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Tada Kazuhiro Iwashita Yukio Shiraiwa Ken Uchida Hiroki Oshima Yusuke Sato Yuhki Nakanuma Hiroaki Hirashita Teijiro Masuda Takashi Endo Yuichi Takeuchi Yu Ohta Masayuki Itoh Hiroki Inomata Masafumi 《Cancer chemotherapy and pharmacology》2020,85(2):345-352
Cancer Chemotherapy and Pharmacology - Chemotherapy after hepatectomy for colorectal liver metastasis has not been established, due to the toxic side effects, which are likely related to impaired... 相似文献
3.
Nakahara Keiichi Nakane Shunya Kitajima Mika Masuda-Narita Tomoko Matsuo Hidenori Ando Yukio 《Journal of neurology》2020,267(3):752-759
Journal of Neurology - To determine the usefulness of MRI measurements in patients with pure akinesia with gait freezing (PAGF), Richardson’s syndrome, and Parkinson’s disease for... 相似文献
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Yusuke Masuo Yuri Ohba Kohei Yamada Aya Hasan Al-Shammari Natsumi Seba Noritaka Nakamichi Takuo Ogihara Munetaka Kunishima Yukio Kato 《Pharmaceutical research》2018,35(11):224
Purpose
Solute carrier SLC22A4 encodes the carnitine/organic cation transporter OCTN1 and is associated with inflammatory bowel disease, although little is known about how this gene is linked to pathogenesis. The aim of the present study was to identify endogenous substrates that are associated with gastrointestinal inflammation.Methods
HEK293/OCTN1 and mock cells were incubated with colon extracts isolated from dextran sodium sulfate-induced colitis mice; the subsequent cell lysates were mixed with the amino group selective reagent 3-aminopyridyl-N-hydroxysuccinimidyl carbamate (APDS), to selectively label OCTN1 substrates. Precursor ion scanning against the fragment ion of APDS was then used to identify candidate OCTN1 substrates.Results
Over 10,000 peaks were detected by precursor ion scanning; m/z 342 had a higher signal in HEK293/OCTN1 compared to mock cells. This peak was detected as a divalent ion that contained four APDS-derived fragments and was identified as spermine. Spermine concentration in peripheral blood mononuclear cells from octn1 gene knockout mice (octn1?/?) was significantly lower than in wild-type mice. Lipopolysaccharide-induced gene expression of inflammatory cytokines in peritoneal macrophages from octn1?/? mice was lower than in wild-type mice.Conclusions
The combination metabolomics approach can provide a novel tool to identify endogenous substrates of OCTN1.6.
Goto Yukinobu Hiramatsu Yuji Ageyama Naohide Sato Shoko Mathis Bryan J. Kitazawa Shinsuke Matsubara Muneaki Sakamoto Hiroaki Sato Yukio 《Journal of artificial organs》2019,22(1):44-52
Journal of Artificial Organs - Cardiopulmonary bypass (CPB) recovery is complicated by lung inflammation from bone marrow (BM)-derived polymorphonuclear leukocytes (PMNs) and monocytes (MO).... 相似文献
7.
Masayoshi Tasaki Mitsuharu Ueda Yoshinobu Hoshii Mayumi Mizukami Sayaka Matsumoto Makoto Nakamura Taro Yamashita Akihiko Ueda Yohei Misumi Teruaki Masuda Yasuteru Inoue Tessei Torikai Toshiya Nomura Yukimoto Tsuda Kyosuke Kanenawa Aito Isoguchi Masamitsu Okada Hirotaka Matsui Konen Obayashi Yukio Ando 《The Journal of pathology》2019,247(4):444-455
Most intractable tissue-degenerative disorders share a common pathogenic condition, so-called proteinopathy. Amyloid-related disorders are the most common proteinopathies and are characterized by amyloid fibril deposits in the brain or other organs. Aging is generally associated with the development of these amyloid-related disorders, but we still do not fully understand how functional proteins become pathogenic amyloid deposits during the human aging process. We identified a novel amyloidogenic protein, named epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1), in massive venous amyloid deposits in specimens that we obtained from an autopsied patient who died of gastrointestinal bleeding. Our postmortem analyses of additional patients indicate that EFEMP1 amyloid deposits frequently developed in systemic venous walls of elderly people. EFEMP1 was highly expressed in veins, and aging enhanced venous EFEMP1 expression. In addition, biochemical analyses indicated that these venous amyloid deposits consisted of C-terminal regions of EFEMP1. In vitro studies showed that C-terminal regions formed amyloid fibrils, which inhibited venous tube formation and cell viability. EFEMP1 thus caused a novel age-related venous amyloid-related disorder frequently found in the elderly population. Understanding EFEMP1 amyloid formation provides new insights into amyloid-related disorders occurring during the aging process. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. 相似文献
8.
Yamada Y Hossain M Kimura Y Nakamura Y Masuda Y Shimizu Y Matsumoto K 《The Journal of clinical pediatric dentistry》2007,31(3):199-201
In the present study, removal of artifcial plaque in pits and fissures with the Carisolv system was compared with that of conventional bristle brush methoda in vitro. The results indicate that in the dental clinic, complete plaque removal with the Carisolv is possible, and in addition to acid etching, treated cavity was almost free of debris which might increase sealant retention. 相似文献
9.
Takami Y Nakagaki H Morita I Tsuboi S Takami S Suzuki N Niwa H Ogura Y 《Journal of periodontology》2003,74(12):1778-1784
BACKGROUND: We examined the blood test values of people who received general medical checkups and their Community Periodontal Index (CPI) score. METHODS: A total of 7,452 persons (5,742 males and 1,710 females), who had general medical and dental checkups, were the subjects of the study. Many were people who worked for companies in and around Nagoya and their family members, ranging in age from 16 to 80 years. The blood test in our study consisted of 37 items used in general blood tests. Partial-mouth recordings were used to measure CPI scores. The highest CPI score for each subject was used for analysis. Odds ratios and confidence interval values were obtained using the Mantel-Haenszel method to analyze the results. RESULTS: CPI scores of 3 and 4 were related to the test values of high-density-lipoprotein cholesterol, serum iron, white blood cell count, fasting blood sugar, glycosylated hemoglobin A1, glycosylated hemoglobin A1c, and C-reactive protein. CONCLUSION: Blood test values tended to show correlations with CPI scores, more clearly seen in males than in females. 相似文献
10.
Machado AG Komiyama EY Santos SS Jorge AO Brighenti FL Koga-Ito CY 《Journal of applied oral science : revista FOB》2011,19(4):384-387
Adherence is considered an extremely important virulence factor in yeast.