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1.
Post-induction hypotension is common and associated with postoperative complications. We hypothesised that pneumatic leg compression reduces post-induction hypotension in elderly patients undergoing robot-assisted laparoscopic prostatectomy. In this double-blind randomised study, patients were allocated randomly to the pneumatic leg compression group (n = 50) or control (n = 50). In the intervention group, pneumatic leg compression was initiated before induction of anaesthesia. In the control group, pneumatic leg compression was initiated 20 min after anaesthesia induction. The primary outcome was the incidence of post-induction hypotension in these groups. Post-induction hypotension was defined as systolic blood pressure < 90 mmHg during the first 20 min after induction. Haemodynamic variables and area under the curve of post-induction systolic blood pressure over time were assessed. Complications associated with pneumatic leg compression were recorded, including: peripheral neuropathy; compartment syndrome; extensive bullae beneath the leg sleeves; and pulmonary thromboembolism. The incidence of post-induction hypotension decreased in the pneumatic leg compression group compared with that in the control group; 5 (10%) vs. 29 (58%), respectively, p < 0.001. In the pneumatic leg compression group, the lowest systolic, diastolic and mean blood pressures 20 min after induction of anaesthesia were significantly greater than the control group. Pneumatic leg compression resulted in an increased area under the curve of systolic blood pressure in the first 20 min after induction, p = 0.001. There were no pneumatic leg compression-related complications. Pneumatic leg compression reduced post-induction hypotension in elderly patients undergoing robot-assisted laparoscopic prostatectomy, suggesting that it is an effective and safe intervention to prevent post-induction hypotension among elderly patients undergoing general anaesthesia. 相似文献
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Biniam Kidane MD MSc Ian J. Gerard MD PhD Jonathan Spicer MD PhD Julian O. Kim MD MSc BEng Pierre O. Fiset MD PhD Paul Wawryko MD Matthew J. Cecchini MD PhD Richard Inculet MD Bassam Abdulkarim MD PhD Dalilah Fortin MD Mehdi Qiabi MD MSc Gefei Qing MD Stephanie Enns BSc Bashir Bashir MBBS James Tankel MD Elliot Wakeam MD Andrew Warner MSc Neil Kopek MD Brian P. Yaremko MD MSc PEng George B. Rodrigues MD PhD Joanna M. Laba MD Melody Qu MD MPH Richard A. Malthaner MD MSc David A. Palma MD PhD 《Cancer》2023,129(18):2798-2807
Background
During coronavirus disease 2019 (COVID-19)–related operating room closures, some multidisciplinary thoracic oncology teams adopted a paradigm of stereotactic ablative radiotherapy (SABR) as a bridge to surgery, an approach called SABR-BRIDGE. This study presents the preliminary surgical and pathological results.Methods
Eligible participants from four institutions (three in Canada and one in the United States) had early-stage presumed or biopsy-proven lung malignancy that would normally be surgically resected. SABR was delivered using standard institutional guidelines, with surgery >3 months following SABR with standardized pathologic assessment. Pathological complete response (pCR) was defined as absence of viable cancer. Major pathologic response (MPR) was defined as ≤10% viable tissue.Results
Seventy-two patients underwent SABR. Most common SABR regimens were 34 Gy/1 (29%, n = 21), 48 Gy/3–4 (26%, n = 19), and 50/55 Gy/5 (22%, n = 16). SABR was well-tolerated, with one grade 5 toxicity (death 10 days after SABR with COVID-19) and five grade 2–3 toxicities. Following SABR, 26 patients underwent resection thus far (13 pending surgery). Median time-to-surgery was 4.5 months post-SABR (range, 2–17.5 months). Surgery was reported as being more difficult because of SABR in 38% (n = 10) of cases. Thirteen patients (50%) had pCR and 19 (73%) had MPR. Rates of pCR trended higher in patients operated on at earlier time points (75% if within 3 months, 50% if 3–6 months, and 33% if ≥6 months; p = .069). In the exploratory best-case scenario analysis, pCR rate does not exceed 82%.Conclusions
The SABR-BRIDGE approach allowed for delivery of treatment during a period of operating room closure and was well-tolerated. Even in the best-case scenario, pCR rate does not exceed 82%. 相似文献4.
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Jon C. Tilburt MD David Zahrieh PhD Joel E. Pacyna MA Daniel G. Petereit MD Judith S. Kaur MD Bruce D. Rapkin PhD Robert L. Grubb III MD George J. Chang MD Michael J. Morris MD Evan Z. Kovac MD Kara N. Babaian MD Jeff A. Sloan PhD Ethan M. Basch MD Elizabeth S. Peil MHA Amylou C. Dueck PhD Paul J. Novotny MS Electra D. Paskett PhD Jan C. Buckner MD Daniel D. Joyce MD Victor M. Montori MD Dominick L. Frosch PhD Robert J. Volk PhD Simon P. Kim MD 《Cancer》2022,128(6):1242-1251
7.
Young-Chan Kim Sungmi Choi Kyoung-Hee Sohn Ji-Young Bang Yuldam Kim Jae-Woo Jung Hye-Young Kim Jaehyun Park Kangjin Kim Min-Gyu Kang Min-Suk Yang Sujeong Kim Sae-Hoon Kim Jeong-Hee Choi Hye Jung Park Sang Min Lee Sang Heon Kim Jung-Won Park Jong Myung Lee Sang-Heon Cho Sungho Won Hana Yi Hye-Ryun Kang 《Allergy》2022,77(1):317-320
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Lee Yun Hee Kim Yeon Sil Choi Kyu Hye Sung SooYoon Jeong Bae Kwon Ha In Bong Kang Ki Mun Lee Jayoung Lee Jong Hoon Kim Sung Hwan 《International journal of clinical oncology / Japan Society of Clinical Oncology》2022,27(1):202-212
International Journal of Clinical Oncology - We evaluated whether there is a difference in the local recurrence and survival after pelvic external radiotherapy (ERT) with and without boost vaginal... 相似文献
10.
Rhee Tae-Min Kim Hyung-Kwan Choi You-Jung Lee Hyun-Jung Hwang In-Chang Yoon Yeonyee E. Kim Hack-Lyoung Park Jun-Bean Lee Seung-Pyo Kim Yong-Jin Cho Goo-Yeong 《The international journal of cardiovascular imaging》2022,38(9):1939-1950
The International Journal of Cardiovascular Imaging - The new version of EchoPAC platform was recently developed by General Electronics (GE) to provide ‘vendor-independent’... 相似文献