全文获取类型
收费全文 | 1158篇 |
免费 | 87篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 52篇 |
妇产科学 | 16篇 |
基础医学 | 160篇 |
口腔科学 | 16篇 |
临床医学 | 57篇 |
内科学 | 346篇 |
皮肤病学 | 68篇 |
神经病学 | 75篇 |
特种医学 | 39篇 |
外科学 | 204篇 |
综合类 | 3篇 |
预防医学 | 30篇 |
眼科学 | 7篇 |
药学 | 80篇 |
中国医学 | 1篇 |
肿瘤学 | 88篇 |
出版年
2023年 | 12篇 |
2021年 | 34篇 |
2020年 | 23篇 |
2019年 | 32篇 |
2018年 | 48篇 |
2017年 | 36篇 |
2016年 | 38篇 |
2015年 | 31篇 |
2014年 | 29篇 |
2013年 | 48篇 |
2012年 | 65篇 |
2011年 | 66篇 |
2010年 | 32篇 |
2009年 | 28篇 |
2008年 | 46篇 |
2007年 | 48篇 |
2006年 | 63篇 |
2005年 | 51篇 |
2004年 | 58篇 |
2003年 | 44篇 |
2002年 | 36篇 |
2001年 | 30篇 |
2000年 | 36篇 |
1999年 | 18篇 |
1998年 | 16篇 |
1997年 | 13篇 |
1996年 | 10篇 |
1995年 | 9篇 |
1994年 | 10篇 |
1993年 | 12篇 |
1992年 | 24篇 |
1991年 | 29篇 |
1990年 | 16篇 |
1989年 | 18篇 |
1988年 | 17篇 |
1987年 | 13篇 |
1986年 | 25篇 |
1985年 | 21篇 |
1984年 | 10篇 |
1983年 | 11篇 |
1980年 | 5篇 |
1979年 | 5篇 |
1978年 | 3篇 |
1977年 | 6篇 |
1975年 | 2篇 |
1974年 | 2篇 |
1969年 | 4篇 |
1968年 | 3篇 |
1967年 | 3篇 |
1966年 | 4篇 |
排序方式: 共有1250条查询结果,搜索用时 171 毫秒
1.
2.
Hiroko Yamashita Takashi Morita Michiko Ito Shizuka Okazaki Mototaka Koto Yuri Ichikawa Ryoko Takayama Toshihiko Hoashi Hidehisa Saeki Naoko Kanda 《The Journal of dermatology》2019,46(9):759-769
Psoriasis is characterized by T‐helper 17 cell‐dominant abnormal immunity, and hyperproliferation and abnormal differentiation of epidermal keratinocytes. Some patients are associated with arthritis. Dietary habits can modulate the pathogenesis of psoriasis. Previous studies in Western countries showed higher body mass indices, higher intake of fat and lower intake of fish or vegetables in psoriatic patients compared with the reference groups. We evaluated dietary habits in adult Japanese psoriatic patients, using a validated brief‐type self‐administered dietary history questionnaire, and compared the results to those of age‐ and sex‐matched healthy controls. The results in psoriatic patients with arthritis were compared with those in the patients without. Japanese psoriatic patients showed higher body mass indices, higher intake of fish/shellfish, pulses, sugar/sweeteners, vitamin B12 and vitamin D, and lower intake of meat, compared with those of healthy controls. The logistic regression analysis showed that psoriasis was associated with high body mass index and low intake of meat. The intake of confection in patients with high Psoriasis Area and Severity Index was higher than that in those with low index. The intake of β‐carotene, vitamin A and green/yellow vegetables in psoriatic patients with arthritis were higher than those in the patients without. The dietary habits in Japanese psoriatic patients are rather different from those in Western patients. This is the first study showing the differences in dietary habits between psoriatic patients with arthritis and those without. Further studies should elucidate the relationships of these results with skin and joint lesions in psoriatic patients. 相似文献
3.
Comparison of hospitalization risk before and after changing from risperidone long‐acting injection to another long‐acting injection or oral antipsychotic in patients with schizophrenia: Mirror‐image study 下载免费PDF全文
4.
5.
6.
7.
8.
Takaya Handa Hiroko Kakita Yu Tateishi Tomomi Endo Hiroyuki Suzuki Toshiro Katayama Tatsuo Tsukamoto Eri Muso 《Clinical and experimental nephrology》2018,22(5):1116-1127
Background
IgA-dominant infection-related glomerulonephritis (IgA-IRGN) is a unique form of IRGN, which needs to be distinguished from IgA nephropathy (IgAN).Methods
Thirteen patients with IgA-IRGN (IgA-IRGN group) and 122 with IgAN (IgAN group) were selected from 1788 patients who underwent kidney biopsy between 2000 and 2015 in Kitano Hospital. Data selected included clinical and serological parameters; light and electron microscope findings; immunofluorescence findings; and prognostic parameters like renal and overall survival and creatinine increase by >?50%. In addition, a 26-patient IgAN cohort (matching-IgAN), matching with IgA-IRGN group with respect to age, sex, estimated glomerular filtration rate (eGFR), and proteinuria was segregated for comparison.Results
Compared to IgAN group, IgA-IRGN group were older, had lower hemoglobin, higher CRP, lower eGFR, heavier proteinuria, lower serum albumin, and higher serum IgG and IgA levels (p?<?0.05). Endocapillary hypercellularity, deposition of immune complexes along the glomerular capillary wall, and subendothelial and subepithelial electron dense deposits were more frequently observed (p?<?0.05); and they were more susceptible to renal dysfunction and poorer prognosis. After propensity score-matching, serum albumin was significantly lower in the IgA-IRGN group. Significantly subendothelial and subepithelial deposits were frequently observed in this group. Matching-IgAN group showed relatively advanced sclerotic lesions with more global sclerosis and fibrous crescent.Conclusion
Local inflammation involved glomerular capillary wall in IgA-IRGN, in contrast to relatively chronic and sclerotic renal lesion in IgAN, might result in poorer prognosis in former, even under indistinguishable condition of deteriorated renal function and proteinuria.9.
Kochi Masatoshi Hinoi Takao Niitsu Hiroaki Ohdan Hideki Konishi Fumio Kinugasa Yusuke Kobatake Takaya Ito Masaaki Inomata Masafumi Yatsuoka Toshimasa Ueki Takashi Tashiro Jo Yamaguchi Shigeki Watanabe Masahiko 《Surgery today》2018,48(8):756-764
Surgery Today - Postoperative pneumonia affects the length of stay and mortality after surgery in elderly patients with colorectal cancer (CRC). We aimed to determine the risk factors of... 相似文献
10.
Katsushi Takebayashi Masakata Matsumura Yasuhiro Kawai Takahiko Hoashi Nagato Katsura Seijun Fukuda Kenji Shimizu Takuji Inada Masugi Sato 《International surgery》2015,100(4):666-671
We aimed to assess the efficacy of transversus abdominis plane (TAP) block and rectus sheath (RS) block in patients undergoing laparoscopic inguinal hernia surgery. Few studies have addressed the efficacy and safety associated with TAP block and RS block for laparoscopic surgery. Thirty-two patients underwent laparoscopic inguinal hernia surgery, either with TAP and RS block (Block+ group, n = 18) or without peripheral nerve block (Block− group, n = 14). Preoperatively, TAP and RS block were performed through ultrasound guidance. We evaluated postoperative pain control and patient outcomes. The mean postoperative hospital stays were 1.56 days (Block+ group) and 2.07 days (Block− group; range, 1–3 days in both groups; P = 0.0038). A total of 11 patients and 1 patient underwent day surgery in the Block+ and Block− groups, respectively (P = 0.0012). Good postoperative pain control was more commonly observed in the Block+ group than in the Block− group (P = 0.011). TAP and RS block was effective in reducing postoperative pain and was associated with a fast recovery in patients undergoing laparoscopic inguinal hernia surgery.Key words: TAP block, RS block, Inguinal hernia, Laparoscopic surgeryInguinal hernia repair is one of the most frequently performed surgical operations. The debate regarding the best repair technique for inguinal hernia is ongoing. Several trials have compared the efficacy of the Lichtenstein and laparoscopic approach for inguinal hernia repair.1–6 Laparoscopic repair of inguinal hernia has certain advantages over open repair, such as reduced postoperative pain and morbidity, early recovery, rapid return to work, and better quality of life.3–7 Several strategies have been reported to ameliorate postoperative pain in laparoscopic surgery.8The transversus abdominis plane (TAP) block is a regional anesthetic technique that provides analgesia to the parietal peritoneum as well as to the skin and muscles of the anterior abdominal wall.9,10 Despite a relatively low risk of complications and a high success rate using modern techniques, TAP block remains overwhelmingly underused. Although the technique is technically straightforward, it has not been adopted in clinical practice.9,11 Moreover, rectus sheath (RS) block has been reported to be effective for pain management in patients undergoing umbilical hernia repair surgery.12Generally, in laparoscopic inguinal hernia surgery, the sites of port incision are on the umbilical and bilateral middle abdomen. Those sites are associated with considerable postoperative discomfort. Thus, we performed TAP and RS block to ameliorate postoperative pain and improve patient outcomes. Here, we aimed to assess the efficacy of TAP and RS block in patients undergoing laparoscopic inguinal hernia surgery. 相似文献