首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   27105篇
  免费   1558篇
  国内免费   234篇
耳鼻咽喉   232篇
儿科学   538篇
妇产科学   578篇
基础医学   2775篇
口腔科学   662篇
临床医学   1887篇
内科学   7745篇
皮肤病学   348篇
神经病学   2375篇
特种医学   1026篇
外科学   5133篇
综合类   54篇
一般理论   5篇
预防医学   974篇
眼科学   515篇
药学   1623篇
中国医学   55篇
肿瘤学   2372篇
  2023年   271篇
  2022年   232篇
  2021年   773篇
  2020年   577篇
  2019年   818篇
  2018年   988篇
  2017年   727篇
  2016年   850篇
  2015年   888篇
  2014年   1210篇
  2013年   1491篇
  2012年   2279篇
  2011年   2164篇
  2010年   1244篇
  2009年   1195篇
  2008年   1870篇
  2007年   1814篇
  2006年   1701篇
  2005年   1690篇
  2004年   1587篇
  2003年   1359篇
  2002年   1223篇
  2001年   120篇
  2000年   118篇
  1999年   150篇
  1998年   164篇
  1997年   137篇
  1996年   129篇
  1995年   149篇
  1994年   123篇
  1993年   119篇
  1992年   88篇
  1991年   55篇
  1990年   66篇
  1989年   50篇
  1988年   40篇
  1987年   36篇
  1986年   42篇
  1985年   38篇
  1984年   34篇
  1983年   33篇
  1982年   50篇
  1981年   28篇
  1980年   27篇
  1979年   18篇
  1978年   12篇
  1976年   11篇
  1975年   8篇
  1974年   12篇
  1933年   6篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Graefe's Archive for Clinical and Experimental Ophthalmology - To report a longitudinal analysis of specific optical coherence tomography (OCT) features in eyes with diabetic macular edema...  相似文献   
2.
Malignant melanoma (MM) is a highly aggressive neoplasm with a growing worldwide incidence. It is not uncommon that the disease is already metastatic at the time of the first diagnosis. Regional lymph nodes and skin are the first and most common metastatic sites, followed by distant visceral sites (lungs, liver, and central nervous system) and bone. In this clinical setting, fine-needle aspiration (FNA) often represents the first diagnostic approach. FNA is a useful tool to obtain a rapid and accurate diagnosis, in conjunction with ancillary techniques and molecular analysis, as recommended by recent guidelines. The aim of this review was to describe the cytomorphology, immunocytochemical tools, and molecular tools used for the diagnosis of MM metastases on FNA.  相似文献   
3.
4.
5.
6.
7.
8.
In 1952, renal cell carcinomas had been divided into 2 categories—clear cell or granular cell—depending upon their cytoplasmic staining characteristics. In the following years, the inventory of renal epithelial tumors has expanded by the addition of tumors named by their architectural pattern (i.e., papillary RCC, tubulocystic RCC), anatomic location (i.e., collecting duct carcinoma, renal medullary carcinoma), associated diseases (i.e., acquired cystic disease-associated RCCs). With the extensive application of molecular diagnostic techniques, it becomes possible to detect genetic distinctions between various types of renal neoplasm and discover new entities, otherwise misdiagnosed or diagnosed as unclassified RCC. Some tumors such as ALK rearrangement-associated RCC, MiT family translocation renal carcinomas, SDH-deficient renal cancer or FH-deficient RCC, are defined by their molecular characteristics. The most recent World Health Organization (WHO) classification of renal neoplasms account for more than 50 entities and provisional entities. New entities might be included in the upcoming WHO classification. The aim of this review is to summarise and discuss the newly acquired data and evidence on the clinical, pathological, molecular features and on the prognosis of new RCC entities, which will hopefully increase the awareness and the acceptance of these entities among clinicians and improve prognostication for individual patients.  相似文献   
9.
We investigated the occurrence and management of therapy‐related hematological disorders (tr‐HDs) in women with epithelial ovarian cancer (EOC) exposed to poly‐ADP‐ribose polymerase inhibitors (PARPi), after previous chemotherapy. We analyzed 130 consecutive EOC patients treated with PARPi at the European Institute of Oncology, Milan. In line with the literature, overall survival of the entire population was 37% at 5.5 years (89% were advanced stages). Cell blood counts were collected prior to start PARPi, at each new cycle and at monthly intervals. Patients displaying persistent and/or marked hematological abnormalities underwent bone marrow evaluation, with cytogenetic and molecular analysis. Nine patients (6,9%) developed tr‐HDs, after a median 22.8 months of PARPi exposure. Two patients died early and could not be treated. Two patients have no indication for active treatment and are presently under close hematological monitoring. Five patients underwent chemotherapy followed, in three cases, by allogeneic hematopoietic transplantation: three patients are in complete remission of their hematological and gynecological malignancies at 13, 19, and 25 months; the remaining two patients died due to progression of their hematological disease. We show the potential risk of hematological disorders in EOC patients treated with chemotherapy and prolonged PARPi therapy. In our series, tr‐HDs incidence was higher compared to recent reports in large series. Our observations suggest careful monitoring in order to conclusively define, on large series and prolonged follow‐up, the actual risk of tr‐HDs in patients under PARPi. Notably, prompt diagnosis of hematological abnormalities and appropriate management allow achievement of remission from severe hematological complications, at least in most patients.  相似文献   
10.
Mechanical intravascular hemolysis is frequently observed following procedures on heart valves and uncommonly observed in native valvular disease. In most cases, its severity is mild. Nevertheless, it can be clinically significant and even life threatening, requiring multiple blood transfusions and renal replacement therapy. This paper reviews the current knowledge on mechanical intravascular hemolysis in valvular disease, before and after correction, focusing on pathophysiology, approach to diagnosis, and impact of other hematological conditions on the resultant anemia. The importance of a multidisciplinary management is underscored. Laboratory data are provided about subclinical hemolysis that is commonly observed following the implantation of surgical and transcatheter valve prostheses and devices. Finally, clinical scenarios are reviewed and current medical and surgical treatments are discussed, including alternative options for inoperable patients.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号