Immunohistochemical expression of TFIIH and XPF in oral tongue squamous cell carcinoma

European Archives of Oto-Rhino-Laryngology - The query for biomarkers that indicate tumor aggressiveness and the host’s response to treatment is still one of the leading aims of cancer...     

Periodontal regenerative potential of autogenous periodontal ligament grafts in Class II furcation defects

BACKGROUND: The aim of the present study was to evaluate the regenerative potential of autogenous periodontal ligament (PDL) grafts in the treatment of Class II furcation defects. METHODS: Twenty mandibular Class II furcation defects from 10 systemically healthy patients with chronic periodontitis were selected. In experimental defects, flaps were coronally positioned following placing autogenous PDL grafts that were obtained from third molars; in controls, coronally advanced flap procedure without graft was applied. Clinical measurements including plaque index, gingival index, probing depth (PD), vertical and horizontal clinical attachment level (CAL), and gingival recession (GR) were obtained at baseline and after 3 and 6 months postoperatively. Vertical and horizontal defect fill was evaluated with open clinical measurements at initial surgery and reentry after 6 months. Gingival biopsies from the experimental and control defects were obtained at reentry and evaluated histopathologically in order to examine the soft tissue response towards PDL grafts. RESULTS: Sites treated with PDL grafts demonstrated significant improvement in vertical and horizontal defect fill, PD, and CAL at 3 and 6 months compared to presurgical values. The difference determined for the PD values of both groups at a statistically significant degree in favor of grafted sites was maintained at all observation periods. No foreign body reaction was observed in PDL grafts. CONCLUSIONS: These short-term results point to the potential of PDL grafts in promoting healing of furcation lesions. This preliminary study suggests that the use of PDL grafts may have beneficial effects in the treatment of furcation defects.     

艾叶去屑方去头屑临床功效评价

目的:观察含5%艾叶去屑方的香波和护发素的去屑临床功效。方法:选择46例头屑过多受试者,通过比较使用前、使用2周和4周后受试者头屑、油脂、马拉色菌菌落变化,以评价5%艾叶去屑方的去屑效果,同时进行受试者自我评估。结果:与使用前相比,使用含5%艾叶去屑方的香波和护发素后,头屑平均分值、平均油脂量、平均马拉色菌菌落数均有不同程度下降,使用4周后比2周后下降更明显,具有显著的统计学意义,且受试者自我评估改善明显。结论:含5%艾叶去屑方的香波和护发素具有显著的去屑作用。     

彩色多普勒超声对睾丸扭转与急性附睾-睾丸炎的鉴别诊断

目的 :探讨彩色多普勒超声对睾丸扭转与急性附睾 -睾丸炎鉴别诊断中的价值。方法 :首先用二维超声显示 14例睾丸扭转与急性附睾 -睾丸炎的睾丸、附睾的位置、大小、形态、回声 ,继之用彩色多普勒(CDFI)观察睾丸、附睾内的血供情况 ,其诊断均经手术或临床证实。结果 :4例睾丸扭转患侧睾丸、附睾内血供减少或消失 ,10例急性附睾 -睾丸炎血供增多。 1例超声检查过程中自行复位后的血供增多 ,易误诊为急性附睾 -睾丸炎。结论 :CDFI作为一种经济、实用、准确、无创性的检查手段 ,是目前鉴别睾丸扭转与急性附睾炎的首选方法。     

Efficacy of Hyperbaric Oxygen Therapy in Diabetic Foot Ulcers Based on Wagner Classification

Diabetic foot ulcer is a common chronic complication of diabetes mellitus. In addition to conventional primary therapy, there are adjuvant therapy methods such as hyperbaric oxygen therapy for the healing of diabetic foot ulcer wounds. The present study aimed to determine the efficacy of hyperbaric oxygen therapy in diabetic foot ulcers based on Wagner classification. It was performed retrospectively from prospectively collected data. One hundred thirty patients with diabetic foot ulcers were assessed in 2 groups: 1 group received hyperbaric oxygen therapy; the other group did not. Patients were examined according to age, sex, ulcer grade based on Wagner classification; ulcer healing status; whether hyperbaric oxygen therapy was received; duration of diabetes in years; HbA1C, sedimentation, C-reactive protein levels; and presence of accompanying diseases, including peripheral arterial disease, chronic obstructive pulmonary disease, hypertension, chronic kidney disease, neuropathy, and retinopathy. The mean follow-up period was 19.5?±?4.45 months (range 12 to 28 months). Seventy-one (54.6%) patients received hyperbaric oxygen therapy, and 59 (45.4%) patients did not. All patients in Wagner grade 2 healed in both groups. In the group that received hyperbaric oxygen therapy for grade 3 and 4 patients, 35 (87.5%) and 11 (84.6%) healed, respectively. In total, 60 (84.5%) patients in the group that received hyperbaric oxygen therapy healed. The subgroup comparison conducted according to Wagner classification revealed no differences between the 2 groups of grades 2 and 5 patients. It also revealed that treatment had higher levels of efficacy in the healing of ulcers in grade 3 and 4 patients.