排序方式: 共有75条查询结果,搜索用时 15 毫秒
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目的 探索高胆固醇饮食对阿尔茨海默病(AD)大鼠脑内白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)的影响.方法 海马齿状回注射β淀粉样蛋白(Ap)建立AD大鼠模型,根据饮食及注射试剂不同,分为高胆固醇+Aβ组、高胆固醇+磷酸盐缓冲液(PBS)组、标准饮食+Aβ组和标准饮食+PBS组;采用免疫组化和原位杂交检测海马齿状回、CA1区及皮质IL-6和TNF-α的水平.结果 海马齿状回和CA1区的IL-6和TNF-α阳性细胞数,高胆固醇+Aβ组分别为(44±5)个、(35±3)个和(35±6)个、(33±4)个,标准饮食+Aβ组分别为(29±3)个、(22±4)个和(28±4)个、(21±3)个,高胆固醇+PBS组分别为(18±3)个、(11±2)和(17±3)个、(14±4)个,标准饮食+PBS组分别为(11±3)个、(8±2)个和(13±2)个、(8±2)个,高胆固醇+Aβ组多于其他3组(P≤0.05).高胆固醇+Aβ组、高胆固醇+PBS组、标准饮食+Aβ组和标准饮食+PBS组皮质区IL-6阳性细胞数分别为(23±5)个、(20±3)个、(9±3)个和(11±3)个,TNF-α分别为(23±7)个、(21±6)个、(11±4)个和(10±4)个,高胆固醇组高于标准饮食组,IL-6、TNF-α水平仅与饮食有关,而与注射试剂无关.结论 高胆固醇饮食增加AD大鼠脑内重要炎症因子IL-6和TNF-α的表达,后者参与了神经变性. 相似文献
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目的 探讨中国大陆地区居民性别、吸烟、饮酒、高血压、糖尿病、血脂代谢异常等危险因素与颅内动脉粥样硬化性狭窄(intracranial atherosclerotic stenosis,ICAS)的关系.方法 系统检索中国生物医学文献数据库、中国期刊全文数据库、MEDLINE和EMBASE数据库.综合效应分析采用RevMan 5.0.23版本软件进行meta分析.经异质性检验后对性别、吸烟、饮酒、高血压、糖尿病进行OR值的合并;血脂代谢异常(TG、TC、HDL-C、LDL-C)进行MD值的合并;绘制漏斗图和计算失安全系数判断发表偏倚;敏感性分析检验meta分析结果稳定性.结果 最后9篇文献纳入meta分析,均为病例-对照研究,研究论证强度中等.性别(男性)、吸烟、饮酒、高血压、糖尿病对ICAS影响的合并OR(95%CI)值分别为1.00(0.82~1.23,P=0.99)、1.04(0.82~1.33,P=0.74)、0.91(0.69~1.20,P=0.51)、1.35(0.73~2.50,P=0.33)和1.71(1.04~2.81,P=0.03);TG、TC、HDL-C、LDL-C对ICAS影响的合并MD(95%CI)值分别为0.12(0.00~0.25,P=0.05)、0.06(-0.09~0.20,P=0.43)、-0.12(-0.23~-0.01,P=0.03)和0.24(0.14~0.33,P<0.001).结论 基于目前的研究,中国大陆地区居民糖尿病、LDL-C是ICAS的危险因素;HDL-C是ICAS的保护因素;尚无证据显示男性、吸烟、饮酒、高血压、TG、TC是ICAS的危险因素. 相似文献
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目的 研究电磁辐射孕鼠对仔鼠学习记忆和海马神经发生的影响.方法 将8只孕鼠随机分为对照组和辐射组,每组4只.辐射组以平均功率密度( 10::4) W/m2的900 MHz电磁波辐射孕鼠,从妊娠第1天到妊娠最后一天,每天辐射60 min;对照组不施加电磁波辐射.仔鼠出生后3周,利用Morris水迷宫检测仔鼠学习记忆功能,以5-溴脱氧尿嘧啶核苷检测海马齿状回神经发生.结果 900 MHz电磁辐射孕鼠会导致仔鼠学习记忆能力减退,辐射组逃避潜伏期(20.2±1.4)s高于对照组(11.0±2.4)8,而目标象限游泳距离百分比(35.3±3.2)%和穿环数(6.3±1.7)次/min均少于对照组(58.6±5.4)%和(14.5±2.2)次/min;辐射组仔鼠海马齿状回颗粒下层新生神经细胞数(96.7±23.4)个/视野少于时照组(156.5土28.1)个/视野;上述各指标2组比较,差异均有统计学意义(P<0.05或P<0.01).结论 孕期电磁辐射会抑制仔鼠海马神经发生,进而损害子代认知功能. 相似文献
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目的 观察动脉溶栓辅助血管内支架成形术治疗急性脑梗死的效果.方法 采用前瞻性病例对照设计,将24例动脉溶栓后遗留血管狭窄(>50%)的急性脑梗死患者分为支架治疗组和药物治疗组,分别给予支架成形术+药物治疗和常规药物治疗,评价两组血管完全再通率、残余狭窄率以及3个月时改良Rankin量表评分.结果 支架治疗组血管完全再通率高于药物治疗组(54.5%对0%,χ2=6.382,P<0.001),残余狭窄率显著低于药物治疗组(4.5%±5.2%对82.5%±10.5%,t=7.464,P<0.001),临床转归良好率显著高于药物治疗组(100%对76.9%,χ2=14.263,P=0.038).结论 动脉溶栓辅助血管内支架治疗急性脑梗死疗效优于药物治疗组,且较为安全.Abstract: Objective To investigate the efficacy of intra-arterial thrombolysis with stenting for acute cerebral infarction. Methods Using a prospective case-control design, 24 patients with acute cerebral infarction who remained angiostegnosis ( > 50%) after intra-arterial thrombolysis were randomly divided into stent treatment group and drug treatment group. They were treated with stenting + drug treatment and conventional drug treatment. The rates of vascular complete revascularization and residual stenosis, and the modified Rankin scale scores at 3 months in both groups were evaluated. Results The rate of complete revascularization in the stent treatment group was significantly higher than that in the drug treatment group (54. 5% vs.0%,χ2 =6.382, P <0. 001), and the rate of residual stenosis was significantly lower than that in the drug treatment group ([4.5 ±5.2]% vs. [82. 5 ±10. 5]%, t =7.464, P<0.001). The rate of favorable clinical outcome in the stent treatment group was significantly higher than that in the drug treatment group (100% vs. 76. 9%,χ2 = 14. 263, P = 0.038). Conclusion The efficacy of intra-arterial thrombolysis with stenting in the treatment of acute cerebral infarction is superior to that in the drug treatment group, and it is safer. 相似文献
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Objective To compare the safety and efficacy of intra-arterial urokinase thrombolysis alone and intra-arterial urokinase thrombolysis + stenting for ischemic stroke. Methods Sixty-four patients with acute cerebral infarction in the internal carotid artery system were analyzed retrospectively. The patients were divided into intra-arterial thrombolysis group (n = 38; using urokinase only) and stenting group (n = 26; using urokinase + stenting). The medical and imaging data of the patients in both groups were collected. The revascularization rate, and symptomatic intracranial hemorrhage and/or mortality rates were compared. The modified Rankin Scale (mRS) scores at 3 months were used to evaluate the clinical outcome in both groups. Results Of the 64 patients with ischemic stroke, 55 (85. 9%) had vascular occlusion, 9 (14. 0% ) had severe arterial stenosis. The revascularization rate in the thromborysis group was 47.4% (18/38), and that in the stenting group was 88.5% (23/26). Compared to the drug thrombolysis group, the proportion of patients whose mRS scores <2 at 3 months after procedure (47. 4% vs. 73. 1%,χ2 = 4. 18,P = 0. 00). There was no significant difference between the symptomatic intracranial hemorrhage rate and death rate (7. 8% vs. 7.7% , χ2 = 0.00, P =0. 62). Conclusions When patients with acute ischemic stroke are treated with ultra-early endovascular treatment, the revascularization rate of the occlusion and severe artery stenosis treated with mechanical recanalization + stenting was significantly higher than that of the simple intra-arterial thrombolytic drug, and the long-term clinical outcome is better. 相似文献
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目的 探讨颅内支架置入术后蛛网膜下腔出血(SAH)的发生及处理方法.方法 回顾性分析2007年1月至2008年5月本院开展颅内支架置入术后发生3例SAH的临床资料、发生特点、处理方法及临床转归.结果 颅内支架置入术后SAH的发生率为4.5%(3/66),3倒患者早期复查头颅CT未见出血增加,于24h后恢复抗凝、抗血小板治疗,3例患者出血分别于24h、3d和5d吸收,随访至今无明显异常.初步分析显示,SAH发生与血管狭窄率、支架释放前是否球囊扩张等明显相关.结论 颅内支架置入术后发生SAH机制复杂,及时有效的处理可获得满意的临床疗效.停用和恢复抗凝、抗血小板的最佳时间需要大样本、随机多中心的临床研究. 相似文献
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