收费全文 | 13487篇 |
免费 | 1052篇 |
国内免费 | 29篇 |
耳鼻咽喉 | 198篇 |
儿科学 | 331篇 |
妇产科学 | 226篇 |
基础医学 | 1701篇 |
口腔科学 | 324篇 |
临床医学 | 1230篇 |
内科学 | 2762篇 |
皮肤病学 | 241篇 |
神经病学 | 1309篇 |
特种医学 | 526篇 |
外科学 | 2303篇 |
综合类 | 217篇 |
一般理论 | 13篇 |
预防医学 | 1017篇 |
眼科学 | 383篇 |
药学 | 777篇 |
中国医学 | 7篇 |
肿瘤学 | 1003篇 |
2023年 | 44篇 |
2021年 | 167篇 |
2020年 | 125篇 |
2019年 | 215篇 |
2018年 | 235篇 |
2017年 | 173篇 |
2016年 | 186篇 |
2015年 | 274篇 |
2014年 | 359篇 |
2013年 | 649篇 |
2012年 | 777篇 |
2011年 | 883篇 |
2010年 | 454篇 |
2009年 | 428篇 |
2008年 | 876篇 |
2007年 | 940篇 |
2006年 | 907篇 |
2005年 | 968篇 |
2004年 | 866篇 |
2003年 | 841篇 |
2002年 | 839篇 |
2001年 | 141篇 |
2000年 | 101篇 |
1999年 | 114篇 |
1998年 | 152篇 |
1997年 | 119篇 |
1996年 | 111篇 |
1995年 | 124篇 |
1994年 | 101篇 |
1993年 | 106篇 |
1992年 | 80篇 |
1991年 | 86篇 |
1990年 | 72篇 |
1989年 | 67篇 |
1988年 | 84篇 |
1987年 | 56篇 |
1986年 | 71篇 |
1985年 | 61篇 |
1984年 | 91篇 |
1983年 | 90篇 |
1982年 | 115篇 |
1981年 | 112篇 |
1980年 | 116篇 |
1979年 | 65篇 |
1978年 | 69篇 |
1977年 | 78篇 |
1976年 | 68篇 |
1975年 | 56篇 |
1974年 | 59篇 |
1973年 | 65篇 |
Background
There is evidence linking metformin to improved prostate cancer–related outcomes.Patients and Methods
Twenty-five men with metastatic castration-resistant prostate cancer and prostate-specific antigen (PSA) progression while receiving treatment with abiraterone from 3 Swiss centers were included in this single-arm phase 2 trial between November 2013 and September 2016. Metformin was added to abiraterone continuously at 1000 mg twice daily in uninterrupted 4-week cycles. The primary end point was the absence of disease progression at 12 weeks (PFS12). The Fleming single-stage design was applied. With a 5% significance level and 80% power, 25 patients were required to test PFS12 ≤ 15% (H0) compared to ≥ 35% (H1). Secondary end points included toxicity and safety issues. The study was registered at ClinicalTrials.gov (NCT01677897).Results
The primary end point PFS12 was 12% (3 of 25 patients) (95% confidence interval, 3-31). Most patients had PSA progression, almost half had radiographic progression, but only 1 patient had symptomatic progression. Eleven (44%) of 25 patients had grade 1 and 2 patients each grade 2 (8%) or grade 3 (8%) gastrointestinal toxicity (nausea, diarrhea, loss of appetite). One patient discontinued treatment at week 5 because of intolerable grade 3 diarrhea.Conclusion
The addition of metformin to abiraterone for patients with metastatic castration-resistant prostate cancer and PSA progression while receiving abiraterone therapy does not affect further progression and has no meaningful clinical benefit. A higher-than-expected gastrointestinal toxicity attributed to metformin was observed. 相似文献Areas covered: This review focuses on current treatments and the future outlook for allergic rhinitis. Pharmacotherapy includes mast cell stabilizers, antihistamines, glucocorticosteroids (GCSs), leukotriene receptor antagonists, and nasal decongestants. Nasal GCSs are currently regarded as the most effective treatment and are considered first-line therapy together with non-sedating antihistamines. The new formulation MP29-02 combines the nasal GCS fluticasone propionate with azelastine in one single spray and has achieved greater improvements than those under monotherapy with modern GCSs or antihistamines. Furthermore, this review discusses allergen immunotherapy alone and in combination with modern monoclonal antibodies.
Expert opinion: Despite the variety of medications for allergic rhinitis, ranging from general symptomatic agents like GCSs or decongestants, to more specific ones like histamine receptor or leukotriene blockers, to causal therapy like immunotherapy, many patients still experience treatment failures or unsatisfactory results. The ultimate goal may be to endotype every downstream pathway separately in order to offer patients individualized, targeted therapy with specific antibodies against the respective pathway. 相似文献