全文获取类型
收费全文 | 934篇 |
免费 | 59篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 101篇 |
妇产科学 | 15篇 |
基础医学 | 97篇 |
口腔科学 | 17篇 |
临床医学 | 60篇 |
内科学 | 201篇 |
皮肤病学 | 24篇 |
神经病学 | 83篇 |
特种医学 | 40篇 |
外科学 | 144篇 |
综合类 | 58篇 |
预防医学 | 61篇 |
眼科学 | 15篇 |
药学 | 25篇 |
中国医学 | 1篇 |
肿瘤学 | 51篇 |
出版年
2023年 | 4篇 |
2022年 | 4篇 |
2021年 | 13篇 |
2020年 | 5篇 |
2019年 | 5篇 |
2018年 | 23篇 |
2017年 | 3篇 |
2016年 | 15篇 |
2015年 | 22篇 |
2014年 | 35篇 |
2013年 | 30篇 |
2012年 | 55篇 |
2011年 | 70篇 |
2010年 | 44篇 |
2009年 | 33篇 |
2008年 | 42篇 |
2007年 | 47篇 |
2006年 | 53篇 |
2005年 | 52篇 |
2004年 | 35篇 |
2003年 | 35篇 |
2002年 | 36篇 |
2001年 | 30篇 |
2000年 | 27篇 |
1999年 | 27篇 |
1998年 | 20篇 |
1997年 | 16篇 |
1996年 | 16篇 |
1995年 | 15篇 |
1994年 | 14篇 |
1993年 | 7篇 |
1992年 | 12篇 |
1991年 | 18篇 |
1990年 | 9篇 |
1989年 | 14篇 |
1988年 | 10篇 |
1987年 | 7篇 |
1986年 | 13篇 |
1985年 | 6篇 |
1984年 | 8篇 |
1983年 | 9篇 |
1981年 | 3篇 |
1980年 | 6篇 |
1977年 | 10篇 |
1976年 | 4篇 |
1975年 | 3篇 |
1970年 | 4篇 |
1969年 | 5篇 |
1968年 | 2篇 |
1967年 | 2篇 |
排序方式: 共有996条查询结果,搜索用时 15 毫秒
1.
2.
Mohammad U. Malik Stuart D. Russell Aliaksei Pustavoitau Matthews Chacko Arif M. Cosar Carol B. Thompson Panagiotis Trilianos Nabil N. Dagher Andrew M. Cameron Ahmet Gurakar 《Hepatology International》2016,10(6):974-982
Background/purpose
Cardiac morbidities can occur during the peri- and post-liver transplant (LT) period, affecting the long-term survival. The purpose of this study was to identify the potential factors that predict a coronary event post-transplantation.Methods
Medical records of patients who underwent liver transplantation at Johns Hopkins Hospital between 2009 and 2013 were retrospectively reviewed. We looked at pre-liver transplant cardiac risk factors and the diagnostic tests utilized for coronary artery disease screening. Patients with and without post-liver transplant coronary events were compared.Results
There were a total of 146 patients with a mean age at LT of 55.3 years. The prevalence of hypertension, tobacco use and diabetes within the patient population was 61.6 % (n = 90), 39 % (n = 57) and 37.6 % (n = 55), respectively. There were 29 deaths and 30 coronary events over a median follow-up period of 1.75 years. Age at the time of liver transplant was predictive of coronary event (OR 1.11, CI 1.01–1.20). The 1-year survival in patients with a coronary event was 47 versus 94 % in patients without a coronary event. The combined use of a dobutamine stress echocardiogram and coronary artery calcium score predicted a coronary event with a sensitivity of 62.5 % and specificity of 66.7 %.Conclusion
In conclusion, LT recipients with cardiac events had limited survival as compared to the cohort without coronary events. Identification of such patients with noninvasive screening may provide a practical alternative to an invasive cardiac workup. Further improvement in screening strategies may minimize the liver transplant cardiac morbidity.3.
4.
Elsamma Chacko 《Diabetologia》2015,58(6):1372-1373
5.
6.
7.
Neha Reddy Beulah Elsa Anusha Bellapu Vasista Sharma Stephy Chacko Subeesh Viswam 《International journal of clinical pharmacy》2020,42(2):721-727
International Journal of Clinical Pharmacy - Background Signal generation through data mining algorithms is an innovative and emerging field in pharmacovigilance. Early detection of safety signals... 相似文献
8.
Babak Razaghi Shelby L. Steele Sergey V. Prykhozhij Matthew R. Stoyek Jessica A. Hill Matthew D. Cooper Lindsay McDonald William Lin Mads Daugaard Nicolas Crapoulet Simi Chacko Stephen M. Lewis Ian C. Scott Poul H. B. Sorensen Jason N. Berman 《Developmental dynamics》2018,247(2):289-303
Background: In this study, we reveal a previously undescribed role of the HACE1 (HECT domain and Ankyrin repeat Containing E3 ubiquitin‐protein ligase 1) tumor suppressor protein in normal vertebrate heart development using the zebrafish (Danio rerio) model. We examined the link between the cardiac phenotypes associated with hace1 loss of function to the expression of the Rho small family GTPase, rac1, which is a known target of HACE1 and promotes ROS production via its interaction with NADPH oxidase holoenzymes. Results : We demonstrate that loss of hace1 in zebrafish via morpholino knockdown results in cardiac deformities, specifically a looping defect, where the heart is either tubular or “inverted”. Whole‐mount in situ hybridization of cardiac markers shows distinct abnormalities in ventricular morphology and atrioventricular valve formation in the hearts of these morphants, as well as increased expression of rac1. Importantly, this phenotype appears to be directly related to Nox enzyme–dependent ROS production, as both genetic inhibition by nox1 and nox2 morpholinos or pharmacologic rescue using ROS scavenging agents restores normal cardiac structure. Conclusions : Our study demonstrates that HACE1 is critical in the normal development and proper function of the vertebrate heart via a ROS‐dependent mechanism. Developmental Dynamics 247:289–303, 2018. © 2017 Wiley Periodicals, Inc. 相似文献
9.
Anup Gupta Shailesh M. Prabhu Jyoti Sureka Geeta Chacko 《The Egyptian Journal of Radiology and Nuclear Medicine》2013
Purpose
Atypical and malignant meningiomas are considered to have a higher rate of recurrence and show aggressive behavior compared to benign variety. The purpose of our study was to study the role of diffusion weighted imaging and determination of apparent diffusion coefficient (ADC) values and ADC ratios to differentiate typical meningiomas from atypical/malignant variety at 1.5 and 3T MRI.Materials and methods
A total of 94 adult patients (48 patients at 3T and 46 patients at 1.5T) with pathologically proven meningiomas were retrospectively evaluated on conventional and diffusion weighted MRI. The signal intensity of the lesions on DW imaging was evaluated. ADC values and ADC ratios were calculated from lesion and contralateral normal white matter.Results
94 lesions comprising of 66 benign and 28 atypical meningiomas were evaluated. The mean ADC values at 3T MRI were 0.82 ± 0.12 × 10−3 in benign (typical) meningiomas and 0.68 ± 0.10 × 10−3 in atypical meningiomas. At 1.5T, the mean ADC values of benign meningiomas were 0.83 ± 0.11 × 10−3 and 0.70 ± 0.09 × 10−3 in atypical meningiomas. The mean ADC ratios were 1.08 ± 0.17 and 0.85 ± 0.15 for benign and atypical meningiomas respectively. There was a statistically significant difference between the mean ADC ratios and the mean ADC values of typical and atypical meningiomas (P < 0.001) at both 1.5T and 3T MRI.Conclusion
DWI with calculation of apparent diffusion coefficient (ADC) values and ADC ratios has a potential role in differentiating benign from atypical meningiomas at both 1.5 and 3T MRI. The differences in mean ADC values between benign and atypical meningiomas were similar at both 1.5 and 3T MRI. 相似文献10.
Ari George Chacko Santhosh George Thomas K. Srinivasa Babu Roy Thomas Daniel Geeta Chacko Krishna Prabhu Varghese Cherian Grace Korula 《Clinical neurology and neurosurgery》2013