排序方式: 共有16条查询结果,搜索用时 0 毫秒
1.
Phantana-angkool April Voci Amy E. Warren Yancey E. Livasy Chad A. Beasley Lakesha M. Robinson Myra M. Hadzikadic-Gusic Lejla Sarantou Terry Forster Meghan R. Sarma Deba White Richard L. 《Annals of surgical oncology》2019,26(12):3874-3882
Annals of Surgical Oncology - The role of sentinel lymph node biopsy (SLNB) when ductal carcinoma in situ with microinvasion (DCISM) is identified on core biopsy is unclear. Our aim was to assess... 相似文献
2.
3.
The first recorded case of a metachronous second primary malignant fibrous histiocytoma (MFH) of soft tissue is presented. The patient, who has been followed every two months since the treatment of his buttock sarcoma by neoadjuvant therapy, is free of disease 24 months later. The clinical presentations, different histologies, and DNA contents of these two MFHs are consistent with metachronous primary sarcomas. The literature on second primary neoplasms is discussed. 相似文献
4.
5.
Reporting of mitotic rate in cutaneous melanoma: A study using the national cancer data base 下载免费PDF全文
6.
Jacquelyn A.V. Palmer Teresa Flippo-Morton Kendall K. Walsh Lejla Hadzikadic Gusic Terry Sarantou Myra M. Robinson Richard L. White 《Clinical breast cancer》2018,18(4):270-275
Background
The ACOSOG (American College of Surgeons Oncology Group) Z1071 assessed the feasibility of performing sentinel lymph node biopsy (SLNB) in node-positive patients who completed neoadjuvant chemotherapy (NACT). Historically, adoption of clinical research into practice takes years. The goal of this study was to determine the effect of Z1071 on our practice.Materials and Methods
This is a retrospective review of Z1071’s influence on a single institution’s practice. Patients with biopsy-proven positive axillary lymph nodes before NACT were eligible for the study. After NACT, patients with nodal response according to imaging and exam were candidates for SLNB. Two cohorts were stratified according to diagnosis date before and after Z1071 results were presented on December 5, 2012 at the San Antonio Breast Cancer Symposium. Fisher exact tests and nonparametric rank tests were used to compare cohorts.Results
The pre-Z1071 cohort included 74 patients and the post-Z1071 cohort 56 for a total of 130 patients. Post-Z1071, 73% (41/56) underwent a SLNB with an average of 4 nodes removed. Moreover, 27% (15/56) of patients had an axillary lymph node dissection as first intervention post-Z1071, compared with 99% (73/74) pre-Z1071. Axillary pathologic complete response pre-Z1071 was 35% (26/74) and post-Z1071 was 27% (15/56) (P = .35).Conclusion
This report shows that meaningful practice changes can be implemented rapidly. Changes in practice generated by clinical trial results should be monitored and outcomes followed. 相似文献7.
Dr. S. David Nathanson MD Patricia Anaya MS Mary Avery PhD Fred W. Hetzel PhD Terry Sarantou MD Suzanne Havstad MS 《Annals of surgical oncology》1997,4(2):161-168
Background: This study was designed to investigate the relationships among primary tumor size, lymphatic vessel diameters, the incidence of sentinel lymph node (SLN) metastasis and lymphatic clearance from murine footpad melanomas.
Methods: Lymphatic clearance (LC) of [99mTc]HSA from the middle of the footpad of syngeneic C57BL/6 mice, with or without primary melanomas (sizes varying from 1 to 5 mm in anteroposterior diameter), was quantitated using a gamma scintillation detection system. Lymphatic vessel diameters (LD) were measured after injection of aniline blue dye into footpad tumors. The incidence of SLN, femoral lymph node (FLN), and lung metastases was recorded.
Results: Metastasis to SLNs increased as tumor growth progressed (r=0.976, p=0.001), and there was a correlation between tumor size and both FLN (p=0.041) and lung (p=0.055) metastases. There was also a correlation between lymph node metastasis and LC (r=0.83, p=0.04) and LD (r=0.84, p=0.04).
Conclusions: These studies support the hypothesis that lymph flow and LD is increased in experimental murine melanomas and this relates to both primary tumor size and to lymphatic and hematogenous metastasis.Supported in part by CA 43709, NIH/NCI and the Stephen A. Bryant Fund.Presented at the 49th Annual Cancer Symposium of The Society of Surgical Oncology, Atlanta, Georgia, March 21–24, 1996. 相似文献
8.
Changes in margin re‐excision rates: Experience incorporating the “no ink on tumor” guideline into practice 下载免费PDF全文
9.
Peter J. Bostick Kelly T. Huynh Terry Sarantou Roderick R. Turner Karen Qi Armando E. Giuliano Dave S. B. Hoon 《International journal of cancer. Journal international du cancer》1998,79(6):645-651
This study was undertaken to assess a multiple-marker RT-PCR and Southern blot assay for detection of metastases in frozen sections of sentinel lymph nodes from breast cancer patients. Sentinel lymphadenectomy was performed in 41 AJCC (American Joint Committee on Cancer) stage I-IIIA breast cancer patients and 57 sentinel nodes (SNs) were excised. The SN, which is the first node in the lymphatic basin to receive metastases from the primary tumor, was identified using isosulfan blue dye. Hematoxylin and eosin (H&E), immuno-histochemistry (IHC) and RT-PCR were performed on adjacent sections of the SN. Six consecutive 12-μm frozen sections of each SN were obtained for the RT-PCR assay to determine expression of mRNA tumor markers C-Met, β1 → 4GalNAc-T and P97. Metastatic breast cancer was detected by H&E in 10 of 57 (18%) SNs and by IHC in an additional 7 (12%). Only 1 of 17 (6%) SNs with metastases did not express any of the 3 tumor mRNA markers. C-Met, β1 → 4GalNAc-T and P97 tumor mRNA markers were expressed in 31 (78%), 21 (53%) and 25 (63%) of 40 SNs without metastases, respectively. At least 2 mRNA tumor markers were expressed in 25/40 (63%) histo-pathologically tumor-free SNs, whereas all 3 mRNA tumor markers were expressed in 17/40 (43%) SNs. Expression of all 3 mRNA tumor markers in a SN was significantly higher in patients with a family history of breast cancer (p= 0.05), prior history of breast cancer (p< 0.05), infiltrating lobular carcinoma (p = 0.06), estrogen receptor-negative (p= 0.04) tumor or a higher Bloom Richardson score (p= 0.04). The multiple-marker RT-PCR and Southern blot assay improves the detection of occult metastases in the SN when compared to conventional H&E and IHC analysis. Expression of all 3 tumor mRNA markers in the SN correlated with poor prognostic clinico-pathologic factors compared to expression of 0 to 2 markers. Int. J. Cancer (Pred. Oncol.) 79:645–651, 1998. © 1998 Wiley-Liss, Inc. 相似文献
10.
Margin re‐excision and local recurrence in invasive breast cancer: A cost analysis using a decision tree model 下载免费PDF全文