全文获取类型
收费全文 | 7338篇 |
免费 | 387篇 |
国内免费 | 75篇 |
专业分类
耳鼻咽喉 | 28篇 |
儿科学 | 157篇 |
妇产科学 | 148篇 |
基础医学 | 1112篇 |
口腔科学 | 172篇 |
临床医学 | 416篇 |
内科学 | 1778篇 |
皮肤病学 | 257篇 |
神经病学 | 683篇 |
特种医学 | 261篇 |
外科学 | 1103篇 |
综合类 | 26篇 |
预防医学 | 189篇 |
眼科学 | 73篇 |
药学 | 520篇 |
中国医学 | 17篇 |
肿瘤学 | 860篇 |
出版年
2023年 | 28篇 |
2022年 | 32篇 |
2021年 | 147篇 |
2020年 | 78篇 |
2019年 | 112篇 |
2018年 | 157篇 |
2017年 | 164篇 |
2016年 | 175篇 |
2015年 | 175篇 |
2014年 | 248篇 |
2013年 | 294篇 |
2012年 | 479篇 |
2011年 | 533篇 |
2010年 | 311篇 |
2009年 | 250篇 |
2008年 | 437篇 |
2007年 | 516篇 |
2006年 | 497篇 |
2005年 | 497篇 |
2004年 | 486篇 |
2003年 | 519篇 |
2002年 | 485篇 |
2001年 | 77篇 |
2000年 | 63篇 |
1999年 | 94篇 |
1998年 | 110篇 |
1997年 | 70篇 |
1996年 | 66篇 |
1995年 | 77篇 |
1994年 | 67篇 |
1993年 | 54篇 |
1992年 | 50篇 |
1991年 | 51篇 |
1990年 | 50篇 |
1989年 | 49篇 |
1988年 | 29篇 |
1987年 | 30篇 |
1986年 | 22篇 |
1985年 | 23篇 |
1984年 | 19篇 |
1983年 | 16篇 |
1982年 | 27篇 |
1981年 | 12篇 |
1980年 | 15篇 |
1979年 | 17篇 |
1978年 | 11篇 |
1977年 | 8篇 |
1976年 | 10篇 |
1973年 | 11篇 |
1972年 | 8篇 |
排序方式: 共有7800条查询结果,搜索用时 218 毫秒
1.
Harada Hideyuki Omori Shota Mori Keita Konno Masahiro Murakami Haruyasu Imagumbai Toshiyuki Fukuda Haruyuki Nakamatsu Kiyoshi Kimura Tomoki Tanabe Hiroaki Fujita Hideki Tatebe Hitoshi Fujitaka Kazunori Nishimura Yasumasa 《International journal of clinical oncology / Japan Society of Clinical Oncology》2022,27(6):1025-1033
International Journal of Clinical Oncology - This multi-institutional clinical trial evaluated the feasibility of intensity-modulated radiotherapy (IMRT) for patients with locally advanced... 相似文献
2.
Azusa Ikeda Yoshihiro Watanabe Hikari Kaba Kimihiko Kaneko Toshiyuki Takahashi Saoko Takeshita 《Brain & development》2019,41(4):367-372
Background
Myelin oligodendrocyte glycoprotein antibodies (MOG Abs) are frequently detected in pediatric acquired demyelinating syndrome (ADS), and MOG-Ab-positive ADS differs from multiple sclerosis (MS) and aquaporin-4 (AQP4)-Ab-positive neuromyelitis optica spectrum disorder (NMOSD) in terms of age distribution, therapeutic response, and prognosis.Methods
Based on medical records, we retrospectively evaluated patients with MOG-Ab-positive NMOSD treated in the acute phase who were followed up in the chronic phase at our hospital from January 2011 to December 2017.Results
The patients comprised two boys and two girls aged 3–12 (median, 8) years. Peak MOG-Ab titers were 1:2048 to 1:32768 (median, 1:10240), and the relapse rate ranged from 0 to 1.25 times/year (median, 0.59 times/year); no sequelae were observed in any cases. Lesions other than those of optic neuritis were distributed at the cortex in one patient, subcortical white matter in four, deep white matter in three, and brainstem in one, all of which were disseminated lesions. No lesions were found in the corpus callosum, periventricular white matter, diencephalon, and regions adjacent to the third and fourth ventricles. The lesions tended to be asymptomatic, and two patients aged >5?years had well-demarcated lesions.Conclusion
All the patients showed disseminated lesions in the subcortical region to deep white matter, which were different from those found in MS and AQP4-Ab-positive NMOSD and were consistent with the characteristics of brain lesions in MOG-Ab-positive ADS, including other disease types. 相似文献3.
4.
5.
Takako Fujita Yukiko Ihara Hitomi Hayashi Atsushi Ishii Hiroshi Ideguchi Takahito Inoue Taichi Imaizumi Toshiyuki Yamamoto Shinichi Hirose 《Congenital anomalies》2020,60(6):189-193
Coffin-Siris syndrome (CSS) is a congenital anomaly syndrome characterized by developmental delay, coarse facial features, and hypoplasia of the fifth digit's nail or phalanges. Herein, we report a case of the 8-year-old female patient who showed developmental delay associated with dysplasia in the macular and large toe area. Comprehensive genomic analysis showed no possible candidate variants, but the subsequent genomic copy number analysis revealed a novel exonic deletion in the coding region of AT-rich interactive domain-containing protein 1B (ARID1B), a gene responsible for CSS. Genomic copy number analysis can aid in diagnosing CSS by confirming undiagnosed exonic deletions in ARID1B. Furthermore, this is the first report of CSS associated with bilateral macular dysplasia. 相似文献
6.
Taichi Imaizumi Keiko Yamamoto-Shimojima Hitoshi Yamamoto Toshiyuki Yamamoto 《Congenital anomalies》2020,60(1):10-14
Genomic copy number variations (CNVs) can be detected by chromosomal microarray testing. However, upon final diagnosis, other methods may be recommended for a validation method to confirm CNVs. Trio analyses or carrier detection in family members are also frequently required. Previously, fluorescence in situ hybridization and/or quantitative PCR have been used; however, these methods present limitations. The purpose of this study was to establish a simple and rapid method to detect genomic copy numbers. We utilized droplet digital PCR (dPCR) with an intercalation method. Thirteen patients, who were diagnosed with MECP2 duplications via chromosomal microarray testing, were enrolled in this study. Four of their female relatives, who were verified as carriers of MECP2 duplications, were also included. Genomic copy numbers of MECP2 and IRAK1 were analyzed in comparison with reference genes: XIST and AR on the X-chromosome, and RPP30 and RPPH1 on the autosomal chromosomes. As a result, genomic copy numbers of MECP2 were rapidly and precisely detected by the dPCR system established in this study. This method can be widely applied as a diagnostic method to confirm CNVs on other chromosomal regions. 相似文献
7.
8.
9.
Neonatal lupus erythematosus (LE) is a rare immune-mediated disease caused by placental transport of maternal anti-SSA/Ro, anti-SSB/La and/or anti-U1RNP antibodies. Here, we demonstrate two cases of neonatal LE, in both of which cutaneous LE was exacerbated by inoculation. To our knowledge, cases worsening neonatal LE after administration of vaccines have not been reported. In case 1, not only exacerbation of pre-existing annular erythema but also spreading of new erythematous lesions to the trunk and extremities were induced following vaccination. Of interest, all of the lesions simultaneously improved. By contrast, in case 2, pre-existing facial erythema became prominent without spreading to other sites. The mother of case 1 had Sjögren’s syndrome, whereas in case 2, the mother was diagnosed with Sjögren’s syndrome on this occasion for the first time. Immunohistochemistry in case 1 revealed interleukin (IL)-17-positive cells infiltrating into the papillary dermis, and CD123-positive plasmacytoid dendritic cells in the papillary dermis and the deep reticular dermis. Both innate immune response and IL-17 mediated inflammation following vaccination are speculated as a possible mechanism of the deterioration of LE lesions in our juvenile cases. Caution is necessary since neonatal LE can be worsened following vaccination. 相似文献