全文获取类型
收费全文 | 9494篇 |
免费 | 519篇 |
国内免费 | 122篇 |
专业分类
耳鼻咽喉 | 174篇 |
儿科学 | 206篇 |
妇产科学 | 99篇 |
基础医学 | 1698篇 |
口腔科学 | 172篇 |
临床医学 | 899篇 |
内科学 | 1818篇 |
皮肤病学 | 210篇 |
神经病学 | 548篇 |
特种医学 | 742篇 |
外科学 | 1145篇 |
综合类 | 37篇 |
一般理论 | 2篇 |
预防医学 | 337篇 |
眼科学 | 254篇 |
药学 | 907篇 |
中国医学 | 92篇 |
肿瘤学 | 795篇 |
出版年
2023年 | 46篇 |
2022年 | 39篇 |
2021年 | 302篇 |
2020年 | 181篇 |
2019年 | 210篇 |
2018年 | 283篇 |
2017年 | 216篇 |
2016年 | 266篇 |
2015年 | 419篇 |
2014年 | 535篇 |
2013年 | 563篇 |
2012年 | 793篇 |
2011年 | 772篇 |
2010年 | 481篇 |
2009年 | 413篇 |
2008年 | 548篇 |
2007年 | 595篇 |
2006年 | 518篇 |
2005年 | 449篇 |
2004年 | 324篇 |
2003年 | 305篇 |
2002年 | 239篇 |
2001年 | 212篇 |
2000年 | 208篇 |
1999年 | 183篇 |
1998年 | 98篇 |
1997年 | 103篇 |
1996年 | 102篇 |
1995年 | 65篇 |
1994年 | 57篇 |
1993年 | 70篇 |
1992年 | 51篇 |
1991年 | 40篇 |
1990年 | 45篇 |
1989年 | 61篇 |
1988年 | 56篇 |
1987年 | 52篇 |
1986年 | 45篇 |
1985年 | 43篇 |
1984年 | 12篇 |
1983年 | 16篇 |
1982年 | 17篇 |
1981年 | 12篇 |
1980年 | 13篇 |
1979年 | 9篇 |
1978年 | 10篇 |
1977年 | 17篇 |
1976年 | 13篇 |
1975年 | 9篇 |
1968年 | 4篇 |
排序方式: 共有10000条查询结果,搜索用时 20 毫秒
1.
Isolated patellofemoral arthritis is an increasingly recognized entity, and is usually associated with previous patellofemoral dysplasia or instability. Patellofemoral arthroplasty (PFA) has evolved significantly in recent years, both in terms of implant design and importantly in the understanding of appropriate patient selection. This review outlines the indications and investigations for PFA, provides a brief history of the development of contemporary implants, and presents the clinical outcomes for the prostheses most commonly used in the UK. In addition, it provides a detailed surgical technique for implantation of an onlay implant, with tips on how to optimize patellofemoral biomechanics and thus achieve a consistently good outcome. 相似文献
2.
Yoo Min Han Su Jin Chung Seokha Yoo Jong In Yang Ji Min Choi Jooyoung Lee Joo Sung Kim 《World journal of gastroenterology : WJG》2022,28(8):853-867
BACKGROUND Helicobacter pylori(H.pylori)infection is known to prevent the occurrence of gastroesophageal reflux disease(GERD)by inducing gastric mucosal atrophy.However,little is known about the relationship between atrophic gastritis(AG)and GERD.AIM To confirm the inverse correlation between AG and the occurrence and severity of GERD.METHODS Individuals receiving health checkups who underwent upper gastrointestinal endoscopy at Seoul National University Healthcare System Gangnam Center were included.The grade of reflux esophagitis was evaluated according to the Los Angeles classification.Endoscopic AG(EAG)was categorized into six grades.Serologic AG(SAG)was defined as pepsinogen I≤70 ng/m L and pepsinogen I/II ratio≤3.0.The association between the extent of EAG and SAG and the occurrence and severity of GERD was evaluated using multivariate logistic regression analysis.RESULTS In total,4684 individuals with GERD were compared with 21901 healthy controls.In multivariate logistic regression analysis,advanced age,male sex,body mass index>23 kg/m2,presence of metabolic syndrome,current smoking,and alcohol consumption were associated with an increased risk of GERD.Seropositivity for H.pylori immunoglobulin G antibodies was associated with a decreased risk of GERD.There was an inverse correlation between the extent of EAG and occurrence of GERD:Odds ratio(OR),1.01[95%confidence interval(CI):0.90-1.14]in C1,0.87(0.78-0.97)in C2,0.71(0.62-0.80)in C3,0.52(0.44-0.61)in O1,0.37(0.29-0.48)in O2,and 0.28(0.18-0.43)in O3.Additionally,the extent of EAG showed an inverse correlation with the severity of GERD.The presence of SAG was correlated with a reduced risk of GERD(OR=0.49,95%CI:0.28-0.87,P=0.014).CONCLUSION The extent of EAG and SAG exhibited strong inverse relationships with the occurrence and severity of GERD.AG followed by H.pylori infection may be independently protect against GERD. 相似文献
3.
4.
J. Yoo F. Shah S. Velangi G. Stewart J. S. Scarisbrick 《Clinical and experimental dermatology》2019,44(4):414-417
Secukinumab is an interleukin (IL)‐17 monoclonal antibody inhibiting T‐helper (Th)1‐mediated immune response. It has proven high efficacy for moderate to severe psoriasis but data on its long‐term toxicities are limited. We describe two patients who received secukinumab for clinically presumed psoriasis, but were subsequently diagnosed with mycosis fungoides (MF) following skin biopsies triggered by skin deterioration while on secukinumab. Previous studies suggested decreased numbers of regulatory T cells (Tregs) with increasing stage of MF, which may lead to the shift in the Treg/Th17 balance towards the Th17 pathway. Theoretically, the use of IL‐17 monoclonal antibodies to inhibit Th17 pathway may lead to further immunosuppression and disease progression in cutaneous T‐cell lymphoma (CTCL) by shifting the balance towards Tregs, although this hypothesis has not been proven. With uncertainty over the role of IL‐17 and Treg/Th17 as well as diagnostic challenges in CTCL, we recommend that patients should have a confirmatory skin biopsy prior to the commencement of biologic therapy. 相似文献
5.
Leyi Wang Saraswathi Lanka Debbie Cassout Nohra E. Mateus‐Pinilla Ganwu Li William C. Wilson Dongwan Yoo Paul Shelton Richard L. Fredrickson 《Transboundary and Emerging Diseases》2019,66(5):1809-1820
First described in 1955 in New Jersey, epizootic haemorrhagic disease (EHD) causes a severe clinical disease in wild and domestic ruminants worldwide. Epizootic haemorrhagic disease outbreaks occur in deer populations each year from summer to late autumn. The etiological agent is EHD virus (EHDV) which is a double‐stranded segmented icosahedral RNA virus. EHD virus utilizes point mutations and reassortment strategies to maintain viral fitness during infection. In 2018, EHDV serotype 2 was predominantly detected in deer in Illinois. Whole genome sequencing was conducted for two 2018 EHDV2 isolates (IL41747 and IL42218) and the sequence analyses indicated that IL42218 was a reassortant between different serotypes whereas IL41747 was a genetically stable strain. Our data suggest that multiple strains contribute to outbreaks each year. 相似文献
6.
Min Hee Hong MD Seong Gu Heo PhD Yun-Gyoo Lee MD PhD Hyo Song Kim MD PhD Keon Uk Park MD PhD Hoon-Gu Kim MD PhD Yoon Ho Ko MD PhD Ik-Joo Chung MD PhD Young Joo Min MD PhD Min Kyoung Kim MD PhD Kyu Ryung Kim PhD Jinseon Yoo MS Tae-Min Kim MD PhD Hye Ryun Kim MD PhD Byoung Chul Cho MD PhD 《Cancer》2020,126(20):4521-4531
7.
8.
Seungmo Lim Kil Hyun Kim Fumei Zhao Ran Hee Yoo Davaajargal Igori Su-Heon Lee Jae Sun Moon 《Archives of virology》2015,160(12):3153-3156
9.