全文获取类型
收费全文 | 1323816篇 |
免费 | 101509篇 |
国内免费 | 4180篇 |
专业分类
耳鼻咽喉 | 16776篇 |
儿科学 | 43447篇 |
妇产科学 | 36341篇 |
基础医学 | 195957篇 |
口腔科学 | 35860篇 |
临床医学 | 128700篇 |
内科学 | 255031篇 |
皮肤病学 | 26320篇 |
神经病学 | 110911篇 |
特种医学 | 48082篇 |
外国民族医学 | 366篇 |
外科学 | 183371篇 |
综合类 | 28709篇 |
一般理论 | 460篇 |
预防医学 | 113187篇 |
眼科学 | 28891篇 |
药学 | 98477篇 |
6篇 | |
中国医学 | 3096篇 |
肿瘤学 | 75517篇 |
出版年
2019年 | 11568篇 |
2018年 | 16265篇 |
2017年 | 12266篇 |
2016年 | 13151篇 |
2015年 | 15158篇 |
2014年 | 20770篇 |
2013年 | 31995篇 |
2012年 | 44162篇 |
2011年 | 46806篇 |
2010年 | 27058篇 |
2009年 | 24909篇 |
2008年 | 42641篇 |
2007年 | 45001篇 |
2006年 | 45095篇 |
2005年 | 43515篇 |
2004年 | 41498篇 |
2003年 | 39406篇 |
2002年 | 38213篇 |
2001年 | 60720篇 |
2000年 | 62347篇 |
1999年 | 51915篇 |
1998年 | 13683篇 |
1997年 | 12259篇 |
1996年 | 12158篇 |
1995年 | 12353篇 |
1994年 | 11567篇 |
1993年 | 10826篇 |
1992年 | 41479篇 |
1991年 | 40739篇 |
1990年 | 39422篇 |
1989年 | 37312篇 |
1988年 | 34540篇 |
1987年 | 33667篇 |
1986年 | 32118篇 |
1985年 | 30619篇 |
1984年 | 22990篇 |
1983年 | 19524篇 |
1982年 | 11690篇 |
1981年 | 10221篇 |
1979年 | 20759篇 |
1978年 | 14769篇 |
1977年 | 12014篇 |
1976年 | 11833篇 |
1975年 | 12081篇 |
1974年 | 14774篇 |
1973年 | 14452篇 |
1972年 | 13349篇 |
1971年 | 12408篇 |
1970年 | 11472篇 |
1969年 | 10402篇 |
排序方式: 共有10000条查询结果,搜索用时 46 毫秒
1.
2.
S. M. White C. L. Shelton A. W. Gelb C. Lawson F. McGain J. Muret J. D. Sherman representing the World Federation of Societies of Anaesthesiologists Global Working Group on Environmental Sustainability in Anaesthesia 《Anaesthesia》2022,77(2):201-212
The Earth’s mean surface temperature is already approximately 1.1°C higher than pre-industrial levels. Exceeding a mean 1.5°C rise by 2050 will make global adaptation to the consequences of climate change less possible. To protect public health, anaesthesia providers need to reduce the contribution their practice makes to global warming. We convened a Working Group of 45 anaesthesia providers with a recognised interest in sustainability, and used a three-stage modified Delphi consensus process to agree on principles of environmentally sustainable anaesthesia that are achievable worldwide. The Working Group agreed on the following three important underlying statements: patient safety should not be compromised by sustainable anaesthetic practices; high-, middle- and low-income countries should support each other appropriately in delivering sustainable healthcare (including anaesthesia); and healthcare systems should be mandated to reduce their contribution to global warming. We set out seven fundamental principles to guide anaesthesia providers in the move to environmentally sustainable practice, including: choice of medications and equipment; minimising waste and overuse of resources; and addressing environmental sustainability in anaesthetists’ education, research, quality improvement and local healthcare leadership activities. These changes are achievable with minimal material resource and financial investment, and should undergo re-evaluation and updates as better evidence is published. This paper discusses each principle individually, and directs readers towards further important references. 相似文献
3.
Kinase alterations are increasingly recognised as oncogenic drivers in mesenchymal tumours. Infantile fibrosarcoma and the related renal tumour, congenital mesoblastic nephroma, were among the first solid tumours shown to harbour recurrent tyrosine kinase fusions, with the canonical ETV6::NTRK3 fusion identified more than 20 years ago. Although targeted testing has long been used in diagnosis, the advent of more robust sequencing techniques has driven the discovery of kinase alterations in an array of mesenchymal tumours. As our ability to identify these genetic alterations has improved, as has our recognition and understanding of the tumours that harbour these alterations. Specifically, this study will focus upon mesenchymal tumours harbouring NTRK or other kinase alterations, including tumours with an infantile fibrosarcoma-like appearance, spindle cell tumours resembling lipofibromatosis or peripheral nerve sheath tumours and those occurring in adults with a fibrosarcoma-like appearance. As publications describing the histology of these tumours increase so, too, do the variety kinase alterations reported, now including NTRK1/2/3, RET, MET, RAF1, BRAF, ALK, EGFR and ABL1 fusions or alterations. To date, these tumours appear locally aggressive and rarely metastatic, without a clear link between traditional features used in histological grading (e.g. mitotic activity, necrosis) and outcome. However, most of these tumours are amenable to new targeted therapies, making their recognition of both diagnostic and therapeutic import. The goal of this study is to review the clinicopathological features of tumours with NTRK and other tyrosine kinase alterations, discuss the most common differential diagnoses and provide recommendations for molecular confirmation with associated treatment implications. 相似文献
4.
5.
6.
Matthias Knefel PhD Elisabeth L. Zeilinger PhD Simone Lubowitzki PhD Katharina Krammer MSc Matthias Unseld MD Rupert Bartsch MD Thorsten Fuereder MD Ulrich Jäger MD Barbara Kiesewetter MD Maria Krauth MD Markus Raderer MD Philipp B. Staber MD Peter Valent MD Alexander Gaiger MD 《Cancer》2023,129(21):3466-3475
Background
Survival in cancer patients is associated with a multitude of biological, social, and psychological factors. Although it is well established that all these factors add to overall mortality, it is not well understood how the predictive power of these parameters changes in a comprehensive model and over time.Methods
Patients who attended the authors’ outpatient clinic were invited to participate. The authors followed 5180 mixed cancer patients (51.1% female; mean age, 59.1 years [SD = 13.8]) for up to 16 years and analyzed biological (age, sex, cancer site, anemia), psychological (anxiety, depression), and social variables (marital status, education, employment status) potentially predicting overall survival in a Cox proportional hazards model.Results
The median survival time for the entire sample was 4.3 years (95% confidence interval, 4.0–4.7). The overall survival probabilities for 1 and 10 years were 76.8% and 38.0%, respectively. Following an empirical approach, the authors split the time interval into five periods: acute, subacute, short-term, medium-term, and long-term. A complex pattern of variables predicted overall survival differently in the five periods. Biological parameters were important throughout most of the time, social parameters were either time-independent predictors or tended to be more important in the longer term. Of the psychological parameters, only depression was a significant predictor and lost its predictive power in the long-term.Conclusions
The findings of this study allow the development of comprehensive patient-specific models of risk and resilience factors addressing biopsychosocial needs of cancer patients, paving the way for a personalized treatment plan that goes beyond biomedical cancer care. 相似文献7.
8.
Zyuz’kov G. N. Zhdanov V. V. Miroshnichenko L. A. Polyakova T. Yu. Stavrova L. A. Simanina E. V. Minakova M. Yu. Agafonov V. I. Churin A. A. 《Bulletin of experimental biology and medicine》2022,173(5):615-619
Bulletin of Experimental Biology and Medicine - The psychopharmacological effects of a stimulator of functions of progenitor cells of the nervous tissue STAT3 inhibitor (STAT3 Inhibitor XIV, LLL12)... 相似文献
9.
10.