全文获取类型
收费全文 | 2308篇 |
免费 | 125篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 62篇 |
儿科学 | 59篇 |
妇产科学 | 21篇 |
基础医学 | 384篇 |
口腔科学 | 72篇 |
临床医学 | 210篇 |
内科学 | 296篇 |
皮肤病学 | 116篇 |
神经病学 | 224篇 |
特种医学 | 120篇 |
外科学 | 361篇 |
综合类 | 23篇 |
预防医学 | 109篇 |
眼科学 | 39篇 |
药学 | 90篇 |
中国医学 | 1篇 |
肿瘤学 | 256篇 |
出版年
2023年 | 11篇 |
2021年 | 35篇 |
2020年 | 23篇 |
2019年 | 40篇 |
2018年 | 35篇 |
2017年 | 40篇 |
2016年 | 38篇 |
2015年 | 55篇 |
2014年 | 73篇 |
2013年 | 102篇 |
2012年 | 119篇 |
2011年 | 119篇 |
2010年 | 78篇 |
2009年 | 70篇 |
2008年 | 114篇 |
2007年 | 113篇 |
2006年 | 86篇 |
2005年 | 113篇 |
2004年 | 106篇 |
2003年 | 98篇 |
2002年 | 108篇 |
2001年 | 68篇 |
2000年 | 64篇 |
1999年 | 69篇 |
1998年 | 26篇 |
1997年 | 20篇 |
1996年 | 22篇 |
1995年 | 20篇 |
1994年 | 13篇 |
1993年 | 10篇 |
1992年 | 27篇 |
1991年 | 34篇 |
1990年 | 39篇 |
1989年 | 34篇 |
1988年 | 30篇 |
1987年 | 26篇 |
1986年 | 29篇 |
1985年 | 18篇 |
1984年 | 25篇 |
1983年 | 15篇 |
1979年 | 15篇 |
1978年 | 11篇 |
1977年 | 10篇 |
1975年 | 16篇 |
1974年 | 12篇 |
1973年 | 10篇 |
1971年 | 12篇 |
1970年 | 12篇 |
1969年 | 18篇 |
1967年 | 9篇 |
排序方式: 共有2443条查询结果,搜索用时 17 毫秒
1.
Distinct genetic alterations and luminal molecular subtype in nested variant of urothelial carcinoma
2.
Behzad Bidadi Andrea Watson Brenda Weigel Andre Oliveira Justin Kirkham Carola Arndt 《Pediatric blood & cancer》2020,67(6)
Infantile myofibromatosis (IM) is characterized by solitary musculoskeletal nodules presenting during infancy but can manifest as multiple lesions with visceral involvement. Multicentric IM with visceral involvement carries a high risk of mortality and there is no consensus on treatment. We present a case of a patient with multicentric IM and pulmonary involvement who progressed on several chemotherapeutic regimens and subsequently had a complete response to sorafenib and later imatinib. This report describes the novel use of sorafenib and imatinib to treat generalized IM and the role of continued tyrosine kinase inhibitor therapy to maintain remission. 相似文献
3.
Sahker Ethan Lancianese Donna A. Jones DeShauna Arndt Stephan 《International journal of mental health and addiction》2020,18(1):138-148
International Journal of Mental Health and Addiction - Healthcare settings frequently rank among the lowest for referring clients to substance use disorder (SUD) treatment. Screening, Brief... 相似文献
4.
Lina Jansen Lars Schwettmann Christian Behr Andrea Eberle Bernd Holleczek Christina Justenhoven Hiltraud Kajüter Kirsi Manz Frederik Peters Ron Pritzkuleit Andrea Schmidt-Pokrzywniak Eunice Sirri Fabian Tetzlaff Sven Voigtländer Volker Arndt 《International journal of cancer. Journal international du cancer》2023,153(10):1784-1796
Age-standardized cancer incidence has decreased over the last years for many cancer sites in developed countries. Whether these trends led to narrowing or widening socioeconomic inequalities in cancer incidence is unknown. Using cancer registry data covering 48 million inhabitants in Germany, the ecological association between age-standardized total and site specific (colorectal, lung, prostate and breast) cancer incidence in 2007 to 2018 and a deprivation index on district level (aggregated to quintiles) was investigated. Incidence in the most and least deprived districts were compared using Poisson models. Average annual percentage changes (AAPCs) and differences in AAPCs between deprivation quintiles were assessed using Joinpoint regression analyses. Age-standardized incidence decreased strongly between 2007 and 2018 for total cancer and all cancer sites (except female lung cancer), irrespective of the level of deprivation. However, differences in the magnitude of trends across deprivation quintiles resulted in increasing inequalities over time for total cancer, colorectal and lung cancer. For total cancer, the incidence rate ratio between the most and least deprived quintile increased from 1.07 (95% confidence interval: 1.01-1.12) to 1.23 (1.12-1.32) in men and from 1.07 (1.01-1.13) to 1.20 (1.14-1.26) in women. Largest inequalities were observed for lung cancer with 82% (men) and 88% (women) higher incidence in the most vs the least deprived regions in 2018. The observed increase in inequalities in cancer incidence is in alignment with trends in inequalities in risk factor prevalence and partly utilization of screening. Intervention programs targeted at socioeconomically deprived and urban regions are highly needed. 相似文献
5.
Maike Wellbrock Claudia Spix Cécile M Ronckers Desiree Grabow Anna-Liesa Filbert Arndt Borkhardt Daniel Wollschläger Friederike Erdmann 《International journal of cancer. Journal international du cancer》2023,153(4):742-755
Childhood cancer is the leading disease-related cause of death among under 15 year olds in Europe. Since primary preventive measures are lacking, improving survival probabilities and long-term well-being remain primary goals. With this report, we provide the first long-term assessment and interpretation of patterns in childhood cancer survival in Germany, covering a period of 30 years. Using data from the German Childhood Cancer Registry, we assessed temporal patterns of cancer survival among children (0-14 years) diagnosed in Germany from 1991 to 2016, by cancer type, age at diagnosis and sex. We calculated overall survival (OS) and average annual percentage changes of the respective 5-year OS estimates. OS improved across all cancer types, age groups as well as for boys and girls over time. Five-year OS for all childhood cancers combined increased from 77.8% in 1991-1995 to 86.5% in 2011-2016, with stronger improvements during the early 1990s. The most pronounced survival improvement was seen for acute myeloid leukaemia, at 2% annually and 5-year OS recently reaching 81.5%. Survival improvements for some diagnoses such as neuroblastoma, renal tumours and bone tumours have flattened out. Tremendous enhancements in diagnostics, treatment and supportive care have affected average survival improvements for most cancer types. Recently, survival improvements have decelerated overall and for some cancer types, it plateaued at an unsatisfactory level. As not all children benefited equally from the survival improvements, personal factors (eg, socioeconomic circumstances, health literacy, access to care) likely affect individual prognosis and warrant further investigation. 相似文献
6.
7.
Julia Menke Kerstin Amann Lorenzo Cavagna Maria Blettner Arndt Weinmann Andreas Schwarting Vicki R. Kelley 《Journal of the American Society of Nephrology : JASN》2015,26(2):379-389
A noninvasive means to predict the onset and recurrence of lupus nephritis (LN) before overt renal injury is needed to optimize and individualize treatment. Colony-stimulating factor-1 (CSF-1) is expressed by kidney tubules at the onset of LN, increases with disease progression, and spills into the circulation in lupus-prone mice. We tested the hypothesis that amplified expression of CSF-1 detected in the serum or urine correlates with intrarenal CSF-1 expression and histopathology (increased macrophage accumulation, activity indices) and clinical kidney disease activity and predicts the onset and recurrence of nephritis in patients with systemic lupus erythematosus (SLE). We found increased serum or urine CSF-1 levels in patients with cutaneous, serositis, and musculoskeletal disease; however, the increase in CSF-1 levels was far greater in LN. Moreover, an elevation in serum or urine CSF-1 levels correlated with increasing intrarenal CSF-1 expression and histopathology. By longitudinally tracking patients, we found that elevated serum CSF-1 heralded the initial onset of disease, and a rise in serum or urine CSF-1 predicted recurrences of LN before clinical evidence of glomerular dysfunction and conventional serologic measures, even in patients with other manifestations of SLE. These findings indicate that serial monitoring for a rise in serum or urine CSF-1 levels in patients with SLE reflects kidney histopathology and may predict renal disease activity and the onset and recurrence of LN more accurately than conventional laboratory measures. 相似文献
8.
Iván Sánchez Fernández Nicholas S. Abend Daniel H. Arndt Jessica L. Carpenter Kevin E. Chapman Karen M. Cornett Dennis J. Dlugos William B. Gallentine Christopher C. Giza Joshua L. Goldstein Cecil D. Hahn Jason T. Lerner Joyce H. Matsumoto Kristin McBain Kendall B. Nash Eric Payne Sarah M. Sánchez Korwyn Williams Tobias Loddenkemper 《The Journal of pediatrics》2014
9.
Guentsch A Kramesberger M Sroka A Pfister W Potempa J Eick S 《Journal of periodontology》2011,82(7):1051-1060
Background: The analysis of samplings from periodontal pockets is important in the diagnosis and therapy of periodontitis. In this study, three different sampling techniques were compared to determine whether one method yielded samples suitable for the reproducible and simultaneous determination of bacterial load, cytokines, neutrophil elastase, and arginine‐specific gingipains (Rgps). Rgps are an important virulence factor of Porphyromonas gingivalis, the exact concentration of which in gingival crevicular fluid (GCF) has not been quantified. Methods: GCF was sampled from four sites per patient (one sample per quadrant using two samples per method) in 36 patients with chronic periodontitis. One week later, the procedure was repeated with alternative methods. Variables determined were loads of Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans) and P. gingivalis, levels of interleukin‐6 and ‐8, activity of neutrophil elastase, and level of Rgps. Results: The detected cytokine levels were higher using paper strips compared to paper points. Bacteria were found in similar loads from paper strips and paper points. Rgps were only detectable in high quantities by washing the periodontal pocket. The level of Rgps correlated with the load of P. gingivalis. Conclusions: The use of paper strips was suitable for the simultaneous determination of microbial and immunologic parameters. Obtaining GCF by washing can be useful for special purposes. The gingipain concentration in periodontal pockets was directly determined to be ≤1.5 μM. This value indicated that most of the substrates of these proteases by in vitro assays identified until now can be easily degraded in P. gingivalis–infected sites. 相似文献
10.
Priv.-Doz. Dr. Arndt Klocke J?rn Kemper Dirk Schulze Gerhard Adam B?rbel Kahl-Nieke 《Journal of orofacial orthopedics》2005,66(4):279-287
AbstractBackground: Orthodontic appliances pose a potential risk during magnetic resonance imaging (MRI) due to forces on metallic objects within the static magnetic field of MRI systems. The aim of the present investigation was to measure forces on orthodontic wires caused by the static magnetic field of a 1.5-Tesla MRI system, and to assess the safety hazards associated with these forces.Materials and Methods: Thirty-two different orthodontic wires (21 arch wires, eight ligature wires and three retainer wires) were investigated in a 1.5-Tesla MRI system (Magnetom Symphony, Siemens Medical Solutions, Erlangen, Germany). The translational forces were measured using the deflection angle test (ASTM F2052-02); rotational forces were assessed on a 5-point qualitative scale.Results and Conclusion: All retainer wires and the steel arch wires (the Noninium® arch wire being the exception) were subjected to considerable rotational and translational forces within the MRI system’s magnetic field. Translational forces were from 9.1- to 27.6-times as high as gravitational forces on these objects. Steel ligature wires and arch wires made of cobalt chromium, titanium molybdenum, nickel-titanium, and brass alloys showed no or negligible forces within the magnetic field. The translational and rotational forces within the MRI magnetic field should pose no risk to carefully-ligated arch wires. Steel retainer wire bonds should be checked to ensure secure attachment prior to an MRI investigation.* both authors share first authorship 相似文献