肾部分切除术后肾功能评估方法研究

肾细胞癌（renal cell carcinoma, RCC）是一种常见的泌尿系恶性肿瘤，随着早期肾细胞癌诊断率的不断提升，保留肾单位手术（nephron-sparing surgery, NSS）成为治疗T₁期和部分T₂期肾细胞癌的金标准，以肾部分切除术（partial nephrectomy, PN）应用广泛，但是该手术方式以及术后并发症存在一定的风险，因此术后评估肾功能对于评价手术安全性以及预测患者预后至关重要。本文介绍了近年来PN术后肾功能评估方法的研究进展。     

恶性纤维组织细胞瘤的诊治体会(附7例报告)

目的 总结7例恶性纤维组织细胞瘤的临床病理特点、治疗方法和预后.方法 回顾性分析7例恶性纤维组织细胞瘤患者的临床和病理资料,并结合国内外文献进行分析.结果 7例患者表现为进行性消瘦、肿块、疼痛,术后免疫组化证实为恶性纤维组织细胞瘤.行根治性手术切除后,未见复发.4例患者术后死于肺转移,3例患者无瘤存活至今.结论 恶性纤维组织细胞瘤术前诊断困难,免疫组化技术有助于确诊.早发现、早期行根治性手术是提高治愈率、减少复发和延长生存时间的关键.     

甲氧基聚乙二醇体外修饰移植物细胞对单倍体相合小鼠造血干细胞移植后GVHD的影响

本研究探讨甲氧基聚乙二醇(mPEG)化学修饰移植物细胞对小鼠单倍体相合干细胞移植后移植物抗宿主病(GVHD)的影响.取经mPEG修饰及未修饰的成年CB6小鼠脾细胞悬液注入BALB/c新生幼鼠的腹腔(5×106脾细胞/只),以脾增大指标判断新生BALB/c小鼠注射单倍体相合供鼠脾细胞后的GVHD反应;取经mPEG修饰及未修饰的成年BALB/c小鼠骨髓及脾细胞混合悬液(BMS)尾静脉注入接受致死量γ射线照射后的成年BALB/c小鼠(2×105个BMS/只),注射后第8天取受鼠脾脏,计数脾结节数.结果表明修饰组脾指数1(SI1)较未修饰组减低,修饰组脾指数2(SI2)值＜1.3,未修饰组SI2值＞1.3,提示接受mPEG修饰的单倍体相合脾细胞输注后,修饰组GVHD程度较未修饰组轻;未修饰组与修饰组相比较,脾结节形成的数量差异无显著性意义(p＞0.05),说明mPEG修饰不影响造血干祖细胞的活性.结论mPEG修饰移植物可减轻小鼠单倍体相合干细胞移植后的GVHD,而不影响干祖细胞活性.     

医院药库管理工作的探讨

研究医院药库规范化管理体系。我院通过制定完善的规章制度,提高药库工作人员的素质,规范药品的采购、验收、保管及供应等流程,保证了药品的质量安全,实现药库的规范化管理。     

冠心宁片联合尼可地尔对急性心肌梗死经皮冠状动脉介入术后患者心脏功能、血管内皮功能及血液流变学的影响

<正>本研究旨在观察冠心宁片联合尼可地尔治疗急性心肌梗死（AMI）行经皮冠状动脉介入治疗（PCI）术后心血瘀阻证患者的临床效果，及对心功能、冠脉微循环、血管内皮功能及血液流变学的影响，结果报道如下。1资料与方法1.1一般资料：选取2018年1月到2021年9月在建德市第二人民医院和杭州市第一人民医院行PCI术后“胸痹、心痛”心血瘀阻证的AMI患者80例，分别采用随机数字表法分为两组：对照组40例，     

含铁血黄素纤维组织细胞瘤一例

<正>临床资料患者,男,27岁。因右下肢屈侧棕褐色丘疹4年,来我院就诊。患者4年前于右下肢屈侧发现一黄豆大棕褐色丘疹,边缘微红,表面光滑,界清,质硬,自诉捏之稍有痛感,否认其他自觉症状,无出血、破溃等现象,否认发病前局部外伤史及蚊虫叮咬史,未予治疗。其后患者自觉皮损渐增大,色加深,为求明确诊断,遂至我院就诊。患者自发病以来,饮     

Impact of intervened hypertension,hyperlipemia,hyperviscosity syndrome in incidence of cardiovascular and cerebrovascular diseases

Background：AccordingtoAmericanHeartAssociation＇sre－port，deathcompositionofcerebrovascularandcerebrovasculardis－easewasincreasedto２９％in１９９６，andnow３３％from２５％in１９９２．Now，atherosclerosisseriouslyendangerhuman＇shealth．Hypertension，hyperlipemiaandhyperviscositysyndromearemainriskfactorsofcardiovascularandcerebrovasculardis－eases．Thereconditionsoftenexistedsimultaneouslyinel－ders．Interventiontothesediseasescanpreventcardiovascularandcerebrovascularevents，whichisfeasi…     

干预高血压、高血脂、高黏滞血症对心脑血管疾患发生率的影响

Background:According to American Heart Association's report,death composition of cerebrovascular and cerebrovascular disease was increased to 29％ in 1996,and now 33％ from 25％ in 1992.Now,atherosclerosis seriously endanger human's health.Hypertension,hyperlipemia and hyperviscosity syndrome are main risk factors of cardiovascular and cerebrovascular diseases.There conditions often existed simultaneously in elders.Intervention to these diseases can prevent cardiovascular and cerebrovascular events,which is feasible. Objective:To investigate impact of hypertension,hyperlipemia and hyperviscosity syndrome on incidence of cardiovascular and cereborvascular events. Design:Random,controlled study. Unit:Department of Senile Diseases, Qianfoshan Hospital of Shandong. Subjects:In study group, 52 senile subjects with complete hospitalizing data were recruited from 1995～ 2000.Patients with hypertension,hyperlipemia ,hyperviscosity syndrome were included in the current study.13 subjects asked medical help due to hypertension,25 due to hyperlipemia and 14 due to hyperviscosity syndrome.Sometimes blood pressure of hypertension patients was 140～ 160/90～ 100 mmHg.Patients' mean age was 65.21.Ratio of male to female was 13:1.In control group,50 outpatients were included who had similar diseases those in study group.Mean age was 62.34 and ratio of male to female was 17.33:1. Intervention:In study group,calcium antagonist such as adalatcc, nitrendipine, plendil and/or ASCE inhibitor such as perindopril and captopril were given o.s.Blood pressure was con trolled to normal level.Blood lipid regulating drugs such as pravastatin, ticlopidine,and lipanthy were given for hyperlipemia patients.For patients with hyperviscosity syndrome,enteral aspirin or persantine was given,50～ 75 mg/day.Interval of drugs was 1 day to 2 months.Detailed data was unavailable.Red sage root or its compound form injecto was given i.v.,70 mg/day,pueraria root was given i.v.300～ 500 mg/day;astraglaus root was given 20～ 214 g/day,ginkgo leaf,70 mg/day.10～ 15 days was a disease course.Drugs were given for once in 17 subjects and twice 35 subjects.No subjects received 3 times of therapy.In control group,patients received no described treatment during 5 years.Outpatients' medical records as well as discharge record for inpatients were read to study conditions during five 5 years retrospectively. Main prognosis indexes:Collection point for statistical analysis was determined as begging phase of obervation and end point after 5 years.Cardiovascular events such as heart infarction,cerebrovascular disease such as cerebral infarction,cerebral hemorrhage and TIA were evaluated. Result: Incidence of cardiovascular and cerebrovascular events was markedly lower in study group compared with that in control group.In study group,2 subjects developed acute heart infarction(3.84％ ),11 subejcts developed heart infarction in control group(22.00％ )(P< 0.01).Ischemic cerebrovascular disease occurred in 1 subject(1.92％ ) in study group and 7 in control group(14.00％ ).Amount of cerebral hemorrhage showed no significant decrease in 1 subject (1.92％ )in study group and 3 subjects in control group(6.00％ )(P >0.05). Conclusion:Risk factors of cardiovascular and cerebrovascular disease in elders should be actively intervened to reduce development of cardiovascular and cerebrovascular disease.     

功能性消化不良患者心理状态的调查分析

功能性消化不良(functional dyspepsia,FD)是指具有上腹痛、上腹胀、早饱、嗳气、食欲不振、恶心、呕吐等上腹不适症状,经检查排除引起这些症状的器质性疾病的一组临床综合征,症状可持续或反复发作,病程一般规定为超过1个月[1],是消化科的常见病.国外文献报道FD患病率为20%～40%[2]. 目前FD的发病机制尚未明确,但精神紧张和心理异常是重要成因为许多学者所共识[3].这部分患者在消化科门诊中占相当比例,尤其合并心理异常者认为症状严重和难以治疗而频繁就诊,这不仅影响患者生活质量,而且构成了相当高的医疗费用.我们对91例以消化道症状或失眠为主诉而被诊断为FD的患者进行心理测验,探讨FD患者焦虑、抑郁等不良心理状态,为临床治疗及有针对性的护理干预提供理论依据,从而提高患者的生活质量.