全文获取类型
收费全文 | 8685篇 |
免费 | 415篇 |
国内免费 | 95篇 |
专业分类
耳鼻咽喉 | 74篇 |
儿科学 | 152篇 |
妇产科学 | 165篇 |
基础医学 | 906篇 |
口腔科学 | 140篇 |
临床医学 | 520篇 |
内科学 | 2263篇 |
皮肤病学 | 240篇 |
神经病学 | 504篇 |
特种医学 | 297篇 |
外科学 | 1894篇 |
综合类 | 18篇 |
一般理论 | 1篇 |
预防医学 | 202篇 |
眼科学 | 191篇 |
药学 | 414篇 |
中国医学 | 17篇 |
肿瘤学 | 1197篇 |
出版年
2023年 | 65篇 |
2022年 | 55篇 |
2021年 | 204篇 |
2020年 | 124篇 |
2019年 | 153篇 |
2018年 | 240篇 |
2017年 | 161篇 |
2016年 | 182篇 |
2015年 | 222篇 |
2014年 | 274篇 |
2013年 | 347篇 |
2012年 | 589篇 |
2011年 | 700篇 |
2010年 | 381篇 |
2009年 | 346篇 |
2008年 | 618篇 |
2007年 | 631篇 |
2006年 | 575篇 |
2005年 | 581篇 |
2004年 | 492篇 |
2003年 | 504篇 |
2002年 | 438篇 |
2001年 | 117篇 |
2000年 | 95篇 |
1999年 | 99篇 |
1998年 | 111篇 |
1997年 | 64篇 |
1996年 | 72篇 |
1995年 | 50篇 |
1994年 | 65篇 |
1993年 | 48篇 |
1992年 | 61篇 |
1991年 | 47篇 |
1990年 | 52篇 |
1989年 | 40篇 |
1988年 | 52篇 |
1987年 | 44篇 |
1986年 | 37篇 |
1985年 | 29篇 |
1984年 | 29篇 |
1983年 | 24篇 |
1982年 | 15篇 |
1981年 | 13篇 |
1979年 | 10篇 |
1978年 | 16篇 |
1977年 | 16篇 |
1976年 | 9篇 |
1975年 | 12篇 |
1971年 | 12篇 |
1970年 | 13篇 |
排序方式: 共有9195条查询结果,搜索用时 0 毫秒
1.
Yuka Ikeda Kurumi Taniguchi Haruka Sawamura Ai Tsuji Satoru Matsuda 《World journal of gastroenterology : WJG》2022,28(31):4471-4474
Irritable bowel syndrome (IBS) is an important health care concern. Alterations in the microbiota of the gut-brain axis may be linked to the pathophysiology of IBS. Some dietary intake could contribute to produce various metabolites including D-amino acids by the fermentation by the gut microbiota. D-amino acids are the enantiomeric counterparts of L-amino acids, in general, which could play key roles in cellular physiological processes against various oxidative stresses. Therefore, the presence of D-amino acids has been shown to be linked to the protection of several organs in the body. In particular, the gut microbiota could play significant roles in the stability of emotion via the action of D-amino acids. Here, we would like to shed light on the roles of D-amino acids, which could be used for the treatment of IBS. 相似文献
2.
3.
Takaki Shimizu Satoshi Kato Satoru Demura Kazuya Shinmura Noriaki Yokogawa Yuki Kurokawa Noritaka Yonezawa Norihiro Oku Ryo Kitagawa Makoto Handa Ryohei Annen Yoshiyuki Okamoto Hideki Murakami Hiroyuki Tsuchiya 《Journal of orthopaedic science》2021,26(3):327-331
BackgroundLocomotive syndrome is a condition of reduced mobility due to problems with locomotive organs. Although lumbar spinal canal stenosis is one of the major diseases constituting locomotive syndrome, only few studies have focused on the association between the two pathologies. We aimed to investigate the effect of surgery on lumbar spinal canal stenosis with respect to locomotive syndrome using various physical function tests, including locomotive syndrome risk tests, before and after surgery.MethodsClinical data of 101 consecutive patients (male = 46; female = 55; mean age, 69.3 years) who underwent surgery for lumbar spinal canal stenosis at our institute were prospectively collected. Results of physical function tests, including stand-up test, two-step test, and 25-Question Geriatric Locomotive Function Scale, and the sagittal vertical axis were evaluated before and 1 year after surgery. The association between several parameters and improvement of risk level in locomotive syndrome was evaluated.ResultsIn the total assessment, 93.1% of cases were in stage 2 and 6.9% in stage 1 preoperatively, while 72.4% were in stage 2, 22.4% in stage 1, and 5.2% in stage 0 at 1 year postoperatively. Postoperative improvement in the total assessment was observed in 28.7% of cases. Several physical function tests and sagittal vertical axis showed significant improvement after surgery. On multiple logistic regression analysis, age >75 years (odds ratio = 10.9, confidence interval = 1.09–109) and postoperative sagittal vertical axis >40 mm (odds ratio = 17.8, confidence interval = 1.78–177) were significant risk factors associated with non-improvement in risk level of locomotive syndrome.ConclusionsSurgical treatment for lumbar spinal canal stenosis improved physical function, including locomotive syndrome. Risk factors associated with non-improvement of locomotive syndrome were later-stage elderly and postoperative sagittal balance impairment. 相似文献
4.
5.
6.
7.
8.
neurogenetics - Mediator (MED) is a key regulator of protein-coding gene expression, and mutations in MED subunits are associated with a broad spectrum of diseases. Because mutations in MED17... 相似文献
9.
Chikako Kusunoki Takuya Hamakawa Kazuhiro Nishikawa Hiromichi Sato Sayumi Imamura Satoru Miyahara Yu Sakano Hazuki Miyazaki Hiroto Seto Ryuta Ueda Reishi Toshiyama Masaaki Miyo Yusuke Takahashi Kenji Sakai Masakazu Miyake Atsushi Miyamoto Takeshi Kato Kiyoshi Mori Motohiro Hirao 《Asian journal of endoscopic surgery》2021,14(4):794-797
Laparoscopic wedge resection (LWR) for intraluminal gastrointestinal stromal tumor (GIST) leads to excessive resection of normal gastric wall. We report a case of GIST around the cardia successfully treated with full-thickness partial resection using a hybrid approach of laparoscopic surgery and single-incision intragastric surgery (SIIGS). A 69-year-old woman had a 5 cm intraluminal GIST at the posterior wall around the cardia. Submucosal injection of glycerin and indigo carmine was performed with transoral endoscopy. Circumferential seromuscular incision followed by placement of seromuscular sutures to invert the lesion into the stomach was performed under laparoscopy. By SIIGS, resection of the inverted mucosa and retrieval of the tumor were completed. A hybrid approach consisting of laparoscopic wall-inversion surgery and SIIGS was useful for intraluminal GIST and may expand the indications for laparoscopic wall-inversion surgery by removing size limitations. 相似文献
10.