全文获取类型
收费全文 | 19338篇 |
免费 | 1618篇 |
国内免费 | 37篇 |
专业分类
耳鼻咽喉 | 126篇 |
儿科学 | 701篇 |
妇产科学 | 487篇 |
基础医学 | 2409篇 |
口腔科学 | 475篇 |
临床医学 | 2959篇 |
内科学 | 3538篇 |
皮肤病学 | 189篇 |
神经病学 | 1518篇 |
特种医学 | 546篇 |
外科学 | 2499篇 |
综合类 | 457篇 |
一般理论 | 20篇 |
预防医学 | 2363篇 |
眼科学 | 219篇 |
药学 | 1163篇 |
中国医学 | 9篇 |
肿瘤学 | 1315篇 |
出版年
2021年 | 270篇 |
2020年 | 181篇 |
2019年 | 282篇 |
2018年 | 359篇 |
2017年 | 275篇 |
2016年 | 288篇 |
2015年 | 338篇 |
2014年 | 485篇 |
2013年 | 728篇 |
2012年 | 1077篇 |
2011年 | 1192篇 |
2010年 | 616篇 |
2009年 | 573篇 |
2008年 | 1003篇 |
2007年 | 1150篇 |
2006年 | 1043篇 |
2005年 | 1041篇 |
2004年 | 981篇 |
2003年 | 896篇 |
2002年 | 897篇 |
2001年 | 445篇 |
2000年 | 517篇 |
1999年 | 469篇 |
1998年 | 180篇 |
1997年 | 161篇 |
1996年 | 181篇 |
1995年 | 194篇 |
1994年 | 168篇 |
1993年 | 153篇 |
1992年 | 340篇 |
1991年 | 342篇 |
1990年 | 356篇 |
1989年 | 299篇 |
1988年 | 265篇 |
1987年 | 261篇 |
1986年 | 242篇 |
1985年 | 252篇 |
1984年 | 184篇 |
1983年 | 148篇 |
1982年 | 105篇 |
1980年 | 109篇 |
1979年 | 155篇 |
1978年 | 127篇 |
1977年 | 102篇 |
1976年 | 101篇 |
1974年 | 124篇 |
1973年 | 116篇 |
1972年 | 117篇 |
1971年 | 115篇 |
1970年 | 104篇 |
排序方式: 共有10000条查询结果,搜索用时 390 毫秒
1.
Hannah S. Bell Funmi Odumosu Anna C. Martinez-Hume Heather A. Howard 《Medical anthropology》2019,38(3):224-238
Racial/ethnic identity is contingent and arbitrary, yet it is commonly used to evaluate disease risk and treatment response. Drawing on open-ended interviews with patients and clinicians in two US clinics, we explore how racialized risk is conceptualized and how it impacts patient care and experience. We found that racial/ethnic risk was a common but poorly defined construct for both patients and clinicians, who intermingled concepts of genetics, biology, behavior, and culture, while disregarding historical or structural context. We argue that racializing risk embodies social power in marked and unmarked bodies, reinforcing inequality along racial lines and undermining equitable health care. 相似文献
2.
3.
4.
5.
6.
Béla Nagy Zsolt Bene Zsolt Fejes Sonya L. Heltshe David Reid Nicola J. Ronan Yvonne McCarthy Daniel Smith Attila Nagy Elizabeth Joseloff György Balla János Kappelmayer Milan Macek Scott C. Bell Barry J. Plant Margarida D. Amaral István Balogh 《Journal of cystic fibrosis》2019,18(2):271-277
Background
We have recently shown that human epididymis protein 4 (HE4) levels correlate with the severity of cystic fibrosis (CF) lung disease. However, there are no data on how HE4 levels alter in patients receiving CFTR modulating therapy.Methods
In this retrospective clinical study, 3 independent CF patient cohorts (US-American: 29, Australian: 12 and Irish: 19 cases) were enrolled carrying at least one Class III CFTR CF-causing mutation (p.Gly551Asp) and being treated with CFTR potentiator ivacaftor. Plasma HE4 was measured by immunoassay before treatment (baseline) and 1–6?months after commencement of ivacaftor, and were correlated with FEV1 (% predicted), sweat chloride, C-reactive protein (CRP) and body mass index (BMI).Results
After 1?month of therapy, HE4 levels were significantly lower than at baseline and remained decreased up to 6?months. A significant inverse correlation between absolute and delta values of HE4 and FEV1 (r?=??0.5376; P?<?.001 and r?=??0.3285; P?<?.001), was retrospectively observed in pooled groups, including an independent association of HE4 with FEV1 by multiple regression analysis (β?=??0.57, P?=?.019). Substantial area under the receiver operating characteristic curve (ROC-AUC) value was determined for HE4 when 7% mean change of FEV1 (0.722 [95% CI 0.581–0.863]; P?=?.029) were used as classifier, especially in the first 2?months of treatment (0.806 [95% CI 0.665–0.947]; P?<?.001).Conclusions
This study shows that plasma HE4 levels inversely correlate with lung function improvement in CF patients receiving ivacaftor. Overall, this potential biomarker may be of value for routine clinical and laboratory follow-up of CFTR modulating therapy. 相似文献7.
8.
Esther M. John Amanda I. Phipps Lisa M. Hines Jocelyn Koo Sue A. Ingles Kathy B. Baumgartner Martha L. Slattery Anna H. Wu 《International journal of cancer. Journal international du cancer》2020,147(7):1808-1822
We pooled multiethnic data from four population-based studies and examined associations of menstrual and reproductive characteristics with breast cancer (BC) risk by tumor hormone receptor (HR) status [defined by estrogen receptor (ER) and progesterone receptor (PR)]. We estimated odds ratios and 95% confidence intervals using multivariable logistic regression, stratified by age (<50, ≥50 years) and ethnicity, for 5,186 HR+ (ER+ or PR+) cases, 1,365 HR− (ER− and PR−) cases and 7,480 controls. For HR+ BC, later menarche and earlier menopause were associated with lower risk in non-Hispanic whites (NHWs) and Hispanics, and higher parity and longer breast-feeding were associated with lower risk in Hispanics and Asian Americans, and suggestively in NHWs. Positive associations with later first full-term pregnancy (FTP), longer interval between menarche and first FTP and shorter time since last FTP were limited to younger Hispanics and Asian Americans. Except for nulliparity, reproductive characteristics were not associated with risk in African Americans. For HR− BC, lower risk was associated with later menarche, except in African Americans and older Asian Americans and with longer breast-feeding in Hispanics and Asian Americans only. In younger African Americans, HR− BC risk associated with higher parity (≥3 vs. 1 FTP) was increased fourfold in women who never breast-fed, but not in those with a breast-feeding history, suggesting that breast-feeding may mitigate the adverse effect of higher parity in younger African American women. Further work needs to evaluate why menstrual and reproductive risk factors vary in importance according to age and ethnicity. 相似文献
9.
Beeler Michael B. Malone Timothy R. Boulter Jason H. Bell Randy S. Rosner Michael K. Cook Glen A. 《Clinical autonomic research》2020,30(2):177-179
Clinical Autonomic Research - 相似文献
10.
Jane Koch Lucie M. Ramjan Bronwyn Everett Anna Maceri Kate Bell Yenna Salamonson 《Journal of clinical nursing》2020,29(5-6):863-871