全文获取类型
收费全文 | 1707篇 |
免费 | 158篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 62篇 |
妇产科学 | 32篇 |
基础医学 | 351篇 |
口腔科学 | 12篇 |
临床医学 | 149篇 |
内科学 | 350篇 |
皮肤病学 | 28篇 |
神经病学 | 80篇 |
特种医学 | 68篇 |
外科学 | 167篇 |
综合类 | 80篇 |
一般理论 | 1篇 |
预防医学 | 150篇 |
眼科学 | 17篇 |
药学 | 168篇 |
中国医学 | 25篇 |
肿瘤学 | 109篇 |
出版年
2023年 | 12篇 |
2022年 | 12篇 |
2021年 | 76篇 |
2020年 | 56篇 |
2019年 | 46篇 |
2018年 | 54篇 |
2017年 | 50篇 |
2016年 | 43篇 |
2015年 | 55篇 |
2014年 | 79篇 |
2013年 | 75篇 |
2012年 | 130篇 |
2011年 | 127篇 |
2010年 | 65篇 |
2009年 | 60篇 |
2008年 | 76篇 |
2007年 | 83篇 |
2006年 | 69篇 |
2005年 | 54篇 |
2004年 | 66篇 |
2003年 | 74篇 |
2002年 | 63篇 |
2001年 | 47篇 |
2000年 | 49篇 |
1999年 | 30篇 |
1998年 | 15篇 |
1997年 | 10篇 |
1996年 | 9篇 |
1995年 | 8篇 |
1994年 | 13篇 |
1993年 | 12篇 |
1992年 | 19篇 |
1991年 | 13篇 |
1990年 | 21篇 |
1989年 | 22篇 |
1988年 | 17篇 |
1987年 | 14篇 |
1986年 | 11篇 |
1985年 | 7篇 |
1983年 | 5篇 |
1981年 | 5篇 |
1978年 | 4篇 |
1976年 | 5篇 |
1975年 | 7篇 |
1974年 | 9篇 |
1973年 | 8篇 |
1972年 | 5篇 |
1971年 | 6篇 |
1970年 | 7篇 |
1968年 | 5篇 |
排序方式: 共有1866条查询结果,搜索用时 62 毫秒
1.
Anand Rajan Peerapol Wangrattanapranee Jonathan Kessler Trilokesh Dey Kidambi James H Tabibian 《World journal of gastrointestinal surgery》2022,14(4):286-303
Gastrostomy tube placement is a procedure that achieves enteral access for nutrition, decompression, and medication administration. Preprocedural evaluation and selection of patients is necessary to provide optimal benefit and reduce the risk of adverse events (AEs). Appropriate indications, contraindications, ethical considerations, and comorbidities of patients referred for gastrostomy placement should be weighed and balanced. Additionally, endoscopist should consider either a transoral or transabdominal approach is appropriate, and radiologic or surgical gastrostomy tube placement is needed. However, medical history, physical examination, and imaging prior to the procedure should be considered to tailor the appropriate approach and reduce the risk of AEs. 相似文献
2.
Nazmul Hassan Rafiqul Islam Kaniz Fathem Maimuna Sayee Md. Wahiduzzaman Mazumder ASM Bazlul Karim Bishnu Pada Dey 《中国当代儿科杂志》2020,22(12):1338-1343
肝外胆道肿瘤罕见,其中以横纹肌肉瘤最常见。横纹肌肉瘤是一种软组织恶性肌肉骨骼肿瘤,是儿童非常罕见的一种胆总管恶性肿瘤。它通常表现为阻塞性黄疸和/或瘙痒。如果肿瘤没有局部浸润邻近组织,其影像学表现则类似胆总管囊肿。因此,确诊通常是在手术时或术前通过活检。早期诊断、与胆总管囊肿鉴别、尽早开始治疗对延长患者生存时间有重要意义。该文报道1例10岁男童,反复阻塞性黄疸和发热,术前诊断为胆总管囊肿,术后确诊为胆总管胚胎性横纹肌肉瘤。经手术切除、术后化疗,该患儿预后良好。故必须了解这种罕见的肿瘤可以类似先天性胆总管囊肿,并且在儿童阻塞性黄疸的鉴别诊断时应加以考虑。 相似文献
3.
Andrew P. Costa PhD John P. Hirdes PhD George A. Heckman MD MSc Aparajit B. Dey MD Palmi V. Jonsson MD Prabha Lakhan RN PhD Gunnar Ljunggren MD PhD Katrin Singler MD MME Fredrik Sjostrand MD PhD Walter Swoboda MD Nathalie I.H. Wellens PhD Leonard C. Gray MD PhD 《Academic emergency medicine》2014,21(4):422-433
4.
5.
6.
Singh Simron Dey Chris Kennecke Hagen Kocha Walter Maroun Jean Metrakos Peter Mukhtar Tariq Pasieka Janice Rayson Daniel Rowsell Corwyn Sideris Lucas Wong Ralph Law Calvin 《Annals of surgical oncology》2015,22(8):2685-2699
Annals of Surgical Oncology - Pancreatic neuroendocrine tumors (pNETs) are rare heterogeneous tumors that have been steadily increasing in both incidence and prevalence during the past few decades.... 相似文献
7.
Oral Diseases (2011) 17 , 801–807 Objective: Sjögren’s syndrome is a chronic autoimmune disorder characterized by progressive lymphocytic infiltration within the salivary and lacrimal glands. This study was undertaken to investigate the effects of innate immunity activation on sialoadenitis in a mouse strain genetically susceptible for development of SS‐like disease. Methods: Female New Zealand Black X New Zealand White F1 mice were repeatedly treated with toll‐like 3 receptor agonist poly(I:C). Submandibular glands were investigated at different time points for sialoadenitis by immunohistochemistry and for gene expression of different chemokines by quantitative PCR. Submandibular gland–infiltrating cells were characterized by flow cytometry. Results: Poly(I:C) treatment significantly upregulated the expression of multiple chemokines within the submandibular glands. The severity and incidence of sialoadenitis was considerably higher in poly(I:C)‐treated mice. There was a preponderance of dendritic cells and NK cells in the initial inflammatory cell infiltrates, and these were followed by CD4+ T cells. Conclusions: Our data clearly demonstrate that systemic activation of innate immunity accelerates sialoadenitis in a mouse model for SS‐like disease. These findings suggest that chronic activation of innate immunity can influence certain features of SS. 相似文献
8.
Biswajit Kumar Biswas Sutapa Dey Anindya Chakrabarty Arghya Laha Tapan Kumar Mandal Laxmikanta Karmakar Debajyoti Das 《Artificial organs》2020,44(11):E494-E508
Cartilage is avascular with limited to no regenerative capacity, so its loss could be a challenge for reconstructive surgery. Current treatment options for damaged cartilage are also limited. In this aspect there is a tremendous need to develop an ideal cartilage-mimicking biomaterial that could repair maxillofacial defects. Considering this fact in this study we have prepared twelve silicone-based materials (using Silicone 40, 60, and 80) reinforced with hydroxyapatite, tri-calcium phosphate, and titanium dioxide which itself has proven their efficacy in several studies and able to complement the shortcomings of using silicones. Among the mechanical properties (Young’s modulus, tensile strength, percent elongation, and hardness), hardness of Silicone-40 showed similarities with goat ear (P > .05). Silicone peaks have been detected in FTIR. Both AFM morphology and SEM images of the samples confirmed more roughed surfaces. All the materials were nonhemolytic in hemocompatibility tests, but among the twelve materials S2, S3, S5, and S6 showed the least hemolysis. For all tested bacterial strains, adherence was lower on each material than that grown on the plain industrial silicone material which was used as a positive control. S2, S3, S5, and S6 samples were selected as the best based on mechanical characterizations, surface characterizations, in vitro hemocompatibility tests and bacterial adherence activity. So, outcomes of this present study would be promising when developing ideal cartilage-mimicking biocomposites and their emerging applications to treat maxillofacial defects due to cartilage damage. 相似文献
9.
Robert J. H. Miller Jacek Kwiecinski Kevin S. Shah Evann Eisenberg Jignesh Patel Jon A. Kobashigawa Babak Azarbal Balaji Tamarappoo Daniel S. Berman Piotr J. Slomka Evan Kransdorf Damini Dey 《American journal of transplantation》2020,20(5):1375-1383
Cardiac allograft vasculopathy (CAV) is an increasingly important complication after cardiac transplant. We assessed the additive diagnostic benefit of quantitative plaque analysis in patients undergoing coronary computed tomography–angiography (CCTA). Consecutive patients undergoing CCTA for CAV surveillance were identified. Scans were visually interpreted for coronary stenosis. Semiautomated software was used to quantify noncalcified plaque (NCP), as well as its components. Optimal diagnostic cut‐offs for CAV, with coronary angiography as gold standard, were defined using receiver operating characteristic curves. In total, 36 scans were identified in 17 patients. CAV was present in 17 (46.0%) reference coronary angiograms, at a median of 1.9 years before CCTA. Median NCP (147 vs 58, P < .001), low‐density NCP (median 4.5 vs 0.9, P = .003), fibrous plaque (median 76.1 vs 31.1, P = .003), and fibrofatty plaque (median 63.6 vs 27.6, P < .001) volumes were higher in patients with CAV, whereas calcified plaque was not (median 0.0 vs 0.0, P = .510). Visual assessment of CCTA alone was 70.6% sensitive and 100% specific for CAV. The addition of total NCP volume increased sensitivity to 82.4% while maintaining 100% specificity. NCP volume is significantly higher in patients with CAV. The addition of quantitative analysis to visual interpretation improves the sensitivity for detecting CAV without reducing specificity. 相似文献
10.
Severity of S. aureus septic arthritis is correlated to prolonged inflammation by inflammatory cytokines like TNF-α, IL-1β, and IL-6 even after successful elimination of bacteria. Role of TNF-α via TNFR2 is not well established in this aspect. IFN-γ induces TNF-α release from the macrophages augmenting the inflammatory arthritis. IL-10 modulates the levels of pro-inflammatory cytokines promoting resolution of inflammation. TNF-α-TNFR2 signaling upregulates both of these cytokines. Higher level of MMP-2 induction by inflammatory cytokines during arthritis promotes tissue destruction. Whether dual neutralization of TNFR-2 and MMP-2 regulates the severity of S. aureus arthritis by modulating local and systemic cytokine milieu mainly due to TNFR-2 blocking was an obvious question. Here, we attempted the effects of neutralization of MMP-2 and TNFR2 on S. aureus arthritis and its impact on pro-inflammatory cytokines and some other parameters related to tissue destruction. Reduction in arthritis index was noticed in infected mice treated with both MMP-2 inhibitor and TNFR2 antibody. Lowest levels of inflammatory cytokines, iNOS, RANKL, NF-κb, JNK kinase, ROS, and MPO, and lysozyme activity were observed in combined neutralization group at 9 and 15 dpi, but at 3 dpi, most of the above parameters remained elevated due to TNFR2 neutralization. Diminished IL-10 and IFN-γ levels as a result of TNFR2 neutralization at early and later phase of infection respectively might be responsible for these contrasting effects. Overall, it can be suggested that administration of MMP-2 inhibitor and TNFR2 antibody in combination is protective against the inflammation and tissue destruction associated with S. aureus infection during the arthritic episode. 相似文献