首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  免费   2篇
综合类   2篇
  2012年   2篇
排序方式: 共有2条查询结果,搜索用时 0 毫秒
1
1.
Objective:To study the protective effect of an extract of Guipi Pill(归脾丸) against radiationinduced damage.Methods:A total of 100 Kunming mice were randomly divided into normal group,model group,positive drug group(treated with radioprotective agent "523",5 mg/kg at 24 h before irradiation) and two treatment groups,with 20 mice in each group.The extract of water extraction-alcohol precipitation (WAP) from Guipi Pill were administered orally to the mice in the two treatment groups at the dose of 500 and 1,000 mg/kg,respectively,for 6 days prior to whole body radiation(8 Gy).Fifty mice with 10 in each group were used to observe the survival rate 30 days after radiation.The other 50 mice with 10 in each group were sacrificed on day 10 after radiation(6 Gy) in order to take blood,liver and unilateral femur.Results:Pretreatment prior to irradiation with WAP resulted in a significantly higher 30-day survival rate of mice after exposure to a potentially lethal dose of 8-Gy radiation.WAP could significantly increase the total white blood cell count and DNA content of bone marrow,and it also increased the activity of various antioxidant enzymes,such as superoxide dismutase,catalase,total antioxidant capacity and glutathione peroxidase in liver tissue of mice, which were reduced by radiation treatment.Maleic dialdehyde level and bone marrow micronucleus rate were significantly reduced by WAP,which were increased after 6-Gy radiation.Conclusion:WAP of Guipi Pill could increase the 30-day survival rate and the antioxidant capacity as well as protect bone marrow in mice.WAP of Guipi Pill is an effective radioprotective agent.  相似文献   
2.
蒺藜全草中甾体皂苷类化学成分研究   总被引:13,自引:10,他引:3       下载免费PDF全文
[目的]对蒺藜全草化学成分进行研究。[方法]采用大孔吸附树脂柱色谱、硅胶柱色谱、ODS柱色谱及制备高效液相色谱法(PHPLC)对蒺藜70%乙醇提取液进行分离纯化,并利用理化数据测定和光谱数据分析等方法对所得单体进行了结构鉴定。[结果]分离鉴定了5个甾体皂苷:1)uttroside B;2)polianthoside D;3)替告皂苷元-3-O-β-D-吡喃木糖基-(1→2)-[β-D-吡喃木糖基-(1→3)]-β-D-吡喃葡糖基(1→4)-[α-L-鼠李糖基(1→2)]-β-D-吡喃半乳糖苷;4)(25R)-26-O-β-D-吡喃葡糖基-5α-呋甾-3β,22α,26-三醇-3-O-β-D-吡喃葡萄糖基(1→4)-吡喃半乳糖苷;5)海柯皂苷元-3-O-β-D-吡喃葡萄糖基-(1→2)-[β-D-吡喃木糖基-(1→3)]-β-D-吡喃葡萄糖基-(1→4)-β-D-吡喃半乳糖苷。[结论]化合物1和2为首次从蒺藜中分离获得。  相似文献   
1
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号