,11(6):1233
BackgroundGastric cancer (GC) is a leading cause of cancer-related death in the world and most patients have advanced disease upon presentation. The effect of age on prognosis in GC is controversial. We aimed to determine the impact of age on survival in patients with GC.MethodsThis was a retrospective study of the medical records of Lebanese patients diagnosed with GC at the American University of Beirut Medical Center (AUBMC) between 2005 and 2014. Patients were divided into young (<65 years) and older groups (≥65 years). A multivariate analysis was done to determine the independent predictors of survival. Kaplan-Meier method was used for analysis of long-term survival outcomes.ResultsThe sample consisted of 156 patients. The mean age was 62.15 (SD 13.54). Most patients presented with stage 4 disease (62.2%) and poorly differentiated histology (66.4%). The most common symptoms were abdominal pain and weight loss. On bivariate analysis, advanced stage (P=0.02) and higher grade (P=0.04) were associated with increased mortality. Patients <65 years of age were significantly more likely to have poorly differentiated tumours, while patients ≥65 years had more comorbidities (P=0.001). The 5-year DFS were 35% and 37% for patients <65 years of age and ≥65 years of age, respectively (P=0.15).ConclusionsHigher grade and advanced stage are associated with worse survival in patients with GC, but age did not seem to have an impact. Screening high risk patients and early diagnosis are necessary to improve survival. 相似文献
3.
4.
Background: In ordinary circumstances, objective structured clinical examination (OSCE) is a resource-intensive assessment method. In case of developing and implementing multidisciplinary OSCE, there is no doubt that the cost will be greater.Aim: Through this study a research project was conducted to develop, implement and evaluate a multidisciplinary OSCE model within limited resources.Methods: This research project went through the steps of blueprinting, station writing, resources reallocation, implementation and finally evaluation.Results: The developed model was implemented in the Primary Health Care (PHC) program which is one of the pillars of the Community-Based undergraduate curriculum of the Faculty of Medicine, Suez Canal University (FOM-SCU). Data for evaluation of the implemented OSCE model were derived from two resources. First, feedback of the students and assessors through self-administered questionnaires was obtained. Second, evaluation of the OSCE psychometrics was done. The deliverables of this research project included a set of validated integrated multi-disciplinary and low cost OSCE stations with an estimated reliability index of 0.6.Conclusion: After having this experience, we have a critical mass of faculty members trained on blueprinting and station writing and a group of trained assessors, facilitators and role players. Also there is a state of awareness among students on how to proceed in this type of OSCE which renders future implementation more feasible. 相似文献
5.
Amrallah A. Mohammed Abdullah S. Al-Zahrani Mian U. Farooq Hafez M. Ghanem Lobna A. Abdelaziz Hani M. EL-Khatib 《Indian journal of hematology & blood transfusion》2015,31(4):439-445
Venous thromboembolism (VTE) represents one of the most important causes of morbidity and mortality in cancer patients. This investigation was undertaken to investigate the natural history of VTE in the oncology center in a tertiary care hospital. We did a retrospective study on cancer patients who presented to King Abdullah Medical city in Holly capital; a tertiary care hospital; from May 2011 to June 2013. Follow up period was calculated from time of VTE diagnosis till the last clinical visit or till patient death. Among 1,678 cancer patients, 132 (7.87 %) were diagnosed with VTE. The median patient age was 53.5 years, with female to male ratio 1.3/1. Thirty one patients (23.5 %) were diagnosed with VTE and cancer simultaneously, seventy four patients (56.1 %) were on chemotherapy and twenty eight patients (21.2 %) were on best supportive care.VTE were symptomatic in 110 patients (83.3 %) and asymptomatic in 22 patients (16.7 %). Lower limbs were the commonest site (42.4 %) with the highest incidence in patients with advanced stages (93 %). Forty nine (37 %) patients were receiving LMWH as prophylaxis. Median survival in months for patients with VTE prophylaxis versus without prophylactic, and asymptomatic versus symptomatic were (12.6 vs 6.3; p 0.12 and 9.8 vs 12.4; p 0.885, respectively). There is underutilization of thromboprophylaxis in our region, which needs more effort to reduce VTE burden. Also we need large prospective studies to clarify the impact of VTE symptoms and presentation on patient’s survival. 相似文献
6.
Yahya A. Al-Zahrani Sameer E. Al-Harthi Lateef M. Khan Hani M. El-Bassossy Sherif M. Edris Mai A. Alim A. Sattar 《Saudi Pharmaceutical Journal》2015,23(5):487-498
The anti-anginal effects of allopurinol were assessed in experimental model rats of angina and their effects were evaluated with amlodipine. In the vasopressin-induced angina model, oral administration of allopurinol in dose of 10 mg/kg revealed remarkably analogous effects in comparison with amlodipine such as dose-dependent suppression of vasopressin-triggered time, duration and severity of ST depression. In addition, allopurinol produced dose dependent suppression of plasma Malondialdehyde (MDA) level, systolic blood pressure, cardiac contractility and cardiac oxygen consumption; while in contrast, amlodipine minimally suppressed the elevation of plasma MDA level. Endothelial NO synthase (eNOS) expression, serum nitrate were strikingly increased, however lipid profile was significantly reduced. Seemingly, allopurinol was found to be more potent than amlodipine – a calcium channel antagonist. To conclude, it was explicitly observed and verified that on the ischemic electrocardiography (ECG) changes in angina pectoris model in rats, allopurinol exerts a significant protective effects, reminiscent of enhancement of vascular oxidative stress, function of endothelial cells, improved coronary blood flow in addition to the potential enhancement in myocardial stress. Moreover, our findings were in conformity with several human studies. 相似文献
7.
8.
9.