全文获取类型
收费全文 | 10174篇 |
免费 | 398篇 |
国内免费 | 33篇 |
专业分类
耳鼻咽喉 | 110篇 |
儿科学 | 306篇 |
妇产科学 | 231篇 |
基础医学 | 1113篇 |
口腔科学 | 255篇 |
临床医学 | 631篇 |
内科学 | 2138篇 |
皮肤病学 | 200篇 |
神经病学 | 990篇 |
特种医学 | 261篇 |
外国民族医学 | 1篇 |
外科学 | 1283篇 |
综合类 | 21篇 |
一般理论 | 2篇 |
预防医学 | 1263篇 |
眼科学 | 483篇 |
药学 | 809篇 |
中国医学 | 28篇 |
肿瘤学 | 480篇 |
出版年
2023年 | 22篇 |
2021年 | 48篇 |
2020年 | 36篇 |
2019年 | 61篇 |
2018年 | 108篇 |
2017年 | 70篇 |
2016年 | 78篇 |
2015年 | 112篇 |
2014年 | 121篇 |
2013年 | 186篇 |
2012年 | 687篇 |
2011年 | 829篇 |
2010年 | 242篇 |
2009年 | 176篇 |
2008年 | 778篇 |
2007年 | 860篇 |
2006年 | 832篇 |
2005年 | 878篇 |
2004年 | 843篇 |
2003年 | 773篇 |
2002年 | 697篇 |
2001年 | 546篇 |
2000年 | 644篇 |
1999年 | 296篇 |
1998年 | 53篇 |
1997年 | 26篇 |
1996年 | 40篇 |
1995年 | 19篇 |
1994年 | 14篇 |
1993年 | 20篇 |
1992年 | 49篇 |
1991年 | 35篇 |
1990年 | 34篇 |
1989年 | 32篇 |
1988年 | 41篇 |
1987年 | 29篇 |
1986年 | 23篇 |
1985年 | 28篇 |
1984年 | 8篇 |
1983年 | 19篇 |
1982年 | 12篇 |
1979年 | 18篇 |
1978年 | 9篇 |
1977年 | 9篇 |
1975年 | 9篇 |
1974年 | 16篇 |
1973年 | 8篇 |
1971年 | 7篇 |
1970年 | 14篇 |
1968年 | 11篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Balázs Nemes Réka P. Szabó Dávid Péntek Ildikó Nagy Gergely Ivády Bettina Kárai Eszter Szánthó Zsuzsa Hevessy Sándor Sipka Gergő J. Szőllősi Sándor Baráth 《Transplantation proceedings》2021,53(5):1423-1432
IntroductionThe usage of extended-criteria donors (ECD) became a routinely accepted manner in the last decade. ECD is a potential risk factor for antibody-mediated rejection. Analysis of lymphocyte subsets might be a complementary diagnostic toolkit because there is limited knowledge about this term.MethodBetween May 12, 2016, and September 4, 2019, a total of 130 patients who had undergone kidney transplant were investigated. Patients were divided in ECD and standard criteria donor (SCD) groups. Blood samples were collected before the operation, then in the first week and after 30, 60, 180, and 365 days. Besides routine laboratory tests, multicolor flow cytometry was performed for lymphocyte subsets.ResultsECD grafts were transplanted to older recipients. The number of CD4+ cells increased in the SCDs from the first week to until the end of first month, and then decreased. The number of CD4+ cells decreased from the beginning of the study until the end of first year to 66% of its original value in ECDs. At the first month, the number of CD19+ cells was higher in SCD compared with ECD cases; the number then decreased in both groups. T-regulatory cells had a drop at the first week that lasted until the first month. A bigger increase in SCD and a moderate increase in ECD group were then observed. The kinetics of CD19+ and CD19+ naive cells are similar in the ECD and SCD groups. In the SCD group, cell count decreased in both CD19+ (13%) and CD19+ naive (12%) between third and sixth month. The count of CD19+ cells decreased by 9%, but the count of CD19+ naive cells increased by 11% between the sixth month and first year.DiscussionThe prolonged postoperative uremic state caused by the poorer initial function, together with an aging immune system, explains the weaker immune response in ECD patients, which may be the cause of the decreased number of memory and regulatory T cells. Older patients with an ECD graft need a tailored, personalized, and less aggressive immunosuppressive treatment. 相似文献
2.
3.
Velázquez-Pérez Luis Medrano-Montero Jacqueline Rodríguez-Labrada Roberto Canales-Ochoa Nalia Campins Alí Jandy Carrillo Rodes Frank J Rodríguez Graña Tania Hernández Oliver María O. Aguilera Rodríguez Raul Domínguez Barrios Yennis Torres Vega Reydenis Flores Angulo Lissi Cordero Navarro Noharis Y. Sigler Villanueva Aldo A. Gámez Rodríguez Osiel Sagaró Zambrano Ilya Navas Napóles Nayime Y. García Zacarías Javier Serrano Barrera Orlando R. Ramírez Bautista María B. Estupiñán Rodríguez Annelié Guerra Rondón Leonardo A. Vázquez-Mojena Yaimeé González-Zaldivar Yanetza Almaguer Mederos Luis E. Leyva-Mérida Alejandro 《Cerebellum (London, England)》2020,19(2):252-264
The Cerebellum - The prevalence estimations of hereditary ataxias are biased since most epidemiological studies are confined to isolated geographical regions and few nationwide studies are... 相似文献
4.
5.
6.
Background: Chronic migraine is a common, highly disabling, underdiagnosed and undertreated entity of migraine. It affects 0.9%–2.2% of the general adult population. The present paper overviews the preclinical and clinical data regarding the therapeutic effect of onabotulinumtoxinA in chronic migraineurs. Methods: A literature search was conducted in the database of PubMed up to 20 May 2015 for articles related to the pathomechanism of chronic migraine, the mode of action, and the efficacy, safety and tolerability of onabotulinumtoxinA for the preventive treatment of chronic migraine. Results: The pathomechanism of chronic migraine has not been fully elucidated. The mode of action of onabotulinumtoxinA in the treatment of chronic migraine is suggested to be related to the inhibition of the release of calcitonin gene-related peptide and substance P in the trigeminovascular system. Randomized clinical trials demonstrated that long-term onabotulinumtoxinA fixed-site and fixed-dose (155–195 U) intramuscular injection therapy was effective and well tolerated for the prophylactic treatment of chronic migraine. Conclusions: Chronic migraine is a highly devastating entity of migraine. Its exact pathomechanism is unrevealed. Two-third of chronic migraineurs do not receive proper preventive medication. Recent clinical studies revealed that onabotulinumtoxinA was an efficacious and safe treatment for chronic migraine. 相似文献
7.
8.
Pau Rocas Yolanda Fernández Natalia García-Aranda Laia Foradada Pilar Calvo Pablo Avilés María José Guillén Simó Schwartz Josep Rocas Fernando Albericio Ibane Abasolo 《Nanomedicine : nanotechnology, biology, and medicine》2018,14(2):257-267
Glutathione degradable polyurethane-polyurea nanoparticles (PUUa NP) with a disulfide-rich multiwalled structure and a cyclic RGD peptide as a targeting moiety were synthesized, incorporating a very lipophilic chemotherapeutic drug named Plitidepsin. In vitro studies indicated that encapsulated drug maintained and even improved its cytotoxic activity while in vivo toxicity studies revealed that the maximum tolerated dose (MTD) of Plitidepsin could be increased three-fold after encapsulation. We also found that pharmacokinetic parameters such as maximum concentration (Cmax), area under the curve (AUC) and plasma half-life were significantly improved for Plitidepsin loaded in PUUa NP. Moreover, biodistribution assays in mice showed that RGD-decorated PUUa NP accumulate less in spleen and liver than non-targeted conjugates, suggesting that RGD-decorated nanoparticles avoid sequestration by macrophages from the reticuloendothelial system. Overall, our results indicate that polyurethane-polyurea nanoparticles represent a very valuable nanoplatform for the delivery of lipophilic drugs by improving their toxicological, pharmacokinetic and whole-body biodistribution profiles. 相似文献
9.
Adaptation or recovery after health shocks? Evidence using subjective and objective health measures 下载免费PDF全文
In this paper, we analyse the effect of an onset of a health shock on subjective survival probability and compare it with objective survival probability and self‐reported health measures. In particular, we are interested in whether expectations of people respond to health shocks and whether these follow the evolution of objective life expectations and self‐reported health measures over time. Using longitudinal data from the Health and Retirement Study, we estimate fixed effects models of adaptation for the objective and subjective survival probabilities and for some self‐reported health measures. The results show that after cancer diagnosis, conditional on surviving, both the objective and subjective longevity and self‐reported health measures drift back to the before diagnosis trajectories. For stroke and heart attack, in spite of their persistent negative effect on survival, subjective life expectations and self‐reported health measures seem to indicate only a transient effect of the health shock. The differences between the objective and subjective measures are in line with the concept of adaptation. We discuss the policy implications of our results. 相似文献
10.