全文获取类型
收费全文 | 1024篇 |
免费 | 64篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 32篇 |
儿科学 | 23篇 |
妇产科学 | 9篇 |
基础医学 | 99篇 |
口腔科学 | 11篇 |
临床医学 | 107篇 |
内科学 | 377篇 |
皮肤病学 | 13篇 |
神经病学 | 66篇 |
特种医学 | 35篇 |
外科学 | 150篇 |
综合类 | 5篇 |
预防医学 | 17篇 |
眼科学 | 15篇 |
药学 | 58篇 |
中国医学 | 3篇 |
肿瘤学 | 72篇 |
出版年
2021年 | 21篇 |
2020年 | 9篇 |
2019年 | 13篇 |
2018年 | 22篇 |
2017年 | 20篇 |
2016年 | 22篇 |
2015年 | 17篇 |
2014年 | 22篇 |
2013年 | 27篇 |
2012年 | 42篇 |
2011年 | 59篇 |
2010年 | 26篇 |
2009年 | 33篇 |
2008年 | 47篇 |
2007年 | 53篇 |
2006年 | 42篇 |
2005年 | 54篇 |
2004年 | 41篇 |
2003年 | 39篇 |
2002年 | 52篇 |
2001年 | 36篇 |
2000年 | 54篇 |
1999年 | 58篇 |
1998年 | 9篇 |
1997年 | 6篇 |
1996年 | 7篇 |
1995年 | 5篇 |
1994年 | 9篇 |
1993年 | 5篇 |
1992年 | 11篇 |
1991年 | 21篇 |
1990年 | 9篇 |
1989年 | 16篇 |
1988年 | 11篇 |
1987年 | 14篇 |
1986年 | 8篇 |
1985年 | 18篇 |
1984年 | 9篇 |
1983年 | 11篇 |
1979年 | 10篇 |
1978年 | 7篇 |
1977年 | 6篇 |
1976年 | 6篇 |
1974年 | 9篇 |
1973年 | 9篇 |
1972年 | 13篇 |
1971年 | 5篇 |
1970年 | 9篇 |
1969年 | 9篇 |
1968年 | 5篇 |
排序方式: 共有1092条查询结果,搜索用时 15 毫秒
1.
Takashi Nagashima Takehiko Ouchi Kazuhiko Kanaya 《Odontology / the Society of the Nippon Dental University》1999,86(4):854-862
The purpose of this study was to evaluate the quantitative changes in tooth mobility before and after periodontal surgery
using a tooth mobility tester. The tester was so designed as to be able to measure the cycle of sympathetic vibrations produced
when a tooth was tapped with a impact hammer. Initially the degrees of tooth mobility, which were clinically classified from
0 to 3, were observed and the mode of mobility was assessed by the tester. Then, we examined the changes of tooth mobility
after flap surgery. The following is a summary of findings.
1) | The coefficient of change in measurements had a tendency to decrease at the buccal site and the cervical site. |
2) | At 1 week after flap surgery, the degree of tooth mobility was increased significantly. |
3) | At the 6th week after surgery, tooth mobility had returned to the preoperative level. |
4) | At 6 months after surgery, the mobility was decreased significantly compared to immediatery after surgery. |
5) | The extent of bone absorption, probing pocket depth and clinical attachment level did not influence the postoperative changes of tooth mobility. |
相似文献
2.
3.
Yamano H Yamazaki T Sato K Shiga S Hagiwara T Ouchi K Kishimoto T 《Antimicrobial agents and chemotherapy》2005,49(6):2519-2521
The inhibitory effects of hinokitiol (beta-thujaplicin) on Chlamydia trachomatis D/UW-3/Cx were shown by MIC, minimum lethal concentration (MLC), and preinoculation minimal microbicidal concentration assays using HeLa 229 cells. The MIC and the MLC were both 32 microg/ml. Further evaluation of hinokitiol as a topical agent against C. trachomatis is warranted. 相似文献
4.
Fujita M Ye Q Ouchi H Harada E Inoshima I Kuwano K Nakanishi Y 《Antimicrobial agents and chemotherapy》2006,50(2):739-743
The administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity. 相似文献
5.
Ohmae E Ouchi Y Oda M Suzuki T Nobesawa S Kanno T Yoshikawa E Futatsubashi M Ueda Y Okada H Yamashita Y 《NeuroImage》2006,29(3):697-705
We compared pharmacologically-perturbed hemodynamic parameters (cerebral blood volume; CBV, and flow; CBF) by acetazolamide administration in six healthy human subjects studied with positron emission tomography (PET) and near-infrared (NIR) time-resolved spectroscopy (TRS) simultaneously to investigate whether NIR-TRS could measure in vivo hemodynamics in the brain tissue quantitatively. Simultaneously with the PET measurements, TRS measurements were performed at the forehead with four different optode spacing from 2 cm to 5 cm. Total hemoglobin and oxygen saturation (SO2) measured by TRS significantly increased after administration of acetazolamide at any optode spacing in all subjects. In PET study, CBV and CBF were estimated in the following three volumes of interest (VOIs) determined on magnetic resonance images, VOI1: scalp and skull, VOI2: gray matter region, VOI3: gray and white matter regions. Acetazolamide treatment elevated CBF and CBV significantly in VOI2 and VOI3 but VOI1. TRS-derived CBV was more strongly correlated with PET-derived counterpart in VOI2 and VOI3 when the optode spacing was above 4 cm, although optical signal from cerebral tissue could be caught with any optode spacing. As to increase of the CBV, 4 cm of optode spacing correlated best with VOI2. To support the result of TRS-PET experiment, we also estimated the contribution ratios of intracerebral tissue to observed absorption change based on diffusion theory. The contribution ratios at 4 cm were estimated as follows: 761 nm: 50%, 791 nm: 72%, 836 nm: 70%. These results demonstrated that NIR-TRS with 4 cm of optode spacing could measure cerebral hemodynamic responses optimally and quantitatively. 相似文献
6.
Kiyoaki Ouchi Jun Tanabe Tsuyoshi Tominaga Koji Ito Susumu Saijo Seiki Matsuno 《Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie》1993,193(1):81-88
The release of oxygen-derived free radicals has been implicated in endotoxin-mediated hepatic injury. The effect of hepatic
lipid peroxidation on tissue energy reserves in the livers of normal and cirrhotic rats was studied following administraton
ofE. coli endotoxin. Before endotoxin injection, the basal hepatic energy charge was lower and levels of hepatic malondialdehyde (MDA)
and total glutathione (GSH) higher in cirrhotic rats than in normal rats. Virtually identical levels of blood endotoxin were
obtained in the two groups 24h after injection of LD50 doses of endotoxin (20 mg/kg and 1 mg/kg in normal and cirrhotic rats,
respectively). Hepatic energy charge, tissue blood flow, GSH and glutathione peroxidase (GPX) were consistently or transiently
decreased up to 24h after the injection of endotoxin in both normal and cirrhotic rats. MDA, significantly increased in normal
rats 1 h after injection of endotoxin, returned to normal levels 3–12 h after endotoxin administration, but was again elevated
at 24 h. Cirrhotic rats did not show any significant change in MDA following endotoxin injection. In normal rats, endotoxin
appears to trigger the liberation of free radicals accelerating depletion of hepatic energy reserves, over and above the effect
of decreased hepatic blood flow. In contrast, increased lipid peroxidation was not detected in cirrhotic rats despite GSH
and GPX consumption during endotoxemia (indicating oxygen radical generation). Cirrhotic livers were apparently protected
against oxygen radical injury by higher levels of endogenous GSH and GPX. Reduced hepatic blood flow may be mainly responsible
for the alteration in energy metabolism of the cirrhotic liver. 相似文献
7.
Purpose
To evaluate the postoperative outcomes of cataract eyes complicated with coexisting ocular pathologies that underwent implantation of a refractive multifocal intraocular lens (MIOL) with a surface-embedded near section.Methods
LENTIS MPlus (Oculentis GmbH) refractive MIOLs were implanted in 15 eyes with ocular pathologies other than cataract (ie, six high-myopia eyes with an axial length longer than 28 mm, two fundus albipunctatus eyes, two branch retinal-vein occlusion eyes, four glaucoma eyes (one with high myopia), and two keratoconus eyes). Uncorrected or corrected distance and near visual acuity (VA) (UDVA, UNVA, CDVA, and CNVA), contrast sensitivity, and defocus curve were measured at 1 day and 6 months postoperatively, and each patient completed a 6-month postoperative questionnaire regarding vision quality and eyeglass use.Results
Thirteen eyes (87%) registered 0 or better in CDVA and 12 eyes (73%) registered better than 0 in CNVA. Contrast sensitivity in the eyes of all patients was comparable to that of normal healthy subjects. No patient required eyeglasses for distance vision, but three patients (20%) required them for near vision. No patient reported poor or very poor vision quality.Conclusion
With careful case selection, sectorial refractive MIOL implantation is effective for treating cataract eyes complicated with ocular pathologies. 相似文献8.
Varicella‐zoster virus‐specific,cell‐mediated immunity with interferon‐gamma release assay after vaccination of college students with no or intermediate IgG antibody response 下载免费PDF全文
9.
Eui Young So Mutsuko Ouchi Sara Cuesta-Sancho Susan Losee Olson Dirk Reif Kazuhiro Shimomura Toru Ouchi 《Cancer biology & therapy》2015,16(3):460-465
Resistant maltodextrin Fibersol-2 is a soluble and fermentable dietary fiber that is Generally Recognized As Safe (GRAS) in the United States. We tested whether Fibersol-2 contains anti-tumor activity. Human colorectal cancer cell line, HCT116, and its isogenic cells were treated with FIbersol-2. Tumor growth and tumorigenesis were studied in vitro and in vivo. Apoptotic pathway and generation of reactive oxygen species (ROS) were investigated. We discovered that Fibersol-2 significantly inhibits tumor growth of HCT116 cells by inducing apoptosis. Fibersol-2 strongly induces mitochondrial ROS and Bax-dependent cleavage of caspase 3 and 9, which is shown by isogenic HCT116 variants. Fibersol-2 induces phosphorylation of Akt, mTOR in parental HCT116 cells, but not in HCT116 deficient for Bax or p53. It prevents growth of tumor xenograft without any apparent signs of toxicity in vivo. These results identify Fibersol-2 as a mechanism-based dietary supplement agent that could prevent colorectal cancer development. 相似文献
10.
Analyses of Genetic and Clinical Parameters for Screening Patients With Inherited Thrombocytopenia with Small or Normal‐Sized Platelets 下载免费PDF全文
Meri Ouchi‐Uchiyama MD PhD Yoji Sasahara MD PhD Atsuo Kikuchi MD PhD Kumiko Goi MD PhD Takaya Nakane MD PhD Mitsuru Ikeno MD PhD Yasushi Noguchi MD PhD Naokuni Uike MD PhD Yuji Miyajima MD PhD Kousaku Matsubara MD PhD Katsuyoshi Koh MD PhD Kanji Sugita MD PhD Masue Imaizumi MD PhD Shigeo Kure MD PhD 《Pediatric blood & cancer》2015,62(12):2082-2088