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Douglas Drak Nishanta Tangirala Michael Fink Leon A. Adams Jonathan Fawcett Gary P. Jeffrey Mandy Byrne Geoffrey McCaughan Steve Chadban Kate Wyburn Germaine Wong Wai H. Lim David M. Gracey 《Transplantation proceedings》2021,53(1):136-140
AimRates of simultaneous liver and kidney transplantation (SLKT) have increased, but indications for SLKT remain poorly defined. Additional data are needed to determine which patients benefit from SLKT to best direct use of scarce donor kidneys.MethodsData were extracted from the Australia and New Zealand Dialysis and Transplant Registry (ANZDATA) database for all SLKT performed until the end of 2017. Patients were divided by pretransplant dialysis status into no dialysis before SLKT (preemptive kidney transplant) and any dialysis before SLKT (nonpreemptive). Baseline characteristics and outcomes were compared.ResultsBetween 1989 and 2017, inclusive, 84 SLKT procedures were performed in Australia, of which 24% were preemptive. Preemptive and nonpreemptive SLKT recipients did not significantly differ in age (P = .267), sex (P = .526), or ethnicity (P = .870). Over a median follow-up time of 4.5 years, preemptively transplanted patients had a statistically equivalent risk of kidney graft failure (hazard ratio (HR) 1.83, 95% confidence interval [CI]: 0.36-12.86, P = .474) and all-cause mortality (HR 1.69, 95% CI: 0.51-5.6, P = .226) compared to nonpreemptive patients. Overall, 1- and 5-year survival rates for all SLKTs were 92% (95% CI: 86-96) and 60% (95% CI: 45-75), respectively.ConclusionKidney graft and overall patient survival were similar between patients with preemptive kidney transplant and those who were dialysis dependent. 相似文献
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Marks J. H. Salem J. F. Adams P. Sun T. Kunkel E. Schoonyoung H. Agarwal S. 《Techniques in coloproctology》2021,25(6):721-726
Techniques in Coloproctology - The technical difficulty and steep learning curve of transanal total mesorectal excision (taTME) has limited widespread adoption. The single-port (SP) daVinci robot... 相似文献
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Kabundula Pelekelo P. Mbewe Esau G. Mwanza-Kabaghe Sylvia Birbeck Gretchen L. Mweemba Milimo Wang Bo Menon J. Anitha Bearden David R. Adams Heather R. 《AIDS and behavior》2022,26(10):3450-3450
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Shaked Lev-Ari MD Michael Serzan MD Tianmin Wu MS Andrew Ip MD Lauren Pascual HSD Brittany Sinclaire MS Shari Adams HSD Michael Marafelias BS Lakshmi Ayyagari MD Sarvarinder K. Gill MD Barbara Ma MD Jacob P. Zaemes MD Alexandra Della Pia PharmD Adil Alaoui MS Subha Madhavan PhD Anas Belouali MS Andrew Pecora MD Jaeil Ahn PhD Michael B. Atkins MD Neil J. Shah MD 《Cancer》2023,129(12):1885-1894
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Robinson Sandra M. Scott Jason Ryan Sarah Adams Nicola Hassell Andrew Walker David 《Clinical rheumatology》2022,41(12):3869-3877
Clinical Rheumatology - Educating patients about methotrexate is a core role of rheumatology nurses. We have previously reported the scoring of videoed interviews of rheumatology nurses educating... 相似文献
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Holder-Dixon Amani R. Adams Olivia R. Cobb Tianna L. Goldberg Alison J. Fikslin Rachel A. Reinka Mora A. Gesselman Amanda N. Price Devon M. 《Journal of behavioral medicine》2022,45(5):760-770
Journal of Behavioral Medicine - Medical avoidance is common among U.S. adults, and may be emphasized among members of marginalized communities due to discrimination concerns. In the current study,... 相似文献
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Amanda M. Nelson Zhaoyuan Cong Samantha L. Gettle Amy L. Longenecker Michal Kidacki Joslyn S. Kirby David R. Adams Douglas B. Stairs Frederick W. Danby 《Experimental dermatology》2019,28(7):867-871
Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease affecting the pilosebaceous units in the axilla, groin and buttocks. While the pathogenesis of HS is not clear, mechanical stress exacerbates HS. In this study, we aimed to determine whether intracellular adhesive junctions may be aberrant in HS patient skin. Strikingly, we observed loss of E‐cadherin and p120ctn protein expression, two key adherens junction proteins, in ~85% of HS severe skin lesions. Moreover, loss of protein expression was apparent in non‐lesional skin from HS patients and the degree of loss positively correlated with HS Hurley Stage of disease. E‐cadherin expression was unaltered in other inflammatory skin conditions including chronic wound epithelium, atopic dermatitis, and acne vulgaris compared with healthy skin suggesting that its loss may be uniquely relevant to HS pathogenesis. A complete loss of α‐catenin, β‐catenin and ZO‐1 was not observed; however, some cytoplasmic staining of the catenins was noted in HS epithelium. We also demonstrated diminished desmosome size in HS lesional skin. Overall, our data suggested that loss of adherens junction proteins and diminished desmosome size in HS skin contributes to the skin's inability to withstand mechanical stress and provides rationale as to why mechanical stress exacerbates HS symptoms. 相似文献