Comparison of Ileal Digested Production of Parental Rice and Rice Genetically Modified With Cowpeas Trypsin Inhibitor

INTRODUCTION With the rapid development of genetically modified foods in the world, the safety assessment of these novel foods is becoming the first task for governments, scientists, and consumers. At the same time, nutritional assessment is an important …     

Impact of Chronic Obstructive Pulmonary Disease on Procedural Outcomes and Quality of Life in Patients with Atrial Fibrillation Undergoing Catheter Ablation

Impact of COPD on Atrial Fibrillation Ablation. Background : Chronic obstructive pulmonary disease (COPD) is a risk factor for atrial fibrillation (AF). The aim of this study was to investigate the impact of COPD on outcomes of catheter ablation in patients with AF in terms of recurrence and quality of life (QoL). Methods : In this prospective study, 550 consecutive patients with symptomatic, medication‐refractory AF underwent first catheter ablation. Patients were classified into those with COPD (group 1, n = 54) and those without COPD (group 2, n = 496). Patients were followed up for atrial tachyarrhythmia (ATa) recurrence for at least 24 months. The Medical Outcomes Study SF‐36 Health Survey was used to assess QoL at baseline and 24 months after ablation. Results : After a single ablation, 24 patients in group 1 (44.4%) and 142 in group 2 (28.6%) had ATa recurrence during a mean follow‐up of 31.4 ± 4.8 months (P = 0.016). The second ablation was performed in 19 patients (35.2%) from group 1 and in 109 patients (22.0%) from group 2 (P = 0.029). Multivariate logistic analysis showed that nonparoxysmal AF (P = 0.013, OR = 1.767, 95% CI: 1.129–2.765) as well as the presence of COPD (P = 0.029, OR = 1.951, 95% CI: 1.070–3.557) was the independent predictor for higher ATa recurrence. Moreover, patients in group 1 had significantly lower baseline scores on all SF‐36 Health Survey subscales. At 24‐month follow‐up, both mental component summary and physical component summary scores improved markedly in group 1 and 2. Conclusions : Although the presence of COPD predicted higher recurrence after single‐catheter ablation in AF patients, significant improvements in QoL were observed in the postablation COPD population. (J Cardiovasc Electrophysiol, Vol. 24, pp. 148‐154, February 2013)     

超声引导持续腹腔灌洗引流在急性重症胰腺炎治疗中的应用

目的探讨超声引导下腹腔置管持续灌洗引流在急性重症胰腺炎(SAP)治疗中的作用。方法治疗组:选择20例SAP住院患者,其中合并胆系结石13例,在综合性非手术治疗的同时,住院当天行超声引导下腹腔置管持续灌洗引流术。对照组:选择同时期SAP住院患者25例,4例行外科手术治疗,21例行与治疗组相同的非手术治疗。两组患者的合并症构成比、平均年龄、住院当天的症状、体温、心率、白细胞计数和血、尿淀粉酶各项临床观察及检测指标比较,差异无显著性(P>0.05)。以患者住院第5天的症状、体温、心率、白细胞计数和血、尿淀粉酶及平均住院日为疗效观察指标,并进行医学统计学处理及分析。结果治疗后第5天,治疗组患者体温、心率、白细胞计数和血、尿淀粉酶明显下降,与对照组比较差异有非常显著性(P<0.01),治疗组平均住院日(26.8±13.2)d与对照组(29.6±13.5)d比较也有显著性差异(P<0.05)。结论超声引导持续腹腔灌洗引流术具有安全、便捷、创伤小,效果显著的优点,能使SAP患者体温、心率、白细胞计数和血、尿淀粉酶等临床观察及检测指标迅速恢复,腹痛减轻,缩短住院日,在SAP治疗中具有重要意义。     

手足口病患儿外周血单核细胞亚群的研究

目的：探讨未经治疗和随访1、3、5 d手足口患儿外周血单核细胞亚群的变化。方法流式细胞仪检测104例未经治疗手足口患儿（包括阴性患儿62例,EV71阳性患儿37例,CVA16阳性患儿5例）和随访1、3、5 d的患儿外周血单核细胞CD14highCD16-亚群、CD14highCD16＋亚群和CD14lowCD16＋亚群。结果与健康儿童组相比,手足口患儿CD14highCD16＋单核细胞亚群所占总单核细胞比例明显升高（t =4.092,P ＜0.001）;CD14highCD16-亚群比例明显降低。阴性、EV71型、CVA16型患儿之间CD14highCD16-亚群、CD14highCD16＋亚群和CD14lowCD16＋亚群差异均无统计学意义。结论未经治疗的手足口患儿外周血单核细胞亚群的变化可能与EV71及CVA16病毒的持续感染有关,与病毒种类相关性不明显。     

Video-Assisted Thoracoscopic Sympathectomy for Congenital Long QT Syndromes

LI, J., et al .: Video-Assisted Thoracoscopic Sympathectomy for Congenital Long QT Syndromes. The feasibility, safety, and effectiveness of video-assisted thoracoscopic sympathectomy (VATS) for congenital long QT syndrome were assessed in four patients who had frequent syncopal events before the surgeries. Under general anaesthesia, the pleural cavity was entered via two small incisions in the left third and fifth intercostal spaces at the mid-axillary line. The left thoracic sympathetic chain was identified and resected from T2-T5. The lower one third of the left stellate ganglion was also resected. VATS resulted in a significant shortening in corrected QT intervals (QTc) in three patients, the average QTc of the four patients immediately before and after VATS was   538 ± 76   and   512 ± 57 ms   , respectively   (P = 0.047)   . The heart rate remained unchanged after the VATS (   67 ± 4   vs   69 ± 4 beats/min, P > 0.05   ). There were no major perioperative complications apart from mild ptosis of the left upper eyelid in one patient who recovered in the following days. There was no recurrence in syncopal events after a 3-month follow-up. VATS is a safe and effective technique for left cardiac sympathectomy in patients with congenital long QT syndromes. (PACE 2003; 26[Pt. I]:870–873)     

Congenital leukaemia with a mixed phenotype of megakaryoblasts and erythroblasts: a case report and characterization of the blasts

We present a congenital leukaemia with a mixed phenotype of megakaryoblasts and erythroblasts. A newborn male with exopthalmus and multiple skin nodules, had bone marrow blasts which expressed CD41b, CD42b, glycophorin-A and haemoglobin, but monocyte or lymphoid markers were negative. The patient achieved a complete remission with chemotherapy. Blasts cultured for a few months expressed erythroid markers but lost the megakaryocytic phenotype, although addition of phorbol ester induced the latter phenotype. Spontaneous colony formation was observed in semi-solid culture and the number of colonies was increased by erythropoietin. Detailed studies further indicated the heterogeneity of congenital leukaemia.     

171例慢性乙型肝炎病毒感染者临床与肝组织病理分析

目的:观察171例HBV DNA阳性的慢性乙型肝炎病毒(HBV)感染者临床检测指标与肝脏组织病理的关系.方法:将171例患者分为4组,A组丙氨酸氨基转移酶(ALT)≤0.5 ×ULN(正常值上限),B组0.5 ×ULN＜ALT≤1×ULN,C组1×ULN＜ ALT≤2×ULN,D组2×ULN＜ ALT≤5 × ULN,观察各组患者肝脏炎症分级(G)和纤维化分期(S)的差异,进一步分析各组炎症分级和纤维化分期与其他肝脏生化学指标如天门冬氨酸氨基转移酶(AST)、血小板(PLT).及肝纤维化模型(APRI,以AST/PLT比值的统计量作为数字化模型)的关系.结果:A组25％患者肝组织炎症为G2,B组和C组分别有16.4％、49.2％患者肝组织炎症分级为G2～G3,不同ALT组间肝组织炎症分级的差异有显著性意义(P＜0.05),随着ALT水平升高,肝组织G2～G3检出比例增加;171例患者不同肝组织炎症分级组,球蛋白(Glo)、AST、γ-谷氨酰转肽酶(GGT)、PLT、APRI的差异均有显著性意义(P＜0.05);不同肝组织纤维化分期组,年龄、HBeAg状态、白蛋白(Alb)、AST、GGT、PLT、HBV DNA、APRI的差异均有显著性意义(P＜0.05),其中随着纤维化程度进展,AST、APRI值逐渐升高,Alb、PLT逐渐下降.结论:HBV DNA阳性的慢性HBV感染者,即使ALT正常,仍有不同程度的肝组织炎症和纤维化改变,需综合观察年龄、AST、GGT、APRI、HBeAg状态和HBV DNA水平,必要时建议患者行肝脏穿刺病理检查,以准确了解肝脏疾病进展.     

Human herpesvirus-6-associated exanthema in a patient with acute lymphocytic leukaemia

We report the first case of human herpesvirus-6 (HHV-6) associated exanthema in a patient with acute lymphocytic leukaemia (ALL). We analysed DNA extracted from an exanthematous lesion using the polymerase chain reaction (PCR). DNA was positive for HHV-6 but negative for herpes simplex virus, varicella zoster virus, and cytomegalovirus. Immunohistochemical staining of the skin with monoclonal antibody against HHV-6 confirmed the infection. The possibility of HHV-6 infection should be considered when an atypical skin rash is seen in patients with ALL.