全文获取类型
收费全文 | 6965篇 |
免费 | 377篇 |
国内免费 | 57篇 |
专业分类
耳鼻咽喉 | 75篇 |
儿科学 | 162篇 |
妇产科学 | 147篇 |
基础医学 | 708篇 |
口腔科学 | 151篇 |
临床医学 | 427篇 |
内科学 | 1889篇 |
皮肤病学 | 107篇 |
神经病学 | 515篇 |
特种医学 | 282篇 |
外科学 | 1302篇 |
综合类 | 41篇 |
一般理论 | 1篇 |
预防医学 | 228篇 |
眼科学 | 182篇 |
药学 | 420篇 |
中国医学 | 11篇 |
肿瘤学 | 751篇 |
出版年
2023年 | 34篇 |
2022年 | 30篇 |
2021年 | 147篇 |
2020年 | 90篇 |
2019年 | 115篇 |
2018年 | 152篇 |
2017年 | 107篇 |
2016年 | 140篇 |
2015年 | 157篇 |
2014年 | 176篇 |
2013年 | 251篇 |
2012年 | 386篇 |
2011年 | 383篇 |
2010年 | 257篇 |
2009年 | 224篇 |
2008年 | 340篇 |
2007年 | 397篇 |
2006年 | 386篇 |
2005年 | 333篇 |
2004年 | 393篇 |
2003年 | 358篇 |
2002年 | 370篇 |
2001年 | 201篇 |
2000年 | 180篇 |
1999年 | 177篇 |
1998年 | 83篇 |
1997年 | 62篇 |
1996年 | 65篇 |
1995年 | 53篇 |
1994年 | 62篇 |
1993年 | 50篇 |
1992年 | 108篇 |
1991年 | 107篇 |
1990年 | 100篇 |
1989年 | 95篇 |
1988年 | 104篇 |
1987年 | 95篇 |
1986年 | 98篇 |
1985年 | 73篇 |
1984年 | 66篇 |
1983年 | 44篇 |
1982年 | 32篇 |
1981年 | 24篇 |
1979年 | 33篇 |
1977年 | 24篇 |
1975年 | 27篇 |
1974年 | 26篇 |
1973年 | 20篇 |
1971年 | 23篇 |
1970年 | 23篇 |
排序方式: 共有7399条查询结果,搜索用时 15 毫秒
1.
Yoshihiro Noda 《Psychiatry and clinical neurosciences》2020,74(1):12-34
Transcranial magnetic stimulation (TMS) can depolarize the neurons directly under the coil when applied to the cerebral cortex, and modulate the neural circuit associated with the stimulation site, which makes it possible to measure the neurophysiological index to evaluate excitability and inhibitory functions. Concurrent TMS and electroencephalography (TMS‐EEG) has been developed to assess the neurophysiological characteristics of cortical regions other than the motor cortical region noninvasively. The aim of this review is to comprehensively discuss TMS‐EEG research in the healthy brain focused on excitability, inhibition, and plasticity following neuromodulatory TMS paradigms from a neurophysiological perspective. A search was conducted in PubMed to identify articles that examined humans and that were written in English and published by September 2018. The search terms were as follows: (TMS OR ‘transcranial magnetic stimulation’) AND (EEG OR electroencephalog*) NOT (rTMS OR ‘repetitive transcranial magnetic stimulation’ OR TBS OR ‘theta burst stimulation’) AND (healthy). The study presents an overview of TMS‐EEG methodology and neurophysiological indices and reviews previous findings from TMS‐EEG in healthy individuals. Furthermore, this review discusses the potential application of TMS‐EEG neurophysiology in the clinical setting to study healthy and diseased brain conditions in the future. Combined TMS‐EEG is a powerful tool to probe and map neural circuits in the human brain noninvasively and represents a promising approach for determining the underlying pathophysiology of neuropsychiatric disorders. 相似文献
2.
Mamiko Onuki Koji Matsumoto Takashi Iwata Kasumi Yamamoto Yoichi Aoki Shoji Maenohara Naotake Tsuda Shoji Kamiura Kazuhiro Takehara Koji Horie Nobutaka Tasaka Hideaki Yahata Yuji Takei Yoichi Aoki Hisamori Kato Takeshi Motohara Keiichiro Nakamura Mitsuya Ishikawa Tatsuya Kato Hiroyuki Yoshida Noriomi Matsumura Hidekatsu Nakai Shogo Shigeta Fumiaki Takahashi Kiichiro Noda Nobuo Yaegashi Hiroyuki Yoshikawa 《Cancer science》2020,111(7):2546-2557
To obtain baseline data for cervical cancer prevention in Japan, we analyzed human papillomavirus (HPV) data from 5045 Japanese women aged less than 40 years and diagnosed with cervical abnormalities at 21 hospitals during 2012‐2017. These included cervical intraepithelial neoplasia grade 1 (CIN1, n = 573), CIN2‐3 (n = 3219), adenocarcinoma in situ (AIS, n = 123), and invasive cervical cancer (ICC, n = 1130). The Roche Linear Array was used for HPV genotyping. The HPV type‐specific relative contributions (RCs) were estimated by adding multiple infections to single types in accordance with proportional weighting attributions. Based on the comparison of type‐specific RCs between CIN1 and CIN2‐3/AIS/ICC (CIN2+), RC ratios were calculated to estimate type‐specific risks for progression to CIN2+. Human papillomavirus DNA was detected in 85.5% of CIN1, 95.7% of CIN2‐3/AIS, and 91.2% of ICC. Multiple infections decreased with disease severity: 42.9% in CIN1, 40.4% in CIN2‐3/AIS, and 23.7% in ICC (P < .0001). The relative risk for progression to CIN2+ was highest for HPV16 (RC ratio 3.78, 95% confidence interval [CI] 3.01‐4.98), followed by HPV31 (2.51, 1.54‐5.24), HPV18 (2.43, 1.59‐4.32), HPV35 (1.56, 0.43‐8.36), HPV33 (1.01, 0.49‐3.31), HPV52 (0.99, 0.76‐1.33), and HPV58 (0.97, 0.75‐1.32). The relative risk of disease progression was 1.87 (95% CI, 1.71‐2.05) for HPV16/18/31/33/35/45/52/58, but only 0.17 (95% CI, 0.14‐0.22) for HPV39/51/56/59/66/68. Human papillomavirus 16/18/31/33/45/52/58/6/11 included in a 9‐valent vaccine contributed to 89.7% (95% CI, 88.7‐90.7) of CIN2‐3/AIS and 93.8% (95% CI, 92.4‐95.3) of ICC. In conclusion, our data support the Japanese guidelines that recommend discriminating HPV16/18/31/33/35/45/52/58 genotypes for CIN management. The 9‐valent vaccine is estimated to provide over 90% protection against ICC in young Japanese women. 相似文献
3.
4.
5.
Naoko Shoji Keiji Tanese Ayano Sasaki Taishi Horiuchi Yuji Utsuno Koichi Fukuda Yukiko Hoshino Shinichi Noda Hirofumi Minami Wataru Asakura Amenamevir Review Team 《The Journal of dermatology》2020,47(7):683-688
In July 2017, Japan’s Ministry of Health, Labor and Welfare issued a marketing authorization valid throughout Japan for N-(2,6-dimethylphenyl)-N-(2-{[4-(1,2,4-oxadiazol-3-yl)phenyl]amino}-2-oxoethyl)-1,1-dioxothiane-4-carboxamide (amenamevir) for the first time worldwide. The decision was based on the favorable opinion of the Pharmaceuticals and Medical Device Agency (PMDA) recommending a marketing authorization of amenamevir for treatment of herpes zoster (HZ). Amenamevir has a different action mechanism from previously approved synthetic nucleoside compounds for the treatment of HZ including acyclovir, valacyclovir and famciclovir. The usual adult dose is 400 mg amenamevir p.o. once daily for 7 days. The benefit is its ability to cure HZ as well as preventing postherpetic neuralgia. The most common side-effects are increase of urine N-acetyl-β-D-glucosaminidase and α1-microglobulin levels. However, based on the detailed evaluation of the submitted clinical studies, there seems to be no serious safety concerns about amenamevir regarding the kidney of both renally normal and impaired patients. The objective of this article is to summarize the scientific review of the application. The detailed scientific assessment report and product information, including the summary of product characteristics, are available on the PMDA website ( www.pmda.go.jp/PmdaSearch/iyakuSearch/ ). 相似文献
6.
7.
The relationship between prostate‐specific antigen and TNM classification or Gleason score in prostate cancer patients with low prostate‐specific antigen levels 下载免费PDF全文
8.
A Left Anterior Extrapleural Approach to Adjust Right Ventricle–Pulmonary Artery Shunt Flow Using Hemostatic Clips After the Norwood Operation 下载免费PDF全文
9.
10.