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排序方式: 共有563条查询结果,搜索用时 31 毫秒
1.
HSS Journal ® - This article is a critical analysis of a study, “Minimally Manipulated Bone Marrow Concentrate Compared with Microfracture Treatment of Full-Thickness Chondral Defects: A... 相似文献
2.
Ana M. Calvo‐Maroto Rafael J. Perez‐Cambrodi Santiago Garcia‐Lazaro Teresa Ferrer‐Blasco Alejandro Cerviño 《Journal of Diabetes》2016,8(5):619-628
Diabetes mellitus is a metabolic disease with a considerable impact on healthcare owing to its increased prevalence and high mortality rate. Structural, morphological, and physiological changes in each of the ocular components have been described in detail. Autofluorescence has been described as a good indicator of metabolic activity. The aim of the present review is to provide an overview of ocular endogenous fluorophores in the cornea, the crystalline lens, and the retinal pigment epithelium, the effects of diabetes mellitus and therefore the potential of autofluorescence assessment for screening and monitoring changes in diabetic patients. 相似文献
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Carine Salliot Amélie Denis Emmanuelle Dernis Vincent Andre Aleth Perdriger Jean-David Albert Saloua Mammou Mraghni Isabelle Griffoul-Espitalier Mohamed Hamidou Benoit Le Goff Sandrine Jousse Joulin Thierry Marhadour Christophe Richez Nicolas Poursac Estebaliz Lazaro Stéphanie Rist Anca Corondan Clara Quinten Emilie Ducourau 《Joint, bone, spine : revue du rhumatisme》2018,85(6):741-745
Objectives
The aims of this study in SLE population were (1) to describe ultrasonography (US) joint abnormalities, (2) to estimate the reliability of clinical swollen joint count (C-SJC) and SLEDAI (C-SLEDAI) versus US-SJC and US-SLEDAI scores, (3) to highlight specific patterns of lupus patients with Power Doppler (PD) abnormalities.Method
For this cross-sectional multicenter study, 151 consecutive adult SLE patients were recruited. Evaluation included a clinical standardized joint assessment, B-mode and PD US of 40 joints and 26 tendons blinded for clinical examination. Reliability and agreement between clinical and B-mode US were calculated using the intraclass correlation coefficients (ICC [95% Confidence Interval]).Results
We found a very high frequency of subclinical US abnormalities in asymptomatic patients: 85% of patients without joint symptoms had at least 1 US abnormality. Among them 46 patients (87%) had a history of joint involvement. The most frequent abnormalities were joint effusmaions (108 patients), synovial hypertrophy (SH, 109 patients) and synovitis (61 patients). Joint or tendon PD signal (grade > 1) was found in 44% of patients (67/151). Synovitis were mainly located especially on MCPs and wrists. Even if reliability between clinical and grey-scale US SJC assessments was poor, reliability between clinical and US SLEDAI was good. Comparison between SLE patients with and without PD signal did not show any specific SLE pattern.Conclusion
US may be useful to assess joint involvement in SLE patients but did not significantly change SLEDAI score. 相似文献5.
6.
Marschall B. Berkes Joshua S. Dines Jacqueline F. Birnbaum Lionel E. Lazaro Tristan C. Lorich Milton T. M. Little Joseph T. Nguyen Dean G. Lorich 《HSS journal》2015,11(3):192-197
Background
Convention dictates that an axillary view be obtained when evaluating proximal humerus fractures (PHF). However, the axillary view is frequently omitted because of pain and technical considerations. Furthermore, its diagnostic utility is unclear in this setting.Questions/Purposes
The purpose of this study was to (1) determine the rate of obtaining an adequate axillary X-ray and complete shoulder series at a level I trauma center, (2) understand the cost of ordering and attempting an axillary radiograph, and (3) determine if axillary radiographs influence the management of PHF.Patients and Methods
PHF treated between 2009 and 2011 that were ordered for an AP, scapular Y, and axillary view was identified. The types of radiographs actually obtained were recorded. The cost of obtaining three views and a single view of the shoulder with X-ray was determined. Lastly, three surgeons reviewed 42 PHF, both with and without an axillary view (AV), and treatment recommendations were compared.Results
30% of PHF in this series had an adequate axillary view, and 14% received a complete trauma series. No factors could be identified that were associated with successfully obtaining an axillary view. Reviewers demonstrated substantial intraobserver reliability (κ = 0.759–0.808) regarding treatment recommendations for PHF with and without the axillary view. The addition of the AV had minimal influence on treatment recommendations.Conclusion
Considering that the axillary view for PHF is painful, labor-intensive, costly, and does not appear to provide additional diagnostic value, orthopedic surgeons can consider foregoing the use of the axillary view when evaluating and treating PHF, particularly if other advanced imaging is utilized.Electronic supplementary material
The online version of this article (doi:10.1007/s11420-015-9445-9) contains supplementary material, which is available to authorized users. 相似文献7.
8.
目的:由于技术原理的限制,目前尚不能对所有的HLA等位基因进行严格的区分,特别是以往没有发现的新基因序列只能通过测序的方法解决,然而,当遇到等位基因杂合时,测序给出的结果仍然无法确认新的序列改变发生在等位基因的哪一侧,这时需要用分子生物学方法分离杂合子然后进行测序才能确定新的基因序列。采用基因克隆方法确认HLA新等位基因。
方法:实验于2006-01/05在河南省红十字血液中心HLA实验室,美国海军骨髓库HLA实验室完成。造血干细胞血样由中华骨髓库提供。采用荧光微珠HLA分型方法对中华骨髓库捐献者血样进行HLA分型检测,无法给出确切结果的摸棱两可结果标本用基因克隆(TOPO TA Cloning)、DNA测序的方法确认新的HLA基因序列。
结果:通过克隆分离杂合等位基因,再进行测序确认发现新的序列与B^*3709相比,出现4个核苷酸改变:1.355nt C〉A,2.363nt C〉G,3.412nt G〉A,4.477ntC〉G,而且均发生在H哺B基因外显子3(exon3)。4处改变引起氨基酸编码改变:①编码95CTC〉ATC,氨基酸改变L〉1(亮氨酸〉异亮氨酸)。②97AGC〉AGG.S〉R(丝氨酸〉精氨酸)。③114GAC〉AACD〉N(天门冬氨酸〉天冬酰胺)。(9135GCC〉GCGA=A无氨基酸改变。
结论:①新的基因序列已经在GenBnak注册,被WHO的HLA因子命名委员会得到正式命名为HLA-B^*3712基因。②基因克隆是确认HLA新基因的根本方法。 相似文献
9.
Durez Patrick Pavelka Karel Lazaro Maria Alicia Garcia-Kutzbach Abraham Moots Robert J. Amital Howard Govoni Marinella Vastesaeger Nathan 《Clinical rheumatology》2018,37(7):2017-2018
Clinical Rheumatology - The original publication contains two areas which require correcting. None of these errors change the results or conclusions of the article, but the authors wish to... 相似文献
10.
N. Gensous L. Doassans-Comby E. Lazaro P. Duffau 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》2017,38(6):358-367