全文获取类型
收费全文 | 10262篇 |
免费 | 533篇 |
国内免费 | 40篇 |
专业分类
耳鼻咽喉 | 103篇 |
儿科学 | 521篇 |
妇产科学 | 278篇 |
基础医学 | 1096篇 |
口腔科学 | 197篇 |
临床医学 | 636篇 |
内科学 | 2531篇 |
皮肤病学 | 255篇 |
神经病学 | 686篇 |
特种医学 | 474篇 |
外科学 | 1760篇 |
综合类 | 194篇 |
一般理论 | 5篇 |
预防医学 | 434篇 |
眼科学 | 328篇 |
药学 | 627篇 |
中国医学 | 27篇 |
肿瘤学 | 683篇 |
出版年
2023年 | 62篇 |
2022年 | 47篇 |
2021年 | 250篇 |
2020年 | 195篇 |
2019年 | 213篇 |
2018年 | 281篇 |
2017年 | 213篇 |
2016年 | 278篇 |
2015年 | 284篇 |
2014年 | 464篇 |
2013年 | 530篇 |
2012年 | 880篇 |
2011年 | 928篇 |
2010年 | 522篇 |
2009年 | 421篇 |
2008年 | 667篇 |
2007年 | 711篇 |
2006年 | 676篇 |
2005年 | 569篇 |
2004年 | 568篇 |
2003年 | 473篇 |
2002年 | 417篇 |
2001年 | 122篇 |
2000年 | 96篇 |
1999年 | 102篇 |
1998年 | 81篇 |
1997年 | 57篇 |
1996年 | 49篇 |
1995年 | 49篇 |
1994年 | 39篇 |
1993年 | 29篇 |
1992年 | 41篇 |
1991年 | 51篇 |
1990年 | 54篇 |
1989年 | 42篇 |
1988年 | 52篇 |
1987年 | 37篇 |
1986年 | 29篇 |
1985年 | 26篇 |
1984年 | 15篇 |
1983年 | 23篇 |
1978年 | 12篇 |
1977年 | 15篇 |
1976年 | 15篇 |
1975年 | 18篇 |
1973年 | 15篇 |
1972年 | 15篇 |
1971年 | 13篇 |
1970年 | 15篇 |
1968年 | 12篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
The proximity and continuity of the oral cavity and the lower respiratory tract allows the oropharyngeal microbiome to be a major determinant of the lung microbiome. In addition, host-pathogen interactions related to the oropharyngeal microbiome or its metabolites could propagate systemic inflammation or modulate host defense mechanisms that could affect other organs, including the lung. There is increasing appreciation of the pathophysiologic significance of the lung microbiome, not only in the classical infection-related diseases, pneumonia, bronchiectasis, and cystic fibrosis, but also in chronic noninfectious lung diseases, such as chronic obstructive pulmonary disease, asthma, and pulmonary fibrosis. In this review, we will explore the relationship of the oral microbiome with lung diseases, such as pneumonia, chronic obstructive pulmonary disease, asthma, and cystic fibrosis. 相似文献
6.
7.
8.
9.
Prahlad V. Raninga Andy C. Lee Debottam Sinha Yu-Yin Shih Deepak Mittal Ashwini Makhale Amanda L. Bain Devathri Nanayakarra Kathryn F. Tonissen Murugan Kalimutho Kum Kum Khanna 《International journal of cancer. Journal international du cancer》2020,146(1):123-136
Triple-negative breast cancer (TNBCs) is a very aggressive and lethal form of breast cancer with no effective targeted therapy. Neoadjuvant chemotherapies and radiotherapy remains a mainstay of treatment with only 25–30% of TNBC patients responding. Thus, there is an unmet clinical need to develop novel therapeutic strategies for TNBCs. TNBC cells have increased intracellular oxidative stress and suppressed glutathione, a major antioxidant system, but still, are protected against higher oxidative stress. We screened a panel of antioxidant genes using the TCGA and METABRIC databases and found that expression of the thioredoxin pathway genes is significantly upregulated in TNBC patients compared to non-TNBC patients and is correlated with adverse survival outcomes. Treatment with auranofin (AF), an FDA-approved thioredoxin reductase inhibitor caused specific cell death and impaired the growth of TNBC cells grown as spheroids. Furthermore, AF treatment exerted a significant in vivo antitumor activity in multiple TNBC models including the syngeneic 4T1.2 model, MDA-MB-231 xenograft and patient-derived tumor xenograft by inhibiting thioredoxin redox activity. We, for the first time, showed that AF increased CD8+Ve T-cell tumor infiltration in vivo and upregulated immune checkpoint PD-L1 expression in an ERK1/2-MYC-dependent manner. Moreover, combination of AF with anti-PD-L1 antibody synergistically impaired the growth of 4T1.2 primary tumors. Our data provide a novel therapeutic strategy using AF in combination with anti-PD-L1 antibody that warrants further clinical investigation for TNBC patients. 相似文献
10.
Nimrat Chatterjee Sanjay D'Souza Mohammad Shabab Cynthia A. Harris Gerard J. Hilinski Gregory L. Verdine Graham C. Walker 《Environmental and molecular mutagenesis》2020,61(8):830-836
Stapled α-helical RIR (Rev1-interacting region) peptides of DNA POL κ bind more effectively to the RIR-interface of the C-terminal recruitment domain of the translesion synthesis DNA polymerase Rev1 than unstapled peptide. The tightest-binding stapled peptide translocates into cells and enhances the cytotoxicity of DNA damaging agents while reducing mutagenesis. Drugs with these characteristics could potentially serve as adjuvants to improve chemotherapy and reduce acquired resistance by inhibiting Rev1-dependent mutagenic translesion synthesis. 相似文献