Primary studies on heroin abuse and injury induced by oxidation and lipoperoxidation

Objective To further reveal serious risks of heroin abuse to human body and clarify grave injuries of oxidation, peroxidation and lipoperoxidation induced by nitric oxide and other free radicals to heroin abusers.Methods Determined and compared plasma levels of nitric oxide (P-NO), vitamin C (P-VC) , vitamin E (P-VE), β-carotene (P-β-CAR), lipoperoxides (P-LPO) a nd eryt hrocyte activities of superoxide dismutase (E-SOD), catalase (E-CAT), glutathi one peroxidase (E-GSH-Px) and erythrocyte level of lipoperoxides (E-LPO) in 1 37 cases of heroin abusers (HAs) and 100 cases of healthy volunteers (HVs), used linear regression and correlation, stepwise regression and correlation to analy ze correlation among heroin-abusing-duration (HAD), daily-heroin-abusing-qu antity (DHAQ) with above determination values in the HAs. Results Compared with the above average values in the HVs group, the average values of P -NO, P-LPO, E-LPO in the HAs group were significantly increased (P<0 .000 1), the average values of P-VC, P-VE, P-β-CAR, E-SOD, E-CAT and E-GS H-P x were significantly decreased (P<0.0001); the analysis of linear regressio n and correlation showed that with ascending of the HAD and DHAQ in the HAs, the values of P-NO, P-LPO, E-LPO were gradually increased (P<0.0001), t he values of P-VC, P-VE, P-β-CAR, E-SOD, E-CAT, E-GSH-Px were gradu ally dec reased (P<0.0001); the analysis of stepwise regression and correlation sugg ested that the correlation among the HAD, DHAQ with the values of P-NO, P-VC, P-VE was the closest.Conclusion The balance between oxidation and antioxidation in the HAs was seriously destroy ed, and the injuries induced by nitric oxide and other free radicals, oxidation, peroxidation and lipoperoxidation reactions to the body of HAs gravely exacerba ted. In the abstaining from heroin dependence, therefore, it should consider th at sufficient quantum antioxidants such as VC, VE and β-CAR are dosed to the H As so as to abate the injuries to their bodies.     

矽肺与NO、氧化及脂质过氧化关系的探讨

目的探讨矽肺与ＮＯ及氧化和脂质过氧化的关系。方法检测７３例矽肺患者和６０例健康对照者的血浆ＮＯ、ＶｉｔＣ、ＶｉｔＥ、β胡萝卜素（βＣＡＲ）、过氧化脂质（ＬＰＯ）含量及红细胞超氧化物歧化酶（ＳＯＤ）、过氧化氢酶（ＣＡＴ）、谷胱甘肽过氧化物酶（ＧＳＨＰｘ）活力和ＬＰＯ含量。结果与对照组比较,矽肺组的血浆ＶｉｔＣ、ＶｉｔＥ、βＣＡＲ含量及红细胞ＳＯＤ、ＣＡＴ、ＧＳＨＰｘ活力显著降低,血浆ＮＯ、ＬＰＯ含量及红细胞ＬＰＯ含量显著升高（Ｐ＜０．０５或Ｐ＜０．０１）;各检测值与病程均有相关;血浆ＮＯ、ＶｉｔＥ含量及红细胞ＳＯＤ活力、ＬＰＯ含量与病程相关最密切。结论矽肺患者体内的ＮＯ代谢异常,氧化和脂质过氧化反应病理性加剧。     

一氧化氮等自由基与慢性胆囊炎伴结石的关系

为探讨一氧化氮氧化、过氧化、脂质过氧化与慢性胆囊炎伴结石的关系 ,我们检测了 2 5例病人和 80例健康者血浆中一氧化氮 (Ｐ ＮＯ)、维生素Ｃ(Ｐ ＶＣ)、维生素Ｅ(Ｐ ＶＥ)、β 胡萝卜素 (Ｐ β ＣＡＲ)和过氧化脂质 (Ｐ ＬＰＯ)含量及红细胞超氧化物歧化酶 (Ｅ ＳＯＤ)、过氧化氢酶 (Ｅ ＣＡＴ)、谷胱甘肽过氧化物酶 (Ｅ ＧＳＨ Ｐｘ)活性和过氧化脂质 (Ｅ ＬＰＯ)含量并比较 ,同时 ,分析比较了胆囊结石病人手术前后上述检测值的变化。1.临床资料与方法 :( 1)治疗组 :抽检住院择期手术的慢性胆囊炎伴结石病人 2 5例 ,年龄 3 3～ 71( 5 3 …