全文获取类型
收费全文 | 2855篇 |
免费 | 161篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 215篇 |
妇产科学 | 52篇 |
基础医学 | 243篇 |
口腔科学 | 34篇 |
临床医学 | 213篇 |
内科学 | 732篇 |
皮肤病学 | 56篇 |
神经病学 | 187篇 |
特种医学 | 79篇 |
外科学 | 630篇 |
综合类 | 14篇 |
预防医学 | 132篇 |
眼科学 | 48篇 |
药学 | 152篇 |
中国医学 | 12篇 |
肿瘤学 | 221篇 |
出版年
2023年 | 19篇 |
2021年 | 67篇 |
2020年 | 45篇 |
2019年 | 63篇 |
2018年 | 73篇 |
2017年 | 49篇 |
2016年 | 82篇 |
2015年 | 60篇 |
2014年 | 76篇 |
2013年 | 114篇 |
2012年 | 150篇 |
2011年 | 155篇 |
2010年 | 78篇 |
2009年 | 82篇 |
2008年 | 125篇 |
2007年 | 137篇 |
2006年 | 104篇 |
2005年 | 117篇 |
2004年 | 119篇 |
2003年 | 109篇 |
2002年 | 107篇 |
2001年 | 71篇 |
2000年 | 74篇 |
1999年 | 58篇 |
1998年 | 24篇 |
1997年 | 16篇 |
1996年 | 16篇 |
1995年 | 24篇 |
1994年 | 16篇 |
1993年 | 16篇 |
1992年 | 73篇 |
1991年 | 55篇 |
1990年 | 56篇 |
1989年 | 66篇 |
1988年 | 66篇 |
1987年 | 68篇 |
1986年 | 62篇 |
1985年 | 52篇 |
1984年 | 39篇 |
1983年 | 22篇 |
1979年 | 29篇 |
1978年 | 14篇 |
1977年 | 15篇 |
1976年 | 14篇 |
1975年 | 13篇 |
1972年 | 15篇 |
1971年 | 18篇 |
1970年 | 13篇 |
1969年 | 13篇 |
1968年 | 13篇 |
排序方式: 共有3025条查询结果,搜索用时 15 毫秒
1.
Murakami Hiroshi Koga Hiroyuki Lane Geoffrey Hirayama Shunki Suzuki Kenji Yamataka Atsuyuki 《Pediatric surgery international》2020,36(1):57-61
Pediatric Surgery International - We studied fissure status and devices used to divide lung parenchyma during thoracoscopic pulmonary lobectomy (TPL). 52 consecutive TPL indicated for congenital... 相似文献
2.
3.
4.
5.
6.
7.
8.
Eikan Mishima Shinji Fukuda Hisato Shima Akiyoshi Hirayama Yasutoshi Akiyama Yoichi Takeuchi Noriko N. Fukuda Takehiro Suzuki Chitose Suzuki Akinori Yuri Koichi Kikuchi Yoshihisa Tomioka Sadayoshi Ito Tomoyoshi Soga Takaaki Abe 《Journal of the American Society of Nephrology : JASN》2015,26(8):1787-1794
The accumulation of uremic toxins is involved in the progression of CKD. Various uremic toxins are derived from gut microbiota, and an imbalance of gut microbiota or dysbiosis is related to renal failure. However, the pathophysiologic mechanisms underlying the relationship between the gut microbiota and renal failure are still obscure. Using an adenine-induced renal failure mouse model, we evaluated the effects of the ClC-2 chloride channel activator lubiprostone (commonly used for the treatment of constipation) on CKD. Oral administration of lubiprostone (500 µg/kg per day) changed the fecal and intestinal properties in mice with renal failure. Additionally, lubiprostone treatment reduced the elevated BUN and protected against tubulointerstitial damage, renal fibrosis, and inflammation. Gut microbiome analysis of 16S rRNA genes in the renal failure mice showed that lubiprostone treatment altered their microbial composition, especially the recovery of the levels of the Lactobacillaceae family and Prevotella genus, which were significantly reduced in the renal failure mice. Furthermore, capillary electrophoresis–mass spectrometry-based metabolome analysis showed that lubiprostone treatment decreased the plasma level of uremic toxins, such as indoxyl sulfate and hippurate, which are derived from gut microbiota, and a more recently discovered uremic toxin, trans-aconitate. These results suggest that lubiprostone ameliorates the progression of CKD and the accumulation of uremic toxins by improving the gut microbiota and intestinal environment. 相似文献
9.
Hiroyuki Koga Kenji Suzuki Kinya Nishimura Manabu Okawada Takashi Doi Geoffrey J. Lane Eiichi Inada Tadaharu Okazaki Atsuyuki Yamataka 《Pediatric surgery international》2014,30(9):937-940
Accurate division and sealing of lung parenchyma particularly in cases of total or near total incomplete fissure are crucial for preventing air leakage following thoracoscopic pulmonary lobectomy (TPL). However, conventional endoscopic stapling devices cannot be used during TPL in small children because of limited space. Consequently, Ligasure (LS) and Enseal (ES) devices are being used instead. We are the first to compare LS and ES for efficacy and efficiency during TPL. Of 26 TPL (6 upper, 3 middle, and 17 lower) performed for congenital adenomatoid malformation (n = 16) and sequestration (n = 10), incomplete fissure was found in 14. TPL (LS = 11; ES = 15) was performed conventionally in the lateral decubitus position with single lung ventilation using four 5 mm trocars. All cases had a chest tube inserted intraoperatively that was left in situ. Patient demographics, location of pathology, incidence of incomplete fissure, mean age/weight at TPL, mean blood loss, and mean operative time were all similar. However, duration of chest tube insertion was significantly shorter in ES because there was less postoperative air leakage (1.3 vs. 3.9 days; p < 0.05). ES would appear to seal lung parenchyma more effectively during TPL based on the shorter duration of chest tube insertion. 相似文献
10.
Ryo Sueyoshi Manabu Okawada Junya Fujimura Masahiro Saito Hiroyuki Koga Geoffrey J. Lane Atsuyuki Yamataka 《Pediatric surgery international》2014,30(9):965-969
Ewing sarcoma (ES) of the bladder is extremely rare. Here we report the successful treatment of the youngest case of ES arising from bladder encountered to date and a literature review. A 10-year-old boy who presented with polyuria and lower abdominal swelling was found to have a 13 cm mass arising from the bladder localized to the center of the lower abdomen. Biopsy confirmed ES. Following chemotherapy, the mass shrank to 5 cm and was found to be localized to the right side of the bladder with invasion of the right vas deferens. One-third of the right side of the bladder and part of the right vas deferens were resected. No viable cancer cells were detected in the resected specimen, and the surgical margins were reported to be negative. The patient is currently well with no recurrence or metastases after 11 months. There are 12 cases of Ewings sarcoma arising from the bladder reported in the English literature; two cases in children. Our case will be the third pediatric case and the youngest. 相似文献