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1.
应力对骨折愈合的影响及其作用机制   总被引:31,自引:2,他引:29  
骨折愈合是一个高度复杂的再生过程,受到患年龄,力学环境,内分泌、局部血液供应等诸多因素的影响,其中应力是主要因素之一,应力刺激促进骨折愈合的机制仍不清楚,但有研究表明,骨组织对应力刺激有良好的适应性,骨细胞具有感受力学信号的功能,而第二信使cAMP,PGE2可能参与了信号传递,但其详细机制有待进一步的研究,生物力学的飞速发展,为骨折愈合的研究开拓了许多新思路和新领域,同时越来越认识到应力因素在骨折愈合中的重要作用。  相似文献
2.
Objective: To treat humerus fracture with three dimensional pattern and finite element analysis, providing mechanical basis for treating humerus fracture. Methods: Humerus pattern was established based on the CT images, and calculation was done by ANSYS5. 6 software. Three dimensional ten-node tetrahedron unit was selected and were divided into 2 729 nodes, 49 041 units. Distribution and amount of axial compression of humerus were analyzed when clip angle was 30°, 45°, 90° between fracture face and axial line with fixed X, Y, Z directions. Results: The distribution of stress was greatly different between fracture face and non fracture face. Stress in fracture part was fairly concentrated with incomplete symmetric distribution around the center of fracture face; Greater stress distributed in the regions 10 mm from fracture face, which was 2-3 times that of other stress regions. Conclusion: Required load must be estimated under various conditions as to select the suitable internal fixation implants dur  相似文献
3.
解剖型桡骨远端记忆聚合器的力学稳定性   总被引:6,自引:0,他引:6  
目的:探讨解剖型桡骨远端记忆聚合器(anatomic distal radius Ni-tinol memory connector,ADRMC)的力学稳定性。方法:20根尸体湿桡骨标本分别制作成远端横断型骨折模型,以ADRMC或普通钢板(CP)固定,采用万能材料试验机和静态电阻应变仪进行环抱支轴向环抱力的测试和三点弯曲、扭转实验。结果:ADRMC环抱支产生的最大轴向环抱力为12.82MPa;三点弯曲实验显示,ADRMC组和CP组板对侧加压分别为(3.92±1.22)和(5.26±2.37)N·m,板侧加压分别为(3.32±1.14)和(3.14±1.06)N·m,侧方加压分别为(4.27±2.13)和(3.96±1.34)N·m;当扭转角度大于2°时,CP组的屈服扭矩明显高于ADRMC组(P<0.05)。结论:ADRMC在提供牢靠固定的同时,轴向环抱持骨有利于稳定,纵向加压及记忆效应的存在可显著降低应力遮挡率。  相似文献
4.
碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)是体内重要的创伤愈合因子之一.骨折后bFGF通过调控骨组织中细胞增殖及分化、增加骨折局部骨密度及促进局部血管生成来加速骨折的愈合.此外,随着对bFGF研究的不断深入,其在骨组织工程所展现出的对骨修复的作用将越来越受到人们的重视.  相似文献
5.
骨折愈合中转化生长因子-β的作用机制   总被引:3,自引:0,他引:3  
转化生长因子β(TGF-β)是一族多肽生长因子,在骨生长,形态诱导及修复中占有非常重要的地位,虽然对骨形成,骨折愈合机制仍然存在许多疑问,但是细胞因子和多肽生长因子的作用却越来越明确。本文拟就TGF-β对骨形成的作用。调节以及TGF-β在骨折愈合中的效果作一综述。  相似文献
6.
髋臼三维有限元模型的建立   总被引:2,自引:0,他引:2  
目的:构建髋臼三维有限元模型.方法:选择成年湿髋臼尸体标本行CT扫描成像得到髋臼每层横截面图像,提取边界坐标,利用有限元分析软件ANSYS5.6构建髋臼三维有限元模型,三维十结点四面体实体单元进行网格划分.结果:所构建髋臼模型共划分为121 239个结点、112 491个单元,客观反映髋臼真实解剖形态及生物力学行为.结论:构建的髋臼三维有限元模型为髋臼骨折内固定的记忆力学研究提供可循模型.  相似文献
7.
艾灸联合手法治疗膝骨性关节炎临床疗效观察   总被引:2,自引:0,他引:2  
目的探讨艾灸联合手法治疗膝关节骨性关节炎的临床疗效。方法采用随机、前瞻性对照研究2007年1月至2008年6月,第二军医大学附属长海医院院收治的60例膝骨性关节炎的病例,对治疗疗效、疼痛、关节屈伸度、关节稳定度与上下楼梯分值进行评估。结果参照lysholm等的评估标准,治疗组优良率为93.3%,保守治疗组优良率73.30%,治疗组明显高于对照组(P〈0.05);两组疼痛、关节屈伸度、关节稳定度与上下楼梯分值进行比较,在疼痛与关节稳定度方面差异有统计学意义(P〈0.05)。结论艾灸配合手法治疗的中西医结合康复治疗方案能有效缓解患者的疼痛,改善关节稳定性,提高疗效。  相似文献
8.
Objective:To explore the mechanical behavior of acetabulum loaded by static stress and provide the mechanical basis for clinical analysis and judgement on acetabular mechanical distribution and effect of static stress. Methods:By means of computer simulation, acetabular three dimensional model was input into three dimensional finite element analysis software ANSYS7.0. The acetabular mechanical behavior was calculated and the main stress value, stress distribution and acetabular unit displacement in the direction of main stress were analyzed when anterior wall of acetabulum and acetabular crest were loaded by 1 000 N static stress. Results :When acetabular anterior wall loaded by X direction and Z direction composition force, the stress passed along 4 directions: (1)from acetabular anterior wall to pubic symphysis along superior branch of pubis firstly, (2)from acetabular anterior wall to cacroiliac joint along pelvic ring, (3)in the acetabulum, (4)from the suffered point to ischium. When acetabular crest loaded by X direction and Y direction composition force, the stress transmitted to 4 directions: (1)from acetabular crest to ilium firstly, (2)from suffered point to cacroiliac joint along pelvic ring, (3) in the acetabulum , (4)along the pubic branch, but no stress transmitted to the ischium branch. Conclusion:Analyzing the stress distribution of acetabulum and units displacement when static stress loaded can provide internal fixation point for acetabular fracture treatment and help understand the stress distribution of acetabulum.  相似文献
9.
镍钛-聚髌器在严重粉碎髌骨骨折治疗中的应用   总被引:1,自引:0,他引:1  
目的 探讨镍钛-聚髌器(NT-PC)治疗严重粉碎髌骨骨折的疗效及意义。方法 本组123例,均为严重粉碎骨折,经镍钛-聚髌器内固定。术后随访并对膝关节功能进行评判。结果 随访8-24个月,骨折愈合率100.0%。术后4-12周,平均7.4周膝关节伸、屈可达健侧水平。膝关节功能恢复评定优104例,良11例,可8例,临床优良率93.5%。结论 镍钛-聚髌器用于严重粉碎髌骨骨折的治疗,避免了髌骨部分或全部切除,最大限度保存膝关节功能,是目前一理想有效的治疗方法。  相似文献
10.
To study the memory biomechanical character of anatomic distal radius Nitinol memory connec-tor ( DRMC ) in treating distal radius fracture. Methods: Establishing three dimensional model and finite element anal-ysis, we calculated the stress in and around the fracture faces when distal radius fracture was fixated with DRMC. Re-suits: Axial holding stress produced by holding part of DRMC on distal radius was 14.66 MPa. The maximum stress of holding part was 40 - 70 MPa, the minimum stress was 3 - 7 MPa, and the stress of compression part was 20 - 40 MPa.Conclusion: The distribution of stress produced by DRMC around the fracture line is reasonable, and axial holding stress can help stabilize fracture during earlier period. The existence of longitudal compression and memory effect can transfer fixated disused section into developed section and enhance fracture healing.  相似文献
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