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Objectives To investigate the prevalence of sinonasal lymphoepithelial carcinoma (SNLEC) in Guangzhou, a high incidence area of nasopharyngeal carcinoma (NPC), and to dete ct whether it is associated with Epstein-Barr virus (EBV) infection. Methods Twenty confirmed SNLEC specimens were collected from all of the sinonasal carcin oma biopsies performed in the 8 years 1989-1996 at the Sun Yat-sen University o f Medical Sciences. EBV encoded early RNAs were detected by use of in-situ hyb ridization. A variety of antigens, including the EBV nuclear antigen 1, latent membrane protein 1, BZLF1 protein, diffuse early antigen, viral capsid antigen a nd membrane antigen, were detected using immunohistochemistry. Additionally, 36 NPC specimens were used for comparison. Results Twenty SNLECs were identified. Seventeen SNLECs were developed in the nasal cav ity, and 3 in the maxillary sinus. The mean age (46.25 y), male to female ratio (3∶1), histopathology and lymphoinfiltration of the 20 SNLECs were id entical with those of the 36 NPCs. Thirteen (65.0%) of the 20 SNLECs showed an expansive growth pattern, while 27 (75.0%) of the 36 NPCs showed an infiltrat ing or mixed growth pattern. The majority of cancer cells in all of the 20 SNLE Cs showed EBV encoded early RNAs. The EBV nuclear antigen 1 expression of SNLEC was less intensive than that of NPC. The expression rate of latent membrane pr otein 1 for SNLEC (3/20,15%) was lower than that for NPC (19/36, 52.8%). The e xpression rates of BZLF1 protein (2/20, 10.0%), diffuse early antigen (19/20, 9 5.0%), viral capsid antigen (15/20, 75.0%), and membrane antigen (13/20, 65.0 %) for SNLEC were higher than those (0/36, 0.0%; 31/36, 86.0%; 18/36, 50%; and 14/36, 38.9%) for NPC. Conclusions SNLEC is not uncommon in Guangzhou. This tumour is also consistently associated with EBV infection like NPC. As compared to NPC, the EBV harbored in SNLECs s eems to express the EBV nuclear antigen 1 weakly and has a lower expression rate of latent membrane protein 1 as well as higher expression rates of EBV lytic pr oducts. 相似文献
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Na_2CaEDTA(乙烯二胺四乙酸二钠钙)(1,2,3,4),维生素 C(5)和芸香背(6)对铅中毒均有一定疗效。我们曾治疗铅中毒患者73例,其中利用 Na_2C_3 EDTA 治疗背20例,用 Na_2CaEDTA合。合并维生素 C 及芸香苷治疗者20例,用维生素 C 治疗者15例,用维生素 C 合并芸香苷治疗者18例。本文报告上述各种疗法的效果。 相似文献
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