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目的:为了寻求墒单、敏感、无创性诊断伴有室上速发作史的隐匿性预激综合征方法。方法:应用高分辨心电图仪对18例正在发作的QRS波不增宽型室上速患者进行心电信号平均、滤波处理。与心内电生理检查诊断结果相比较。结果:发现隐匿性旁道引起的室上速心电信号叠加滤波图与房室结双径路引起的室上速心电信号叠加滤波图表现明显不同。前者,在心电信号叠加滤波图上,于V波后可清晰见到A波,且VA>AV,VA间期>110毫秒;后者,在心电信号叠加滤波图上,A波大多隐藏在V波内或与V波重叠,少数在V波后清晰可见,但VA间期<110毫秒。二者比较具有明显的统计学意义。结论:高分辨心电图可以方便、有效、无创性诊断伴有室上速发作史的隐匿性预激综合征。 相似文献
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凝血因子Ⅶ及其基因MspI多态性与心肌梗塞危险性的研究 总被引:5,自引:0,他引:5
目的;探讨凝血因子Ⅶ活性及其基因MspI多态性与中国汉族人心肌梗塞的关系。 方法:测定125例健康人(正常对照组)和137例心肌梗塞患者(心肌梗塞组)血浆凝血因子Ⅶ活性;采用聚合酶链反应(PCR)和MspI酶切法确定其基因型。 结果:①心肌梗塞组血浆凝血因子Ⅶ活性(P<0.01)和血清总胆固醇(P<0.05)均显著高于正常对照组;仅前者与心肌梗塞的危险性独立相关(OR=1.04,P<0.01)。②凝血因子Ⅶ基因型和等位基因的频率分布在两组间无显著差异。③M_1M_1纯合子血浆凝血因子W活性显著高于M_1M_2杂合子(P<0.05)。 结论:支持血浆凝血因子Ⅶ活性升高是中国汉族人心肌梗塞的危险因素;凝血因子Ⅶ活性受其基因MspI多态性的影响,但该多态性并不是中国汉族人心肌梗塞的独立危险因子。 相似文献
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中国资寿尼群地平和德国拜尔——尼群地平药代、药效学交叉比较研究 总被引:1,自引:0,他引:1
目的:比较Syst-China和Syst-Eur的一线药物中国资寿尼群地平和德国拜尔尼群地平的药代动力学、药效学、副作用的异同.方法:用随机、交叉比较方法,分别给8个男性健康志愿者口服40mg资寿尼群地平或拜尔尼群地平,采用高效液相紫外荧光检测法测定服药前及服药后不同时点血清中尼群地平的浓度.结果:8个健康志愿者服用上述药物后,各时点测定的平均血药浓度在两种药物之间无明显差别;其药代动力学参数AUC、Cmax、Tmax均无明显差别,两药的AUC之比为0.996;两药对收缩压影响不大,对舒张压降低明显,降压幅度及反射性心率增快作用相似,最大降压幅度分别为37、3%和47.6%.结论:中国资寿尼群地平和德国拜尔尼群地平是“生物等效”的,因此分别用上述两种药物作为一线药物的大规模临床试验Syst-China和Syst-Eur得出的结果是可比的. 相似文献
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Association of coagulation factor Ⅶ with the risk of myocardial infarction in the Chinese 总被引:5,自引:0,他引:5
Objective To elucidate the association of plasma factor Ⅶ coagulant activity (FⅦc) w it h the risk of myocardial infarction (MI) and to assess the influence of factor Ⅶ gene MspI polymorphism and lipid metabolism on FⅦc in the Chinese.Methods A total of 137 patients with angiographically confirmed MI and 125 healthy indiv iduals were evaluated retrospectively. Plasma FⅦc was measured by one-sta ge prothrombin time, and FⅦ genotype was determined after MspI digestion of polym erase chain reaction-amplified genomic DNA. Serum lipid levels were assessed b y routine methods.Results MI patients had significantly higher levels of FⅦc (119.5%±22.7% vs 99. 9% ±21.8%, P<0.01) and total serum cholesterol (5.80±1.06 mmol/L vs 5.5 3±1.08 mmol/L, P<0.05) than controls, but only FⅦc independently co rrelated with the risk of MI (OR=1.04, P<0.01). There were no significant di fferences in FⅦ genotype or allele frequency between patients and controls ( P>0.05). Subjects with the Gln353 allele were associated with significantly lower FⅦc levels than Arg353 homozygotes (99.7%±19.3% vs 111.4%±24.6% , P<0.05). Serum triglyceride was positively correlated with plasma FⅦc in both control (r=0.25, P<0.01) and case (r=0.87, P<0.01) gro ups, but this correlation was restricted to Arg/Arg genotype (r=0.68, P <0.01). A significant correlation of total serum cholesterol with FⅦc onl y appeared in Arg/Arg homozygotes (r=0.17, P<0.01).Conclusions Our findings support the role of plasma FⅦc as a risk factor for MI in Chin es e. Plasma triglyceride and FⅦ gene MspI polymorphism are two independent d eter minants of FⅦc. Assay of this polymorphism will be helpful in determining who will benefit most from lipid-lowing therapy. 相似文献
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