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1.
萘丁美酮的诱变性和致癌性研究   总被引:3,自引:0,他引:3  
为了探讨萘丁美酮的诱变性和致癌性,选用Ames试验(采用TA97、TA98、TA100、TA1024个标准菌株)、小鼠骨髓微核试验、体外培养的CHL细胞染色体畸变分析、小鼠睾丸生殖细胞染色体畸变分析和叙利亚地鼠胚胎细胞(SHE)转化试验进行了研究。结果所有试验均为阴性结果,未见萘丁美酮有诱变性和致癌性。  相似文献
2.
We conducted a series of toxicity tests and short-term mutagenic assays of Asulam and 40% (W/V) sodium Asulam. It was found that the LD50 of Asulam with acute oral toxicity was 30000 mg/kg for mice, and the LD50 of sodium Asulam for mice and rats were equal (8250 mg/kg). The cumulative coefficient of sodium Asulam in Wistar rats was 9.42. None died from sodium Asulam absorbed via skin. Negative results were obtained in Ames test, Bacillus subtilis repair test and the micronucleus test. There was no significant difference between the control group and the treated groups in the chromosomal aberration rates of spermatogonia and primary spermatocytes of mice testis. The results indicated that Asulam should be regarded as a substance of low toxicity and low accumulation. No mutagenicity was observed in our experiment.  相似文献
3.
SC1001A is a new sedative, hypnotic and anti-epileptic drug. Screening for possible mutagenicity of the agent consisted of a battery scheme of short-term mutagenic tests with different hereditary detecting end points. Three assays were with in the scheme: Ames test (for detecting gene mutation in vitro), micronucleus test (for detecting chromosomal aberration in vivo) and CHL (Chinese hamster lung cell line) test (for detecting chromosomal aberration in vitro). In addition, a routine teratogenicity study on SC1001A was carried out in mice. They were given daily at 3-dose levels (exposed to up to 33% of the LD50 by gastric incubation from the 6th through the 15th day of gestation. SC1001A gave uniformly negative results in all three mutagenic assay systems. Results of the teratogenic experiment showed that only the pregnant rate in bred mice in the moderate dose group and the mean maternal body weight gain of the dams during gestation in the low dose group were significantly lower than those in the corresponding control group. A clear dose-response relationship was not demonstrated. All dose levels of SC1001A used caused no adverse effects on the number of survival fetuses per litter, growth or development of the fetal mice. No malformations in the external appearance, of the internal organs and of the skeletal systems in fetal mice were observed. The above-mentioned results indicated that SC1001A induced neither gene mutation nor chromosomal damage both in vitro and in vivo. There was no evidence of teratogenesis. Therefore, it is estimated that SC1001A is probably comparatively safe as a pharmaceutical product for human beings in usual dosage.  相似文献
4.
为评价除草剂磺草灵的毒性,作者对磺草灵及其40%钠盐溶液进行了一系列一般毒性和一组短期诱变性试验。磺草灵的小鼠经口LD_(50) >30000mg/kg。磺草灵钠盐的大小鼠的经口LD_(50)均为8250mg/kg。磺草灵钠盐的大鼠蓄积系数为9.42。未见小鼠因磺草灵钠盐经皮吸收引起死亡。经Ames试验、枯草杆菌重组试验、小鼠骨髓微核试验及雄性小鼠睾丸精原细胞和初级精母细胞染色体畸变分析,均为阴性结果。以上结果表明:磺草灵是一种低毒、低蓄积性的物质,且未发现诱变性。  相似文献
5.
SC1001A是一种镇静、安眠及抗癫痫作用的合成新药。作者采用卫生部药检所近年按国际标准建立的药物致突变测试系列以及常规致畸胎试验,检测和评价了该种新药的毒性。结果表明:SC1001A属于低毒类化学物质;体内外测试系统均未发现其致突变性和/或潜在致癌性;也未观察到致畸胎性。  相似文献
6.
作者用诱发小鼠肺肿瘤短期试验证明氯丁二烯的致癌性。结果表明:吸入氯丁二烯2.9、19.2和189mg/m~3后,均可使小鼠肺肿瘤发生率增高;出现肺肿瘤多发性增加,并呈现良好的剂量反应关系。由于本研究所用最高浓度189mg/m~3在生产现场并非偶尔出现,故本研究结果提示了氯丁二烯的致癌性,并进一步支持本室关于氯丁二烯作业人员肿瘤流行病学调查的结果。  相似文献
7.
采用改进的Draize法对N-酰基谷氨酸的兔眼刺激反应进行评价,结果表明该物质具有刺激性,其眼刺激反应的强度及持续时间与接触时间长短有关。该物质20%浓度作用5分钟属强刺激,作用20秒种为中度刺激,故该物质不允许进入眼。作者还对眼刺激指标的优选、评价方法与标准、动物种属选择及影响因素等作了初步探讨。  相似文献
8.
作者应用小鼠骨髓多染红细胞微核试验和睾丸生殖细胞染色体畸变分析,研究了N-酰基谷氨酸的细胞遗传毒性。五天经口最高总剂量达2个LD_(50)时,微核率与阴性对照组无显著性差异。五天经口最高总剂量达1个LD_(50)时,睾丸生殖细胞染色体畸变分析结果仍为阴性。  相似文献
9.
癫痫是最常见的神经系统疾病之一。药物是目前治疗癫痫最常用和最重要的手段。以往的资料均表明,传统的抗癫痫药如丙戊酸钠、苯妥英钠、卡马西平等均有不同程度的胚胎发育毒性。患癫痫的孕妇服用后可致胎儿发育迟缓或畸形。九十年代以来,随着新一代抗癫痫药在临床上的应用。许多以往认为的难治性癫痫得到了较好的控制。使大部分孕龄期的癫痫妇女能够结婚生育。在这些新型抗癫痫药中,TPM以其多重的药理作用,在临床实践中表现出明显的治疗效果。  相似文献
10.
19世纪60年代以来,随着抗颠痫药(AEDS)在临床上广泛应用,使许多癫痫患者病情得到控制,但随之发现妊娠期间颠痫妇女新生儿出生畸形发生风险较正常人增高2至3倍。且胎儿生长迟缓的风险亦增加,因此认为,传统的AEDs均具有不同程度的胚胎发育毒性。九十年代以来,随着新一代抗癫痫药在临床上的应用,使许多以往认为难治性癫痫得到了较好的控制,尤其使大部分孕龄期患癫痫的妇女能够结婚生育。在这些新型抗癫痫药中TPM以其多重的药理作用,在临床实践中表现出明显的治疗效果。然而,妥泰是否适合妊娠期妇女服用,是否对胎儿的发育产生影响,  相似文献
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