全文获取类型
收费全文 | 9779篇 |
免费 | 667篇 |
国内免费 | 40篇 |
专业分类
耳鼻咽喉 | 69篇 |
儿科学 | 224篇 |
妇产科学 | 173篇 |
基础医学 | 1285篇 |
口腔科学 | 288篇 |
临床医学 | 745篇 |
内科学 | 2191篇 |
皮肤病学 | 186篇 |
神经病学 | 785篇 |
特种医学 | 969篇 |
外科学 | 1695篇 |
综合类 | 65篇 |
一般理论 | 1篇 |
预防医学 | 516篇 |
眼科学 | 141篇 |
药学 | 505篇 |
1篇 | |
中国医学 | 8篇 |
肿瘤学 | 639篇 |
出版年
2023年 | 95篇 |
2022年 | 91篇 |
2021年 | 317篇 |
2020年 | 230篇 |
2019年 | 279篇 |
2018年 | 344篇 |
2017年 | 206篇 |
2016年 | 286篇 |
2015年 | 332篇 |
2014年 | 390篇 |
2013年 | 419篇 |
2012年 | 643篇 |
2011年 | 615篇 |
2010年 | 425篇 |
2009年 | 343篇 |
2008年 | 516篇 |
2007年 | 527篇 |
2006年 | 526篇 |
2005年 | 525篇 |
2004年 | 421篇 |
2003年 | 359篇 |
2002年 | 352篇 |
2001年 | 117篇 |
2000年 | 109篇 |
1999年 | 105篇 |
1998年 | 78篇 |
1997年 | 77篇 |
1996年 | 49篇 |
1995年 | 53篇 |
1994年 | 61篇 |
1993年 | 47篇 |
1992年 | 55篇 |
1991年 | 64篇 |
1990年 | 79篇 |
1989年 | 48篇 |
1988年 | 49篇 |
1987年 | 59篇 |
1986年 | 39篇 |
1985年 | 48篇 |
1984年 | 42篇 |
1983年 | 28篇 |
1982年 | 27篇 |
1981年 | 35篇 |
1979年 | 29篇 |
1978年 | 26篇 |
1977年 | 27篇 |
1975年 | 24篇 |
1974年 | 30篇 |
1932年 | 36篇 |
1923年 | 26篇 |
排序方式: 共有10000条查询结果,搜索用时 140 毫秒
1.
Die Anaesthesiologie - Die Intensive Care Unit-Acquired Weakness (ICUAW) stellt eine der häufigsten neuromuskulären Komplikationen in der Intensivmedizin dar. Besonders bei... 相似文献
2.
3.
Bernice Y. Yan Sandra Garcet Nicholas Gulati Felix Kiecker Judilyn Fuentes‐Duculan Patricia Gilleaudeau Mary Sullivan‐Whalen Avner Shemer Hiroshi Mitsui James G. Krueger 《Experimental dermatology》2019,28(1):35-44
Dysplastic naevi (DN) are benign lesions with atypical features intermediate between that of common melanocytic naevi (CMN) and malignant melanoma (MM). Debate remains over whether DN represent progressive lesions from CMN. Through gene expression profiling and analysis of molecular gene signatures, our study revealed progressive increases in immune activation and regulation, along with pathways implicated in melanomagenesis, from CMN to DN to MM. Using criteria of 1.5‐fold change and false discovery rate ≤0.05, we found differential expression of 7186 probes (6370 unique genes) with the largest difference detected between DN and MM from the standpoint of genomic melanoma progression. Despite progressive increases in the T‐helper type 1 (Th1)‐inducing gene (IL‐12), RT‐PCR indicated impaired Th1 or cytotoxic T‐cell response (decreased IFN‐γ) in MM. Concordantly, our results indicated progressive increases in molecular markers associated with regulatory T cells, exhausted T cells and tolerogenic dendritic cells, including detection of increased expression of suppressor of cytokine signalling 3 (SOCS3) in dendritic cells associated with MM. All together, our findings suggest that the increased immunosuppressive microenvironment of melanoma may contribute to unhampered proliferation of neoplastic cells. In addition, the detection of increased markers associated with tolerogenic dendritic cells in MM suggests that targeting these suppressive immune cell types may represent an alternative avenue for future immunotherapy. 相似文献
4.
Marco Bandini Sebastiano Nazzani Michele Marchioni Felix Preisser Zhe Tian Marco Moschini Firas Abdollah Nazareno Suardi Markus Graefen Francesco Montorsi Shahrokh F. Shariat Fred Saad Alberto Briganti Pierre I. Karakiewicz 《Clinical genitourinary cancer》2019,17(1):72-78.e4
Background
The rate of noninterventional treatment (NIT) in prostate cancer (PCa) active surveillance (AS) candidates is on the rise. However, contemporary data are unavailable. We described community-based NIT rates within 16 Surveillance Epidemiology and End Results (SEER) registries between 2010 and 2014.Patients and Methods
We identified 23,360 PCa patients who fulfilled the University of California San Francisco AS criteria (prostate-specific antigen [PSA] < 10 ng/mL, clinical T stage ≤ T2a, Gleason score ≤ 6, and positive cores < 33%). Annual NIT rates as well as patient distribution according to PSA, age, number of positive cores, and clinical T stage were studied. Multivariable logistic regression analysis tested NIT predictors.Results
Between 2010 and 2014, the NIT rate increased from 30.2% to 57.5% (P = .004). Within 16 SEER registries, NIT rates ranged from 25.9% to 62%. NIT rate increased uniformly within all examined registries. Of patient and tumor characteristics (PSA > 4 ng/mL, cT2a and > 1 positive core) only the proportion of NIT patients aged < 65 years increased over time from 47.3% to 53.2% (P = .03). By multivariable logistic regression analysis predicting NIT rate, older age (odd ratio [OR] = 1.05), more contemporary year of diagnosis (OR = 1.41), and being unmarried (OR = 1.45) and uninsured (OR = 2.41) were independent predictors.Conclusion
The NIT rate has markedly increased across all examined SEER registries. Nonetheless, important differences distinguish those who received high-end NIT from low-end NIT. PCa characteristics of NIT patients remained unchanged over time. However, in addition to geographical differences in NIT rates, patient characteristics such as age, marital status, and insurance status represent potential NIT access barriers. 相似文献5.
Zöllner Johann Philipp Paule Esther Wagner Marlies Freiman Thomas M. Rosenow Felix Strzelczyk Adam 《Zeitschrift für Epileptologie》2020,33(1):15-21
Clinical Epileptology - Temporale Enzephalozelen sind bisher nur in wenigen Fällen als Ursache von symptomatischen Epilepsien beschrieben worden. Zunehmende Beschreibungen in Fallserien weisen... 相似文献
6.
Ashley S. Felix Eric M. McLaughlin Bette J. Caan David E. Cohn Garnet L. Anderson Electra D. Paskett 《International journal of cancer. Journal international du cancer》2020,147(2):404-412
In the Women's Health Initiative (WHI) Life and Longevity After Cancer (LILAC) cohort, we examined predictors of guideline-concordant treatment among endometrial cancer (EC) survivors and associations between receipt of guideline-concordant treatment and survival. Receipt of guideline-concordant EC treatment was defined according to year-specific National Comprehensive Cancer Network (NCCN) guidelines. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for predictors of guideline-concordant treatment receipt. We estimated multivariable-adjusted hazard ratios (HRs) and 95% CIs for relationships between guideline-concordant treatment and overall survival using Cox proportional hazards regression. We included 629 women with EC, of whom 83.6% (n = 526) received guideline-concordant treatment. Receipt of guideline-concordant treatment was less common among women with nonendometrioid histology (OR = 0.24, 95% CI = 0.13–0.45) but was more common among women living in the Midwest (OR = 2.09, 95% CI = 1.06–4.12) or West (OR = 3.02, 95% CI = 1.49–6.13) compared to the Northeast. In Cox regression models adjusted for age, histology and stage, receipt of guideline-concordant EC treatment was borderline associated with improved overall survival (HR = 0.80, 95% CI = 0.60–1.01) in the overall population. Guideline-concordant treatment was also linked with better overall survival among women with low-grade uterine-confined endometrioid EC or widely metastatic endometrioid EC. Guideline-concordant treatment varies by some patient characteristics and those women in receipt of guideline-concordant care had borderline improved survival. Studies evaluating regional differences in treatment along with randomized clinical trials to determine appropriate treatment regimens for women with aggressive tumor characteristics are warranted. 相似文献
7.
Elise Roger Cedric Pichat Laurent Torlay Olivier David Felix Renard Sonja Banjac Arnaud Atty Lorella Minotti Laurent Lamalle Philippe Kahane Monica Baciu 《Human brain mapping》2020,41(3):779-796
Mesial temporal lobe epilepsy (mTLE) affects the brain networks at several levels and patients suffering from mTLE experience cognitive impairment for language and memory. Considering the importance of language and memory reorganization in this condition, the present study explores changes of the embedded language‐and‐memory network (LMN) in terms of functional connectivity (FC) at rest, as measured with functional MRI. We also evaluate the cognitive efficiency of the reorganization, that is, whether or not the reorganizations support or allow the maintenance of optimal cognitive functioning despite the seizure‐related damage. Data from 37 patients presenting unifocal mTLE were analyzed and compared to 48 healthy volunteers in terms of LMN‐FC using two methods: pairwise correlations (region of interest [ROI]‐to‐ROI) and graph theory. The cognitive efficiency of the LMN‐FC reorganization was measured using correlations between FC parameters and language and memory scores. Our findings revealed a large perturbation of the LMN hubs in patients. We observed a hyperconnectivity of limbic areas near the dysfunctional hippocampus and mainly a hypoconnectivity for several cortical regions remote from the dysfunctional hippocampus. The loss of FC was more important in left mTLE (L‐mTLE) than in right (R‐mTLE) patients. The LMN‐FC reorganization may not be always compensatory and not always useful for patients as it may be associated with lower cognitive performance. We discuss the different connectivity patterns obtained and conclude that interpretation of FC changes in relation to neuropsychological scores is important to determine cognitive efficiency, suggesting the concept of “connectome” would gain to be associated with a “cognitome” concept. 相似文献
8.
9.