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1.
The physiologic variations of serum lipids inthe residents in urban districts of Beijing from birth to senescence were studied by standardized me- thods. 15 208 were profiled for serum total choles- terol and 5 585 for high-density lipoprotein choles- terol and triglyceride. The average serum lipids of neonates were similar to those reported by other authors over the world. The characteristic sex and age differences of total and low-density lipoprotein cholesterol showed a striking similarity to those re- ported by the Lipid Research Clinic, USA, but the mean values were much lower in Beijing residents. However, Beijing boys and men had higher high- density lipoprotein cholesterol than American coun- terparts. The cholesterol and triglyceride reached top levels at age 60-80 and declined after 80. The nonagenarians had similar lipid levels as middle- aged adults. The definition of hypercholesterolemia was discussed briefly. The lipid risk level for coro- nary heart disease of Beijing populations was es- timated.  相似文献
2.
Surgical treatment of trigeminal neurinomas.   总被引:6,自引:1,他引:5  
ObjectiveToinvestigatethebestsurgicalapproachfortheremovaloftrigeminalneurinomas(TNs).MethodsAretrospectiveanalysisof75patien...  相似文献
3.
低分子肝素对糖尿病大鼠早期肾脏病变的防护作用   总被引:5,自引:0,他引:5  
Guo H  Gan L  Yu Z 《Zhonghua yi xue za zhi》2001,81(21):1327-1329
目的探讨低分子肝素对实验性糖尿病大鼠早期肾脏病变的防护作用及机制.方法将大鼠随机分为正常对照组、糖尿病组和低分子肝素治疗组,每组各30只大鼠.分别于1、2、4周测定肌酐清除率、尿白蛋白、肾重、体重、肾脏肥大指数、部分凝血酶时间(APTT)和抗Xa因子活性,观察肾脏组织病理变化并进行体视学分析.结果低分子肝素治疗组于实验期间体重高于糖尿病组,第2、4周肌酐清除率分别为4.01 ml/min±0.39 ml/min及2.20 ml/min±0.34 ml/min;第4周尿24 h白蛋白为9.6 μg±3.0 μg,明显低于糖尿病组(P<0.05).APTT于治疗第2、4周分别为20.88 s和21.01 s,较糖尿病组延长(P<0.01),肾组织病理较糖尿病组有所改善.而两组血糖无明显差异(P>0.05).低分子肝素治疗组的肾脏肥大指数于1、2、4周分别为0.67±0.06,0.69±0.06、0.73±0.07(×102),高于糖尿病组(P<0.05).肾小球平均面积和体积密度于第4周时略高于糖尿病组,但无统计学意义.结论低分子肝素对糖尿病大鼠早期肾脏病变有一定程度的防护作用,其机制可能与改善肾小球内血液动力学有关.  相似文献
4.
体外循环时间对胃粘膜Pco2,胃粘膜pH的影响   总被引:2,自引:0,他引:2  
将16例心内直视手术病人按体外循环(CPB)时间分为短于100min(A组)及超过100min(B组)两组,以观察CPB时间对胃粘膜Pco2及胃粘膜pH(pHi)的影响。结果显示,停机前两组病人胃粘膜Pco2显著增高,pHi显著降低,尤以B组为著。术后A组未见并发症,B组3例病人发生致命并发症,其中1例死亡。提示低温CPB时间越长,胃粘膜酸中毒越重,术后可能发生致命并发症。  相似文献
5.
马桑内酯点燃大鼠海马脑片CA1区的双脉冲...   总被引:1,自引:0,他引:1  
Paired-pulse depression (PPD) technique was used to investigate the potency of recurrent synaptic inhibition mediated by GABA in area CA1 of 54 hippocampal slices from coriaria lactone (CL)-kindled and control rats. When paired stimuli were sent to the axon of CA1 pyramidal cell and Schaffer collaterals, the effect of population spike PPD lasted about 40-60ms; no significant change was observed on PPD potency between kindled and control groups (P = 0.06, 2-way ANOVA). The results indicate that the GABA-ergic synaptic inhibition seemed not to play a key role in the maintenance of the chemical kindling induced by CL.  相似文献
6.
单抗HIM82对中性粒细胞ROS损伤RBC的保护作用   总被引:1,自引:1,他引:0  
目的研究单抗HIM82(30 μg/ml)是否能对PMA激活PMN后产生的ROS进行降调节,进而降低ROS对红细胞的损伤,验证HIM82对RBC损伤有无保护作用.方法用PMA激活PMN后产生的ROS对无HIM82和加HIM82保护的RBC进行损伤实验.结果加HIM82保护后的RBC膜蛋白乙酰胆碱酯酶(AchE)活性由损伤时的(71.36±22.15)%恢复到(87.60±14.78)%(n=6 P<0.001),活性提高了16.30%;对RBC膜脂质过氧化损伤的保护作用使损伤率从(52.42±20.63)%减小到(23.81±12.40)%(n=9 P<0.01),脂质过氧化损伤降低了54.57%,RBC膜脆性损伤用溶血率表示,溶血率由(80.76±20.23)%下降到(66.30±7.08)%(n=6 P<0.001),下降了17.90%.结论单抗HIM82不仅能明显地降低PMN的ROS水平也能有效保护周围红细胞,可能对防治多种趋化因子激活PMN引起的ROS损伤提供一种新的有效途径..  相似文献
7.
Diabeticneuropathy(DNP)isahighlydebilitatingcomplicationfordiabeticindividuals.Unfortunately,thepathogenesisofDNPisstilpoorly...  相似文献
8.
ThefirstsucesfulintracavernoussurgerywasperformedbyBrowder1in1937.Sincethen,thehighrateofsurgicalmorbidityandmortalityasocia...  相似文献
9.
Mitoxantrone (DHAQ) is a new anti-cancer agent. The ion-pair HPLC method to determine mitoxantrone hydrochloride injection was proposed. Mitoxantrone can be separated on Zorbax-ODS column with methanol-water-formic acid (450:50:1.5) containing 3.605g SDS as mobile phase. The pH of mobile phase was adjusted to 2.7. The flow rate was 1.0 ml/min and detection was at wavelength of 254 nm, providing a detection limit of 1ng (r/n, 3:1) of DHAQ. DHAQ was determined by peak area measurement with ametantrone as internal standard. The rectilinear calibration graph in the range of 1-10 micrograms of DHAQ was obtained (r = 0.999 2). The average recovery was 99.62 +/- 2.36% (n = 10), and the results were not interfered by the other ingredients in the injection.  相似文献
10.
The authors report the establishment of a human myeloma cell line--KM-2R--and its preliminary use in human-human hybridoma research. KM-2R cells are resistant to both 6-TG and ouabain. Their doubling time is about 30 h. They have a modal chromosome number of 81-85. Using ELISA and immunodiffusion techniques, gamma-heavy and kappa-light chains were detected in the concentrated cell culture supernatant. KM-2R cells are sensitive to HAT medium. When fusing with normal human spleen cells, tonsil cells, and B lymphoblasts transformed by EB virus, fusion frequencies of 20-60% resulted.  相似文献
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