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1.
Nagaendran Kandiah Yee Fai Chan Christopher Chen Darwin Dasig Jacqueline Dominguez Seol-Heui Han Jianping Jia SangYun Kim Panita Limpawattana Li-Ling Ng Dinh Toan Nguyen Paulus Anam Ong Encarnita Raya-Ampil Nor'izzati Saedon Vorapun Senanarong Siti Setiati Harjot Singh Chuthamanee Suthisisang Tong Mai Trang Yuda Turana Narayanaswamy Venketasubramanian Fee Mann Yong Yong Chul Youn Ralf Ihl 《CNS Neuroscience & Therapeutics》2021,27(2):149-162
BackgroundMild cognitive impairment (MCI) is a neurocognitive state between normal cognitive aging and dementia, with evidence of neuropsychological changes but insufficient functional decline to warrant a diagnosis of dementia. Individuals with MCI are at increased risk for progression to dementia; and an appreciable proportion display neuropsychiatric symptoms (NPS), also a known risk factor for dementia. Cerebrovascular disease (CVD) is thought to be an underdiagnosed contributor to MCI/dementia. The Ginkgo biloba extract, EGb 761®, is increasingly being used for the symptomatic treatment of cognitive disorders with/without CVD, due to its known neuroprotective effects and cerebrovascular benefits.AimsTo present consensus opinion from the ASian Clinical Expert group on Neurocognitive Disorders (ASCEND) regarding the role of EGb 761® in MCI.Materials & MethodsThe ASCEND Group reconvened in September 2019 to present and critically assess the current evidence on the general management of MCI, including the efficacy and safety of EGb 761® as a treatment option.ResultsEGb 761® has demonstrated symptomatic improvement in at least four randomized trials, in terms of cognitive performance, memory, recall and recognition, attention and concentration, anxiety, and NPS. There is also evidence that EGb 761® may help delay progression from MCI to dementia in some individuals.DiscussionEGb 761® is currently recommended in multiple guidelines for the symptomatic treatment of MCI. Due to its beneficial effects on cerebrovascular blood flow, it is reasonable to expect that EGb 761® may benefit MCI patients with underlying CVD.ConclusionAs an expert group, we suggest it is clinically appropriate to incorporate EGb 761® as part of the multidomain intervention for MCI. 相似文献
2.
Siti Zamratol-Mai S. Mukari Xuan Yu Wan Syafira Ishak Rafidah Mazlan 《International journal of audiology》2015,54(12):951-957
Objective: The aims of the present study were to determine the effects of language background on the performance of the pitch pattern sequence test (PPST) and duration pattern sequence test (DPST). As temporal order sequencing may be affected by age and working memory, these factors were also studied. Design: Performance of tonal and non-tonal language speakers on PPST and DPST were compared. Study sample: Twenty-eight native Mandarin (tonal language) speakers and twenty-nine native Malay (non-tonal language) speakers between seven to nine years old participated in this study. Results: The results revealed that relative to native Malay speakers, native Mandarin speakers demonstrated better scores on the PPST in both humming and verbal labeling responses. However, a similar language effect was not apparent in the DPST. An age effect was only significant in the PPST (verbal labeling). Finally, no significant effect of working memory was found on the PPST and the DPST. Conclusion: These findings suggest that the PPST is affected by tonal language background, and highlight the importance of developing different normative values for tonal and non-tonal language speakers. 相似文献
3.
4.
Siti Nurhuda Sharudin Mohamad Fathi Ismail Suresh Kumar Vasudevan 《Neuro-ophthalmology (Aeolus Press)》2019,43(2):102-106
The rise in popularity of hyaluronic acid (HA) dermal filler injection has caused an exceptional increase in the number of cases of reported irreversible blindness. Here, we reported a case of ischemic optic neuropathy and ophthalmoplegia following subcutaneous HA filler injection with complete visual recovery. A 31-year-old Chinese woman presented with sudden onset of right monocular visual impairment associated with diplopia. Patient had received a hyaluronic acid-containing ?ller injection for nasal dorsum augmentation twelve hours prior to presentation. Visual acuity of the right eye was counting finger. A right relative afferent pupillary defect was demonstrated with ophthalmoplegia. Humphrey visual field test disclosed a right inferior altitudinal field defect with impairment of colour vision. Computed tomography of the orbit revealed mild enlargement of the right medial and inferior recti muscles. Our patient showed a tremendous improvement of vision after a subcutaneous hyaluronidase injection with complete visual recovery within 2 weeks. 相似文献
5.
Descriptive assessment on diabetic retinopathy screening in an awareness programme in Malaysia 下载免费PDF全文
Nor Fariza Ngah Nor Asiah Muham Zalifa Zakiah Asnir Roslin Azni Abdul Aziz Zaidah Mhad Kassim Siti Aishah Sahar Nor Azita Ahmad Tarmidzi Chan Li Yen Rosmawati Uthman Narjis Satar Noor Zahirah Husain Azian Adnan John Mathen Kayalakakathu Bariyah Kadas Noor Suriani Moham Shaiful Azlan Kassim 《国际眼科》2020,13(11):1808-1813
6.
Rieko?Sakai Akira?MaedaEmail author Thuy-Vy?Choi Pei-Chi?Lo Patmika?Jiaravuthisan Afifah?Mod?Shabri Han-Tang?Wang Rei?Matsuura Tasuku?Kodama Hiroshi?Eguchi Hiroomi?Okuyama Shuji?Miyagawa 《Surgery today》2018,48(1):119-126
Purpose
Various strategies, such as the generation of alpha-1,3-galactosyltransferase knocked-out pigs and CD55 transgenic pigs, have been investigated to inhibit pig to human xenogeneic rejection. Our aim is to develop strategies to overcome the hurdle of not only hyper acute rejection, but also that of cellular xenogeneic rejection (CXR). Although macrophages have been well known to play a critical role in CXR, monocyte/macrophage-mediated xenogeneic rejection has not been well studied. In this study, we evaluated the effect of CD200 in xenogeneic rejection by macrophages.Methods
Naïve swine endothelial cells (SEC) and SEC/CD200 were co-cultured with M0 macrophages and the cytotoxicity was measured by a WST-8 assay. The phagocytosis of SEC and SEC/CD200 by macrophages was analyzed by flow cytometry.Results
While CD200 failed to suppress a significant amount of cytotoxicity against SEC by monocytes, M0 macrophage-mediated cytotoxicity was significantly suppressed by human CD200. The phagocytosis by M0 macrophages was also tested. The phagocytosis assay revealed that human CD200 suppresses M0 macrophage-mediated phagocytosis.Conclusions
Our findings indicate that human CD200 suppresses the xenogeneic rejection by CD200R+ macrophages and that the generation of hCD200 transgenic pigs for use in xenografts is very attractive for preventing the macrophage-mediated rejection.7.
8.
Sherina Mohd-Sidik Mehrnoosh Akhtari-Zavare Ummavathy Periasamy Lekhraj Rampal Siti Irma Fadhilah Rozi Mahmud 《Patient education and counseling》2018,101(5):862-871
Objectives
The aim of this study was to implement and evaluate the outcomes of chemotherapy counselling based on the “Managing Patients on Chemotherapy” module on self-esteem and psychological affect (anxiety, depression) of cancer patients by pharmacists in ten selected government hospitals in Peninsular Malaysia.Methods
A randomized control trial was conducted among 2120 cancer patients from April 2016 to January 2017 in ten selected government hospitals in Peninsular Malaysia. Cancer patients were randomly assigned to intervention and control groups. The intervention group received chemotherapy counselling by pharmacists based on the “Managing Patients on Chemotherapy” module. The outcomes were assessed at baseline, 1st, 2nd and 3rd follow-ups after counselling. In the course of data analysis; independent sample t-test, chi-square and two-way repeated measures ANOVA were conducted.Results
Mean scores of self-esteem in the intervention group had significant difference in comparison with those of the control group in the 1st, 2nd and 3rd follow-ups after counselling (P?<?0.0001). Also, among those with depression and anxiety at baseline, there was reduction in depression and anxiety scores after the 1st, 2nd and 3rd follow-ups after counselling (p?<?0.05).Conclusion
Repetitive counselling by pharmacists based on the “Managing Patients on Chemotherapy” module had positive effect on improving self-esteem and psychological affect of cancer patients undergoing chemotherapy in Peninsular Malaysia.Practice implications
This module can be used for all Malaysian cancer patients undergoing chemotherapy to improving self-esteem and psychological affect. 相似文献9.
10.
Marzieh JABBARZARE Voon Kin CHIN Herni TALIB Mun Fei YAM Siti Khadijah ADAM Haniza HASSAN Roslaini ABDUL MAJID Che Norma MAT TAIB Mohamad Aris MOHD MOKLAS Mohamad TAUFIK HIDAYAT Hasidah MOHD SIDEK Rusliza BASIR 《Iranian Journal of Parasitology》2015,10(3):389-401
Background: Interleukin 18 (IL-18) exerts pleiotropic roles in many inflammatory-related diseases including parasitic infection. Previous studies have demonstrated the promising therapeutic potential of modulating IL-18 bioactivity in various pathological conditions. However, its involvement during malaria infection has yet to be established. In this study, we demonstrated the effect of modulating IL-18 on the histopathological conditions of malaria infected mice.
Methods:
Plasmodium berghei ANKA infection in male ICR mice was used as a model for malaria infection. Modulation of IL-18 release was carried out by treatment of malarial mice with recombinant mouse IL-18 (rmIL-18) and recombinant mouse IL-18 Fc chimera (rmIL-18Fc) intravenously. Histopathological study and analysis were performed on major organs including brain, liver, spleen, lungs and kidney.
Results: Treatment with rmIL-18Fc resulted in significant improvements on the histopathological conditions of the organs in malaria-infected mice.
Conclusion: IL-18 is an important mediator of malaria pathogenesis and targeting IL-18 could prove beneficial in malaria-infected host.Key Words: Malaria, Interleukin-18, Plasmodium berghei, Histopathology 相似文献