全文获取类型
收费全文 | 382篇 |
免费 | 23篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 16篇 |
妇产科学 | 9篇 |
基础医学 | 50篇 |
临床医学 | 42篇 |
内科学 | 61篇 |
皮肤病学 | 9篇 |
神经病学 | 45篇 |
特种医学 | 11篇 |
外科学 | 72篇 |
综合类 | 5篇 |
预防医学 | 34篇 |
药学 | 14篇 |
肿瘤学 | 34篇 |
出版年
2023年 | 3篇 |
2022年 | 7篇 |
2021年 | 22篇 |
2020年 | 9篇 |
2019年 | 29篇 |
2018年 | 19篇 |
2017年 | 17篇 |
2016年 | 6篇 |
2015年 | 7篇 |
2014年 | 15篇 |
2013年 | 12篇 |
2012年 | 21篇 |
2011年 | 27篇 |
2010年 | 14篇 |
2009年 | 6篇 |
2008年 | 11篇 |
2007年 | 22篇 |
2006年 | 11篇 |
2005年 | 15篇 |
2004年 | 13篇 |
2003年 | 17篇 |
2002年 | 10篇 |
2001年 | 2篇 |
1999年 | 4篇 |
1998年 | 3篇 |
1996年 | 2篇 |
1991年 | 3篇 |
1990年 | 3篇 |
1989年 | 2篇 |
1988年 | 4篇 |
1987年 | 3篇 |
1986年 | 5篇 |
1985年 | 3篇 |
1984年 | 3篇 |
1969年 | 3篇 |
1967年 | 2篇 |
1965年 | 2篇 |
1944年 | 2篇 |
1941年 | 2篇 |
1940年 | 2篇 |
1927年 | 3篇 |
1926年 | 3篇 |
1925年 | 1篇 |
1922年 | 3篇 |
1911年 | 1篇 |
1908年 | 1篇 |
1896年 | 1篇 |
1895年 | 1篇 |
1892年 | 1篇 |
1890年 | 1篇 |
排序方式: 共有405条查询结果,搜索用时 15 毫秒
1.
Nuray
. Kanbur Eudice Goldberg Leora Pinhas Robert M. Hamilton Robin Clegg Debra K. Katzman 《The International journal of eating disorders》2009,42(6):575-578
Anorexia nervosa (AN) can cause both functional and structural cardiac complications, including a variety of different conduction abnormalities. This is the first case report of symptomatic diurnal second‐degree atrioventricular (AV) block (Mobitz Type I) in an adolescent with AN. We present a 12‐year‐old girl with AN, restrictor sub‐type who reported cardiac symptoms during weight gain, at the time of the initial diagnosis of AV block. Second‐degree AV block (Mobitz Type I) is discussed as a possible complication of the AN, as well as being an intrinsic conduction system disease. © 2009 by Wiley Periodicals, Inc. Int J Eat Disord 2009 相似文献
2.
Sher Geoffrey; Feinman Michael; Zouves Christo; Kuttner Gordon; Maassarani Ghanima; Salem Rifaat; Matzner William; Ching Wendell; Chong Penny 《Human reproduction (Oxford, England)》1994,9(12):2278-2283
This study was undertaken to explore whether intervention withheparin and aspirin (H/A) in selected patients undergoing in-vitrofertilization (TVF) and embryo transfer could improve fecundityrates. Specifically, it explored the possibility that womendiagnosed with organic pelvic disease who demonstrated antiphospholipidantibodies (APA) could benefit from H/A administration in asimilar manner to that used in patients with recurrent pregnancyloss. We used an enzymelinked immunosorbent assay forsix different phospholipids to identify patients who expressedAPA before they underwent IVF/embryo transfer. This study wasconfined to the first IVF/embryo transfer cycle that followedassessment of APA status and accordingly, the number of IVF/embryotransfer cycles corresponds with the number of patients treated.APA seropositive patients were treated with aspirin, 81 mg orallyq.d., and heparin 5000 IU s.c. b.i.d., beginning on day 1 ofcontrolled ovarian stimulation. The endpoint for success wasa live birth or an ultrasound confirming fetal cardiac activity(a viable pregnancy). The prevalence of APA in patients diagnosedwith organic pelvic disease (53%) was much higher than in thosewithout female pathology (14%). The administration of H/A toAPA seropositive patients significantly (P < 0.05) improvedthe viable pregnancy rate (49%) compared to the untreated APAseropositive group (16%). The viable pregnancy rate for APAseropositive women treated with H/A was also significantly (P< 0.001) higher than for untreated APA seronegative patients(27%). We conclude that all women undergoing IVF/embryo transfershould be tested for APA prior to initiating ovarian stimulation,and those with APA seropositivity should be treated with H/A. 相似文献
3.
Kelvin L Chou Maria L Moro-De-Casillas Melissa M Amick Leora L Borek Joseph H Friedman 《Movement disorders》2007,22(3):411-414
We examined the relationship between testosterone levels, violent dreams, and REM sleep behavior disorder (RBD) in 31 men with Parkinson's disease (PD): 12 with clinical RBD and 19 without. All PD patients with clinical RBD experienced violent dreams, but none of the 19 non-RBD patients reported violent dreams. While dream content appears to be more aggressive in PD patients with clinical RBD, the presence of violent dreams or clinical RBD is not associated with testosterone levels in men with PD. 相似文献
4.
Ermert M Kuttner D Eisenhardt N Dierkes C Seeger W Ermert L 《Laboratory investigation; a journal of technical methods and pathology》2003,83(3):333-347
Mitogen-activated protein kinases (MAPKs) are part of an intracellular signaling machinery consisting of three known distinct pathways, each leading to activation of a different protein kinase: p38, ERK (extracellular signal-regulated kinase), or JNK (c-Jun N-terminal kinase). We investigated the role of the p38 MAPK pathway in the phenomenon of lung endotoxin "priming": incubation of perfused rat lungs with lipopolysaccharide (LPS) for 2 hours results in drastically enhanced cyclooxygenase-2-dependent and thromboxane synthase-dependent vasoconstriction and bronchoconstriction, including edema formation in response to a second inflammatory stimulus, such as arachidonic acid application. Two unrelated selective inhibitors of p38 (SB203580 and SC-68376) dose dependently suppressed the arachidonic acid-induced pulmonary artery pressor response, edema formation, and bronchoconstrictor response in both control lungs and lungs that underwent preceding endotoxin priming. In parallel, thromboxane, but not prostacyclin, released into the lung perfusate was dose dependently inhibited. Using immunohistochemical techniques in combination with quantitative microdensitometry, p38 was detected in nearly all cell types in control lungs, whereas the activated form p-p38 was only expressed in certain cell types, eg, bronchial epithelial cells, endothelial cells, alveolar macrophages, and vascular smooth muscle cells (SMC) of small vessels. In response to endotoxin, p-p38 expression was additionally observed in septal cells, bronchial SMC, and vascular SMC of larger pulmonary vessels and was increased in most other cell types including small-vessel SMC. We conclude that both immunolocalization of p38 activity and pharmacologic interventions support a strong role of the p38 MAPK pathway in establishing an active cyclooxygenase-2/thromboxane synthase axis in vascular and bronchial SMC, with up-regulation of this signaling cascade occurring in LPS priming and being responsible for enhanced pulmonary artery pressor response, edema formation, and bronchoconstriction. Moreover, LPS induces or increases phosphorylation of p38 in other lung cell types. The physiologic consequences of these events remain to be established. 相似文献
5.
Norman E. Rosenthal Leora N. Rosenthal Frank Stallone Joseph Fleiss David L. Dunner Ronald R. Fieve 《Journal of affective disorders》1979,1(4):237-245
Sixty-six bipolar I lithium clinic patients were studied for a history of psychotic symptoms at some time during the course of their illness. Agreement between different sources of information was calculated, and the patient population was divided into psychotic and non-psychotic subgroups. Probability of remaining well on lithium for the different subgroups was analyzed by the life table method. Psychosis during mania appeared to be associated with especially good early lithium prophylaxis. 相似文献
6.
According to attribution theory, controllability, locus, and stability are important dimensions underlying causal explanations. The extent to which these theoretical dimensions underlie lay explanations for physical symptoms is unclear. Accordingly, in this study, attributes relevant to the lay public were empirically derived using a multidimensional scaling (MDS) procedure. Undergraduates (N=194) provided similarity judgments for 18 potential causes of physical discomfort. The MDS analysis yielded a three-dimensional solution. The first dimension captured the distinction between physical and nonphysical causes. The second dimension distinguished either variable versus stable causes or those that are controllable versus uncontrollable by health care professionals. The third dimension differentiated causes under low versus high personal control. These findings empirically confirm the theoretically proposed dimensions of personal control and stability and suggest the utility of considering the physical/nonphysical and controllability by health care professional distinctions in future work on attributions in the health domain. 相似文献
7.
8.
9.
Gadi Horev M.D. Leora Kornreich M.D. Herzeliah Hadar M.D. Kalman Katz M.D. 《Skeletal radiology》1991,20(7):479-482
Children suffering from Gaucher's disease were examined by magnetic resonance imaging (MRI) during a characteristic episode of bone crisis. An unexpectedly high intramedullary as well as subperiosteal signal was observed on both the T1 and T2-weighted sequences in 5 patients, suggesting a subacute hemorrhage or hematoma. It is conceivable that such a painful hemorrhage is an important component of the bone crisis phenomenon. Furthermore, in these cases this is a specific sign which may enable differentiation of bone crises from other types of bone pain associated with Gaucher's disease. 相似文献
10.
Rosen LN 《Violence against women》2007,13(9):945-960
This study involves a test of the cultural spillover hypothesis through a state-level analysis of the relationship between rape rates and the proportion of military personnel in the population. A statistically significant correlation not predicted by this hypothesis was found between rape rates and the proportion of Air Force personnel in the population. Further exploration revealed that this was largely because of the high correlation between the Air Force and the Indian population. Multivariate analyses revealed that the proportion of Indian women in the population was the main predictor of rape rates. Per capita alcohol consumption was also found to be positively correlated with both rape rates and Air Force personnel but was not significantly related to rape in the multivariate analysis. 相似文献