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??Abstract?? Objective To summarize the clinical features of hepatic glycogen storage disease to improve the diagnosis and treatment and decrease the possibility of misdiagnosis. Methods Twelve cases of hepatic glycogen storage disease in Shengjing Hospital from May, 2007 to November, 2013 were analyzed retrospectively and followed up. Results Two cases were misdiagnosed in the 5 final diagnosed cases at first treatment. Liver dysfunction and growth retardation are the main symptoms, 2 cases with low blood glucose and 3 cases with jaundice??4 cases were screened positive result for epinephrine stimulating test. Two time of follow-up confirmed these cases still suffered from hepatomegaly and splenomegaly, liver dysfunction, growth retardation, etc. In suspected diagnosed group,only 1 case was screened positive result for epinephrine stimulating test. Conclusion The clinical manifestations of hepatic glycogen storage disease are multiple. Therefore, physicians should have sufficient recognition for this disease and give a right and prompt diagnosis based on family history, physical examinations and laboratory findings.     

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??Histologic types of benign breast disease and the risk of breast cancer LIU Lu, ZHENG Xin-yu. Department of Breast Surgery, the First Hospital of China Medical University, Shenyang 110001, China
Corresponding author:ZHENG Xin-yu, E-mail: xyzheng126@126.com
Abstract Some histologic types of benign breast disease (BBD) increase the risk of breast cancer. Histologically BBD are classified into nonproliferative and proliferative disease with and without atypia. The risk is higher in women with proliferative disease with atypia followed by those with proliferative disease without atypia. Generally women with nonproliferative disease and without a family history of breast cancer have no elevation in breast cancer risk compared with women of similar age from the general population. However, it is less clear whether histologic entities such as complex sclerosing adenosis, radial scar, and papilloma are associated with increased risk in the absence of atypical hyperplasia.     

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??Abstract??The patent foramen ovale (PFO) persists during fetal life and approximately 1 of every 4 adults.In recent years??PFO has been implicated in the etiology of cryptogenic stroke secondary to paradoxical embolism??migraine headache??platypneaorthodeoxia syndrome and neurologic decompression illness.This article focuses on the relationship between PFO and PDE??the current research status and treatment of PFO-related syndromes??so as to further understand PFO and PDE??thus proposing theoretical evidence for the treatment of PFO-related syndromes.     

细胞因子诱导的imDCs鉴定及免疫学功能研究

目的:分析未成熟树突状细胞(immature dendritic cells,imDCs)的免疫学功能,诱导同种异体复合组织移植局部免疫耐受性。方法:采用细胞因子诱导培养黏附法,取大鼠骨髓前体细胞,粒细胞-巨噬细胞集落刺激因子联合白细胞介素-4细胞因子诱导下培养7 d,收集贴壁细胞光学显微镜观察imDCs的形态学特征,用质量分数2%锥虫蓝染色检测活性细胞率;应用流式细胞仪分析imDCs表面标志分子;MTT比色法测定imDCs与同种异体T淋巴细胞混合培养后T淋巴细胞的增殖能力。结果:制备诱导培养的imDCs具有形态不规则、表面粗糙层叠状皱褶、胞质突起短而多、树枝样分叉明显等典型形态特征;活性细胞率高达93%;表面较特异标志分子OX62为(61.08±4.86)%,OX62阳性细胞表达CD80、CD86、组织相容性复合体-Ⅱ表达率分别为(3.56±0.73)%、(5.38±1.09)%、(6.45±0.74)%,均为较低表达;imDCs对同种异体T淋巴细胞基本无刺激增殖能力。结论:用细胞因子诱导培养黏附法取骨髓前体细胞,可较快分选出活性和纯度较高、数量足够的imDCs,为同种异体复合组织移植诱导免疫耐受防止排斥反应的研究奠定良好的基础。     

糖尿病并高血压的药物康复治疗

糖尿病患常伴有高血压。高血压的发生率在糖尿病人群是非糖尿尿病人群的两倍，高血压和糖尿病均被认为是发生大血管和微血管病变的危险因素．高血压控制不良．常常导致肾功能减退，继而肾功能衰竭。当平均动脉压(MAP)保持在92mmHg以下时，肾衰的进程可能会停止，所以抗高血压治疗可以减慢糖尿病肾病的发展。     

拔出部分代偿性气管套管置胃管法在临床中的应用

人体的大脑缺氧超过5min,脑细胞将产生不可逆的损害.当患者自主呼吸暂停或过弱,不能维持必要的每分钟通气量时,则需要机械装置来增加通气量,提供氧疗,改善换气功能,减少呼吸能量消耗.它是支持呼吸、循环功能不全的重要手段.最常用、最直接、最有效的方法便是及时行气管切开并行呼吸机辅助呼吸.     

阿立哌唑致脱发一例

阿立哌唑引起脱发的报道不多，现将具有完整病程记录的1例报告如下     

5-氟尿嘧啶对创伤性胰外瘘的治疗作用

本组３例均为胰体尾部挫裂伤术后并发了胰外瘘，男性２例，女性１例，年龄１５～４８岁。病程为腹部探查术后４～３５ｄ。２例患者腹腔引流液为清亮的胰液，胰液日流量２００～３５０ｍｌ左右。１例属于过早的排除腹腔引流管后，引流口溢出清亮的液体，不断地浸湿敷料和外敷的卫生纸，日用卫生纸４～５包不等。２例患者伴有低热，１例有左上腹部胀痛和轻度贫血貌，腹壁瘘口红肿，有淡黄色渗出物粘附。引流液淀粉酶测定 １２１４～１５３６Ｕ。 １倒尿淀粉酶 １５３８．４Ｕ。血常规１例Ｈｂ９８ｇ／Ｌ，２例ＷＢＣ轻度增加，１例血常规正常…