全文获取类型
收费全文 | 12894篇 |
免费 | 1263篇 |
国内免费 | 789篇 |
专业分类
耳鼻咽喉 | 138篇 |
儿科学 | 136篇 |
妇产科学 | 118篇 |
基础医学 | 1600篇 |
口腔科学 | 215篇 |
临床医学 | 1671篇 |
内科学 | 1821篇 |
皮肤病学 | 329篇 |
神经病学 | 763篇 |
特种医学 | 674篇 |
外国民族医学 | 5篇 |
外科学 | 1706篇 |
综合类 | 1758篇 |
一般理论 | 4篇 |
预防医学 | 822篇 |
眼科学 | 243篇 |
药学 | 1346篇 |
3篇 | |
中国医学 | 700篇 |
肿瘤学 | 894篇 |
出版年
2024年 | 10篇 |
2023年 | 160篇 |
2022年 | 207篇 |
2021年 | 459篇 |
2020年 | 433篇 |
2019年 | 444篇 |
2018年 | 435篇 |
2017年 | 402篇 |
2016年 | 385篇 |
2015年 | 584篇 |
2014年 | 790篇 |
2013年 | 729篇 |
2012年 | 1001篇 |
2011年 | 1055篇 |
2010年 | 703篇 |
2009年 | 527篇 |
2008年 | 709篇 |
2007年 | 776篇 |
2006年 | 676篇 |
2005年 | 671篇 |
2004年 | 462篇 |
2003年 | 552篇 |
2002年 | 480篇 |
2001年 | 384篇 |
2000年 | 299篇 |
1999年 | 245篇 |
1998年 | 178篇 |
1997年 | 148篇 |
1996年 | 136篇 |
1995年 | 110篇 |
1994年 | 95篇 |
1993年 | 71篇 |
1992年 | 85篇 |
1991年 | 90篇 |
1990年 | 61篇 |
1989年 | 78篇 |
1988年 | 47篇 |
1987年 | 52篇 |
1986年 | 41篇 |
1985年 | 29篇 |
1984年 | 25篇 |
1983年 | 15篇 |
1982年 | 9篇 |
1981年 | 12篇 |
1980年 | 9篇 |
1979年 | 12篇 |
1978年 | 7篇 |
1977年 | 10篇 |
1976年 | 5篇 |
1975年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
Conan MacDougall Theora Canonica Chris Keh Binh An P. Phan Janice Louie 《Pharmacotherapy》2022,42(4):343-361
Rifamycins (rifampin, rifabutin, and rifapentine) play an essential role in the treatment of mycobacterial and some nonmycobacterial infections. They also induce the activity of various drug transporting and metabolizing enzymes, which can impact the concentrations and efficacy of substrates. Many anticoagulant and antiplatelet (AC/AP) agents are substrates of these enzymes and have narrow therapeutic indices, leading to risks of thrombosis or bleeding when coadministered with rifamycins. The objective of this systematic review was to evaluate the effects on AC/AP pharmacokinetics, laboratory markers, and clinical safety and efficacy of combined use with rifamycins. A systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidance was performed. The PubMed, Embase, and Web of Science databases were queried for English-language reports on combination use of rifamycins and AC/AP agents from database inception through August 2021. The 29 studies identified examined warfarin (n = 17), direct oral anticoagulants (DOACs) (n = 8), and antiplatelet agents (n = 4) combined with rifampin (n = 28) or rifabutin (n = 1). Eleven studies were case reports or small case series; 14 reported on pharmacokinetic or laboratory markers in healthy volunteers. Rifampin-warfarin combinations led to reductions in warfarin area under the curve (AUC) of 15%–74%, with variability by warfarin isomer and study. Warfarin dose increases of up to 3–5 times prerifampin doses were required to maintain coagulation parameters in the therapeutic range. DOAC AUCs were decreased by 20%–67%, with variability by individual agent and with rifampin versus rifabutin. The active metabolite of clopidogrel increased substantially with rifampin coadministration, whereas prasugrel was largely unaffected and ticagrelor saw decreases. Our review suggests most combinations of AC/AP agents and rifampin are problematic. Further studies are required to determine whether rifabutin or rifapentine could be safe alternatives for coadministration with AC/AP drugs. 相似文献
5.
6.
7.
Wenjing Tang Ying Dou Tao Qin Yuan Ding Xuemei Tang Xiaodong Zhao Yunfei An 《Scandinavian journal of immunology》2019,89(6)
DOCK8 immunodeficiency syndrome (DIDS) is a combined immunodeficiency characterized by recurrent viral infections, severe atopy and early onset malignancy. Immunological abnormalities include lymphopenia, CD8+ T‐cell cytoskeleton dysfunction, defective B cell memory and variable serum immunoglobulin levels. Here, we analyse the B cell receptor repertoire (BCR) characteristics and antibody avidity of four DIDS patients, attempt to understand the dysregulated humoral immunity in DIDS patients with a normal antibody titre and suggest a scientific basis for intravenous immunoglobulin (IVIG) replacement therapy for these patients. We analysed BCR characteristics, including somatic hypermutation (SHM) frequency, using deep sequencing of multiplex PCR products derived from BCR heavy chain CDR3 regions from DIDS patients and controls. The antibody avidity of human tetanus and hemophilus influenza B antibodies was determined by ELISA using thiocyanate elution. IVIG replacement treatment and infection conditions were investigated retrospectively. We found skewing of the BCR repertoire and decreased antibody avidity in patients with DIDS. DIDS patients had fewer negatively charged amino acids than healthy controls. The SHM frequency of the IGHV3 gene was lower in patients with DIDS. Patients received regular IVIG therapy, resulting in fewer and less severe infections. We conclude that although IgG levels are normal in most DIDS patients, IVIG replacement therapy is still necessary. 相似文献
8.
9.
Yun An Chen Julie A. Mack Dipti M. Karamchandani Michael P. Zaleski Liyan Xu Daleela G. Dodge Alison L. Chetlen 《The breast journal》2019,25(2):232-236
We investigate the clinical history, past medical history, and risk status in women with benign intraductal papillomas(IDP). We observed an upgrade rate of 3.9% to ductal carcinoma in situ (DCIS) and upgrade rate of 10.7% to a high‐risk lesion. Prior or concurrent atypia or cancer and high‐risk status had a significant increase risk of upgrade. Surgical excision of papillomas is recommended especially in high‐risk patients and women with concurrent or history of atypia or malignancy. 相似文献
10.