全文获取类型
收费全文 | 4037篇 |
免费 | 220篇 |
国内免费 | 35篇 |
专业分类
耳鼻咽喉 | 43篇 |
儿科学 | 53篇 |
妇产科学 | 51篇 |
基础医学 | 513篇 |
口腔科学 | 118篇 |
临床医学 | 298篇 |
内科学 | 1279篇 |
皮肤病学 | 88篇 |
神经病学 | 349篇 |
特种医学 | 96篇 |
外科学 | 594篇 |
综合类 | 21篇 |
一般理论 | 1篇 |
预防医学 | 185篇 |
眼科学 | 68篇 |
药学 | 243篇 |
中国医学 | 8篇 |
肿瘤学 | 284篇 |
出版年
2023年 | 28篇 |
2022年 | 41篇 |
2021年 | 88篇 |
2020年 | 61篇 |
2019年 | 73篇 |
2018年 | 108篇 |
2017年 | 68篇 |
2016年 | 81篇 |
2015年 | 104篇 |
2014年 | 157篇 |
2013年 | 184篇 |
2012年 | 274篇 |
2011年 | 282篇 |
2010年 | 166篇 |
2009年 | 151篇 |
2008年 | 281篇 |
2007年 | 296篇 |
2006年 | 263篇 |
2005年 | 299篇 |
2004年 | 276篇 |
2003年 | 251篇 |
2002年 | 208篇 |
2001年 | 26篇 |
2000年 | 20篇 |
1999年 | 23篇 |
1998年 | 26篇 |
1997年 | 21篇 |
1996年 | 26篇 |
1995年 | 42篇 |
1994年 | 30篇 |
1993年 | 25篇 |
1992年 | 28篇 |
1991年 | 20篇 |
1990年 | 18篇 |
1989年 | 10篇 |
1988年 | 12篇 |
1987年 | 18篇 |
1986年 | 10篇 |
1985年 | 7篇 |
1984年 | 20篇 |
1983年 | 18篇 |
1982年 | 18篇 |
1981年 | 9篇 |
1980年 | 7篇 |
1979年 | 6篇 |
1977年 | 9篇 |
1976年 | 6篇 |
1975年 | 10篇 |
1957年 | 5篇 |
1944年 | 5篇 |
排序方式: 共有4292条查询结果,搜索用时 15 毫秒
1.
Aldo Cannata Silvia Cantoni Antonio Sciortino Giuseppe Bruschi Claudio Francesco Russo 《Journal of the American College of Cardiology》2021,77(18):2323-2334
Mechanical intravascular hemolysis is frequently observed following procedures on heart valves and uncommonly observed in native valvular disease. In most cases, its severity is mild. Nevertheless, it can be clinically significant and even life threatening, requiring multiple blood transfusions and renal replacement therapy. This paper reviews the current knowledge on mechanical intravascular hemolysis in valvular disease, before and after correction, focusing on pathophysiology, approach to diagnosis, and impact of other hematological conditions on the resultant anemia. The importance of a multidisciplinary management is underscored. Laboratory data are provided about subclinical hemolysis that is commonly observed following the implantation of surgical and transcatheter valve prostheses and devices. Finally, clinical scenarios are reviewed and current medical and surgical treatments are discussed, including alternative options for inoperable patients. 相似文献
2.
Rizzo Manglio Miguel Bluthgen Mara Virginia Recondo Gonzalo Naveira Martin Perfetti Aldo Rizzi Florencia Kuzminin Alejandro Faura Victoria Cerini Matas Videla Alejandro Silva Carlos Lupinacci Lorena Minatta Nicols 《International journal of clinical oncology / Japan Society of Clinical Oncology》2021,26(6):1057-1064
International Journal of Clinical Oncology - Immune-checkpoint inhibitors (ICIs) are standard treatments for metastatic non-small cell lung cancer (NSCLC). Patients with poor performance status... 相似文献
3.
4.
5.
Ebadi Maryam Bhanji Rahima A. Mazurak Vera C. Montano-Loza Aldo J. 《Journal of gastroenterology》2019,54(10):845-859
Journal of Gastroenterology - Sarcopenia (severe muscle depletion) is a prevalent muscle abnormality in patients with cirrhosis that confers poor prognosis both pre- and post-liver transplantation.... 相似文献
6.
Emmi Helle Aldo Córdova-Palomera Tiina Ojala Priyanka Saha Praneetha Potiny Stefan Gustafsson Erik Ingelsson Michael Bamshad Deborah Nickerson Jessica X. Chong University of Washington Center for Mendelian Genomics Euan Ashley James R. Priest 《Genetic epidemiology》2019,43(2):215-226
Loss of function variants in NOTCH1 cause left ventricular outflow tract obstructive defects (LVOTO). However, the risk conferred by rare and noncoding variants in NOTCH1 for LVOTO remains largely uncharacterized. In a cohort of 49 families affected by hypoplastic left heart syndrome, a severe form of LVOTO, we discovered predicted loss of function NOTCH1 variants in 6% of individuals. Rare or low-frequency missense variants were found in 16% of families. To make a quantitative estimate of the genetic risk posed by variants in NOTCH1 for LVOTO, we studied associations of 400 coding and noncoding variants in NOTCH1 in 1,085 cases and 332,788 controls from the UK Biobank. Two rare intronic variants in strong linkage disequilibrium displayed significant association with risk for LVOTO amongst European-ancestry individuals. This result was replicated in an independent analysis of 210 cases and 68,762 controls of non-European and mixed ancestry. In conclusion, carrying rare predicted loss of function variants in NOTCH1 confer significant risk for LVOTO. In addition, the two intronic variants seem to be associated with an increased risk for these defects. Our approach demonstrates the utility of population-based data sets in quantifying the specific risk of individual variants for disease-related phenotypes. 相似文献
7.
8.
Susanna Zanutto Chiara Maura Ciniselli Antonino Belfiore Mara Lecchi Enzo Masci Gabriele Delconte Massimo Primignani Giulia Tosetti Marco Dal Fante Linda Fazzini Aldo Airoldi Marcello Vangeli Francesca Turpini Giovanni Giuseppe Rubis Passoni Paolo Viaggi Monica Arena Roberta Ilaria Olimpia Motta Anna Maria Cantù Cristiano Crosta Giuseppe De Roberto Francesca Iannuzzi Andrea Cassinotti Valentina Dall'Olio Laura Tizzoni Gabriella Sozzi Emanuele Meroni Luigi Bisanti Marco Alessandro Pierotti Paolo Verderio Manuela Gariboldi 《International journal of cancer. Journal international du cancer》2020,146(4):1164-1173
Colorectal cancer (CRC) screening programs help diagnose cancer precursors and early cancers and help reduce CRC mortality. However, currently recommended tests, the fecal immunochemical test (FIT) and colonoscopy, have low uptake. There is therefore a pressing need for screening strategies that are minimally invasive and consequently more acceptable to patients, most likely blood based, to increase early CRC identification. MicroRNAs (miRNAs) released from cancer cells are detectable in plasma in a remarkably stable form, making them ideal cancer biomarkers. Using plasma samples from FIT-positive (FIT+) subjects in an Italian CRC screening program, we aimed to identify plasma circulating miRNAs that detect early CRC. miRNAs were initially investigated by quantitative real-time PCR in plasma from 60 FIT+ subjects undergoing colonoscopy at Fondazione IRCCS Istituto Nazionale dei Tumori, then tested on an internal validation cohort (IVC, 201 cases) and finally in a large multicenter prospective series (external validation cohort [EVC], 1121 cases). For each endoscopic lesion (low-grade adenoma [LgA], high-grade adenoma [HgA], cancer lesion [CL]), specific signatures were identified in the IVC and confirmed on the EVC. A two-miRNA-based signature for CL and six-miRNA signatures for LgA and HgA were selected. In a multivariate analysis including sex and age at blood collection, the areas under the receiver operating characteristic curve (95% confidence interval) of the signatures were 0.644 (0.607–0.682), 0.670 (0.626–0.714) and 0.682 (0.580–0.785) for LgA, HgA and CL, respectively. A miRNA-based test could be introduced into the FIT+ workflow of CRC screening programs so as to schedule colonoscopies only for subjects likely to benefit most. 相似文献
9.
10.