综合性心理护理缓解未婚初次人工流产者负性情绪及术后疼痛效果观察

目的探究综合性心理护理缓解未婚初次人工流产者负性情绪及术后疼痛的临床效果。方法选取于2017年6月至2017年12月我院收治的未婚初次人工流产患者120例,按照随机分组的方式分为对照组和实验组,每组各60例,对照组患者采用常规护理模式,实验组患者在常规护理的基础上接受综合性心理护理,观察两组患者负性情绪和术后疼痛的缓解效果。结果观察组患者的SAS评分为(29.02±3.05)分,SDS评分为(26.30±2.12)分,显著低于对照组患者的SAS评分(38.68±4.72)分和SDS评分(35.29±3.29)分,差异具有统计学意义(P0.05)。两组患者术后疼痛程度均呈下降趋势,但观察组患者的术后1h和4h的疼痛程度轻于对照组,差异具有统计学意义(P0.05)。结论综合性心理护理可以有效缓解未婚初次人工流产患者的负性情绪,并且降低患者术后的疼痛程度,具有重要临床意义。     

29例合并日本血吸虫病大肠癌的探讨

筑后川流域(久留米·乌栖地区),即山梨县甲府盆地,广岛县片山地方一带,自古以来就是日本血吸虫(以下简称日虫)三大流行区之一。日虫病有时合并癌肿,尤其是虫卵易寄生的肝脏,大肠部合并癌肿的报告较多,其两者的因果关系虽经各家学者进行种种研究,但至今还无明确的结论。最近,我们收集了合并日虫病的大肠癌29例,在论述研究结果的同时对有关日虫病与致癌的若干问题进行了探讨。     

米托蒽醌的急性毒性研究

Acute toxicity of mitoxantrone (DHAQ) synthetized by Department of Organic Chemistry, School of Pharmacy, WCUMS was studied in mice and dogs. The toxic effects were compared with those of adriamycin (ADR). The LD50 were 6.6 +/- 1.3 and 7.1 +/- 1.6 mg/kg DHAQ, 7.9 +/- 2.1 and 10.7 +/- 2.2 mg/kg ADR (P = 0.95) respectively on observation with a single dose i.v. and i.p., for 21 days in Kunming mice. The toxicity appeared to be delayed with DHAQ and ADR. The earliest death occurred on 4th day after treatment in mice. In the third week still a few died. There were obvious decreases in WBC counts in the peripheral blood of mice receiving either 1-2.5 mg/kg DHAQ or 2.5-5 mg/kg ADR with a single dose i.p.. The WBC count could return to normality after 3 weeks with the withdrawal of the drugs. On electron microscopic examination of myocardial samples from mice 4 days after a single dose of 20 mg/kg DHAQ i.p., mitochondria swelling and vacuoles formation in some cells were shown. Besides the above-mentioned changes, some myocytes exhibited disorientation and loss of myofilaments in the mice which received equivalent dose of ADR. In dogs anaesthetized a temporary falling of blood pressure and slowing of heart rate were observed following 5-10 mg/kg DHAQ i.p.. When a dose of 50-100 mg/kg was given, the blood pressure dropped continuously until death.     

光镜和电镜下肠癌与血吸虫病肠的改变及其关系的探讨

作者用光镜和电镜对50例肠标本进行观察。结果血吸虫病、肠炎与正常的肠上皮细胞结构类同;肠癌和肠癌合并血吸虫病的癌细胞特征无大的差异;邻近和远离癌组织的,以及有大量虫卵存积处的肠上皮细胞均正常,肠炎、肠血吸虫病、肠癌及合并癌均见到粘膜肌变性,以合并癌的例数多而重,及纤维母细胞增多,核畸变明显。以上改变是一些非特异性改变。血吸虫病,特别是虫卵与肠癌无直接因果关系,多系虫卵与肠癌并存。     

马桑内酯癫痫大鼠海马的形态计量研究

用１０只健康成年ＳＤ大鼠，５只实验鼠在左侧大脑皮质前肢运动区注射ＣＬ３．８μｌ诱发癫痫；５只对照鼠注射等量生理盐水、无癫痫发作。在癫痫鼠发作６０分钟后与对照鼠同时取脑，比较海马的结构。发现癫痫鼠海马ＣＡ１区锥体细胞粗面内质网、溶酶体和线粒体的面积分数显著增加，表明癫痫发作６０分钟，海马ＣＡ１区锥体细胞已发生了某些超微结构改变，这为进一步研究癫痫脑神经元损伤的可复性打下了基础。     

光镜和电镜下肠癌与血吸虫病肠的改变及其关系的探讨

The light and electron microscopic observations were carried out in 50 cases of colon specimens. No remarkable morphologic differences were found between the epithelial cells of the mucosa with schistosomiasis, colitis and the normal specimens. Cells of the colon carcinoma also showed no significant difference from those of the colon carcinoma associated with schistosomiasis. Atypical changes in the epithelial cells were not seen in the areas both adjacent to and remote from the carcinoma and in the egg deposit areas. Under LM, changes were manifested in various degrees in degeneration and disassociation of mucosal cells in colitis (1), schistosomiasis (1) and carcinoma associated with schistosomiasis (8). Under EM, changes in mucosal muscle cells were seen in colon carcinoma (2) and carcinoma associated with schistosomiasis (5). Proliferation of fibroblasts and hyperchromasia of the nuclei were noted in 3 cases of carcinoma associated with schistosomiasis. The pathological changes mentioned above were more prominent in cases of carcinoma associated with schistosomiasis than in those of colon carcinoma alone. The authors believed that the cause was non-specific changes induced by the toxin of the egg mechanical effects rather than a direct carcinogenic action of the eggs, and that the non-specific changes implied no direct relationship between the development of colon carcinoma and schistosomiasis.     

米托蒽醌的急性毒性研究

本研究结果表明,米托蒽醌对小鼠的LD_(50)与阿霉素相近,对外周血降白细胞作用强于阿霉素,心肌标本电镜观察显示损伤较阿霉素轻。对犬大剂量静脉推注可使其血压下降、心率减慢。     

肝脏同工铁蛋白性质的研究

本文研究了Wistar大鼠、正常人及肝细胞肝癌(HCC)病人的肝脏同工铁蛋白的性质。HCC病人的肝脏同工铁蛋白的铁与蛋白质比值为0.021,约为正常人的1/12。正常人及HCC病人的肝脏同工铁蛋白的分子量分别为20.5及21.5kd。鼠肝及HCC病人的肝脏同工铁蛋白的PAGE呈现一条区带,正常人肝为两条区带。正常人及Wistar大鼠肝脏及马脾同工铁蛋白的双向免疫扩散存在交叉反应。电镜观察到HCC病人肝脏同工铁蛋白颗粒疏松,大小不均。     

浅论民族民间医药在侗乡疟疾和流感预防中的应用

全国侗族人口约300万余人,大多居住在湘、桂、黔三省偏僻山区。这里山峦起伏,雨量充沛,气温潮湿,适合蚊虫病菌生长繁殖。因此,各种地方性传染病如疟疾、钩虫、丝虫、地甲病以及季节性传染病如流感、流脑、麻疹、白喉、百日咳、乙脑、钩体、痢疾等疾病时有流行。由于过去侗乡经济落后,交通不便,医疗卫生条件差,一旦疾病发生和流行,给侗乡人民生命财产带来巨大损失和灾难。因此,侗乡各族人民饱受疾病折磨,一般身体素质很差,贫血、消瘦,影响其生活、生产是不言而喻的。追溯历史,中医传入侗乡是上世纪20年代,西医传入侗乡是1940年(民国二十九年)…