全文获取类型
收费全文 | 31785篇 |
免费 | 2123篇 |
国内免费 | 31篇 |
专业分类
耳鼻咽喉 | 515篇 |
儿科学 | 1341篇 |
妇产科学 | 1086篇 |
基础医学 | 4443篇 |
口腔科学 | 1765篇 |
临床医学 | 3031篇 |
内科学 | 5500篇 |
皮肤病学 | 429篇 |
神经病学 | 2975篇 |
特种医学 | 1080篇 |
外科学 | 4452篇 |
综合类 | 154篇 |
一般理论 | 2篇 |
预防医学 | 2499篇 |
眼科学 | 536篇 |
药学 | 2201篇 |
中国医学 | 36篇 |
肿瘤学 | 1894篇 |
出版年
2021年 | 278篇 |
2020年 | 366篇 |
2019年 | 479篇 |
2018年 | 631篇 |
2017年 | 540篇 |
2016年 | 559篇 |
2015年 | 591篇 |
2014年 | 690篇 |
2013年 | 1200篇 |
2012年 | 1382篇 |
2011年 | 1396篇 |
2010年 | 859篇 |
2009年 | 893篇 |
2008年 | 1209篇 |
2007年 | 1361篇 |
2006年 | 1357篇 |
2005年 | 1383篇 |
2004年 | 1190篇 |
2003年 | 1159篇 |
2002年 | 1088篇 |
2001年 | 1059篇 |
2000年 | 1019篇 |
1999年 | 953篇 |
1998年 | 345篇 |
1997年 | 294篇 |
1996年 | 273篇 |
1995年 | 303篇 |
1994年 | 282篇 |
1993年 | 226篇 |
1992年 | 762篇 |
1991年 | 713篇 |
1990年 | 756篇 |
1989年 | 736篇 |
1988年 | 692篇 |
1987年 | 674篇 |
1986年 | 604篇 |
1985年 | 557篇 |
1984年 | 503篇 |
1983年 | 389篇 |
1982年 | 242篇 |
1981年 | 213篇 |
1979年 | 362篇 |
1978年 | 263篇 |
1977年 | 214篇 |
1976年 | 205篇 |
1975年 | 237篇 |
1974年 | 257篇 |
1973年 | 223篇 |
1972年 | 210篇 |
1971年 | 204篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Mahmut Gümüş MD Chieh-I Chen MPH Cristina Ivanescu PhD Saadettin Kilickap MD Igor Bondarenko MD Mustafa Özgüroğlu MD Miranda Gogishvili MD Haci M. Turk MD Irfan Cicin MD James Harnett PharmD Vera Mastey MS Ulrike Naumann MS Matthew Reaney MS Gerasimos Konidaris MS Medha Sasane PhD Keri J. S. Brady PhD Siyu Li PhD Giuseppe Gullo MD Petra Rietschel MD Ahmet Sezer MD 《Cancer》2023,129(1):118-129
2.
Straub Anton Vollmer Andreas Lâm Thiên-Trí Brands Roman C. Stapf Maximilian Scherf-Clavel Oliver Bittrich Max Fuchs Andreas Kübler Alexander C. Hartmann Stefan 《Clinical oral investigations》2022,26(12):7033-7044
Clinical Oral Investigations - Mechanisms of wound healing are often impaired in patients with osteonecrosis of the jaw (ONJ). According to the guidelines for the treatment of this disease, early... 相似文献
3.
4.
Abolhassani Hassan Vosughimotlagh Ahmad Asano Takaki Landegren Nils Boisson Bertrand Delavari Samaneh Bastard Paul Aranda-Guillén Maribel Wang Yating Zuo Fanglei Sardh Fabian Marcotte Harold Du Likun Zhang Shen-Ying Zhang Qian Rezaei Nima Kämpe Olle Casanova Jean-Laurent Hammarström Lennart Pan-Hammarström Qiang 《Journal of clinical immunology》2022,42(1):1-9
Journal of Clinical Immunology - Coronavirus disease 2019 (COVID-19) exhibits a wide spectrum of clinical manifestations, ranging from asymptomatic to critical conditions. Understanding the... 相似文献
5.
6.
Buket Bakan Fatih Oltulu Yeliz Y?ld?r?m Altu? Yava?o?lu Sinan Akg?l Nefise ülkü Karabay Yava?o?lu 《Arhiv za higijenu rada i toksikologiju》2023,74(3):207
The aim of this safety study in mice was to determine m>in vivo m> toxicity and biodistribution potential of a single and multiple doses of L-glutamic acid-g-p(HEMA) polymeric nanoparticles as a drug delivery system. The single dose did not cause any lethal effect, and its acute oral LD50 was >2.000 mg/kg body weight (bw). Multiple doses (25, 50, or 100 mg/kg bw) given over 28 days resulted in no significant differences in body and relative organ weights compared to control. These results are supported by biochemical and histological findings. Moreover, nanoparticle exposure did not result in statistically significant differences in micronucleus counts in bone marrow cells compared to control. Nanoparticle distribution was time-dependent, and they reached the organs and even bone marrow by hour 6, as established by m>ex vivo m> imaging with the IVIS® spectrum imaging system. In conclusion, L-glutamic acid-g-p(HEMA) polymeric nanoparticles appear biocompatible and have a potential use as a drug delivery system.KEY WORDS: biocompatibility, blood biochemistry, genotoxicity, histology, m>in vivo m> toxicity, micronucleus test, polymers 相似文献
7.
Abolhassani Hassan Landegren Nils Bastard Paul Materna Marie Modaresi Mohammadreza Du Likun Aranda-Guillén Maribel Sardh Fabian Zuo Fanglei Zhang Peng Marcotte Harold Marr Nico Khan Taushif Ata Manar Al-Ali Fatima Pescarmona Remi Belot Alexandre Béziat Vivien Zhang Qian Casanova Jean-Laurent Kämpe Olle Zhang Shen-Ying Hammarström Lennart Pan-Hammarström Qiang 《Journal of clinical immunology》2022,42(3):471-483
Journal of Clinical Immunology - Inborn errors of immunity (IEI) and autoantibodies to type I interferons (IFNs) underlie critical COVID-19 pneumonia in at least 15% of the patients, while the... 相似文献
8.
9.
Peter H. Egbers Anna-Liisa Sutt Jenny E. Petersson Liza Bergström Eva Sundman 《Acta anaesthesiologica Scandinavica》2023,67(10):1403-1413
Background
Weaning from mechanical ventilation and tracheostomy after prolonged intensive care consume enormous resources with optimal management not currently well described. Restoration of respiratory flow via the upper airway is essential and early cuff-deflation using a one-way valve (OWV) is recommended. However, extended OWV use may cause dry airways and thickened secretions which challenge the weaning process. High-flow therapy via the tracheostomy tube (HFT-T) humidifies inspired air and may be connected via an in-line OWV (HFT-T-OWV) alleviating these problems. We aim to provide clinical and experimental data on the safety of HFT-T-OWV along with a practical guide to facilitate clinical use during weaning from mechanical ventilation and tracheostomy.Methods
Data on adverse events of HFT-T-OWV were retrieved from a quality register for patients treated at an intensive care rehabilitation center between 2019 and 2022. Benchtop experiments were performed to measure maximum pressures and pressure support generated by HFT-T-OWV at 25–60 L/min flow using two different HFT-T adapters (interfaces). In simulated airway obstruction using a standard OWV (not in-line) maximum pressures were measured with oxygen delivered via the side port at 1–3 L/min.Results
Of 128 tracheostomized patients who underwent weaning attempts, 124 were treated with HFT-T-OWV. The therapy was well tolerated, and no adverse events related to the practice were detected. The main reason for not using HFT-T-OWV was partial upper airway obstruction using a OWV. Benchtop experiments demonstrated HFT-T-OWV maximum pressures <4 cmH2O and pressure support 0–0.6 cmH2O. In contrast, 1–3 L/min supplemental oxygen via a standard OWV caused pressures between 84 and 148 cmH2O during simulated airway obstruction.Conclusions
Current study clinical data and benchtop experiments indicate that HFT-T-OWV was well tolerated and appeared safe. Pressure support was low, but humidification may enable extended use of a OWV without dry airway mucosa and thickened secretions. Results suggest the treatment could offer advantages to standard OWV use, with or without supplementary oxygen, as well as to HFT-T without a OWV, for weaning from mechanical ventilation and tracheostomy. However, for definitive treatment recommendations, randomized clinical trials are needed. 相似文献10.